Volume 4, Issue 1 (2024) – 7 articles
Cover Picture: This article examines the potential association between liver fibrosis and the risk of gynecological cancers, focusing on individuals with nonalcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated fatty liver disease (MAFLD). The study by Crudele et al. highlights a link between surrogate markers of liver fibrosis and gynecological cancers in dysmetabolic women. Notably, NAFLD/MAFLD adults exhibit a higher susceptibility to gynecological cancers, with NAFLD prevalence reaching 81.3%, especially in breast and gynecological cancers. The conclusions emphasize the need for further studies to understand the clinical and molecular aspects of the relationship between metabolic dysfunction, hepatic fibrosis, and gynecological cancers. Confirming this link through adequately sized studies with both liver histology and non-invasive techniques is crucial for clinical implications. The article suggests that medical care for these individuals should extend beyond liver-related issues, incorporating interdisciplinary approaches for screening, diagnosis, and management of gynecological cancers. The intricate mechanisms linking liver fibrosis to gynecological cancer risk remain incompletely understood and warrant additional investigation.
view this paper 
