Special Issue

Topic: Liver Fibrosis in Metabolic Dysfunction: Cellular and Molecular Mechanisms, Innovative Diagnostics, and Emerging Therapeutic Approaches

A Special Issue of Metabolism and Target Organ Damage

ISSN 2769-6375 (Online)

Submission deadline: 30 Jun 2025

Guest Editor

Prof. Sonia Michael Najjar
Department of Biomedical Sciences and the Diabetes Institute, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH, USA.

Special Issue Introduction

Liver fibrosis is the result of an excessive wound-healing process triggered by chronically acting physical, biochemical, and cellular stimuli in the liver. Initially, liver fibrosis develops silently, but as it progresses, mechanobiological forces increasingly prevail and significant architectural changes lead to liver cirrhosis and may culminate in complications such as clinically significant portal hypertension, liver failure, and hepatocellular carcinoma.

Given the increasing impact of liver fibrosis on clinical workload and health care costs worldwide, this Special Issue focuses specifically on liver fibrosis resulting from metabolic dysfunction.

We invite manuscripts that address any aspects of this condition, including epidemiology, pathogenesis, diagnosis, and management. We are particularly interested in histological and non-invasive diagnostic strategies, such as algorithms, biomarkers, imaging techniques, and the emerging role of artificial intelligence in these efforts. Additionally, we welcome submissions on molecular and cellular mechanisms, clinical observations, experimental evidence, and outcomes research related to liver fibrosis and its impact on cardiovascular-renal-metabolic health, all-cause mortality, and the development of hepatic and extrahepatic cancers. We also encourage submissions on all aspects of detection and treatment of liver fibrosis in metabolic dysfunction-associated steatotic liver disease.

Submission Deadline

30 Jun 2025

Submission Information

For Author Instructions, please refer to https://www.oaepublish.com/mtod/author_instructions
For Online Submission, please login at https://www.oaecenter.com/login?JournalId=mtod&IssueId=mtod2506302034
Submission Deadline: 30 Jun 2025
Contacts: Lily Luo, Assistant Editor, lily@oae-publish.com

Published Articles

Insulin increases type I collagen synthesis in hepatic stellate cells via α5β1 integrin
Open Access Original Article 10 Dec 2024
Views: Downloads:
Download PDF
Mouse models of primary sclerosing cholangitis: we just can’t get enough
Open Access Commentary 4 Dec 2024
Views: Downloads:
Download PDF
Liver fibrosis as a barometer of systemic health by gauging the risk of extrahepatic disease
Open Access Review 14 Nov 2024
Views: Downloads:
Download PDF
Copper and liver fibrosis in MASLD: the two-edged sword of copper deficiency and toxicity
Open Access Review 20 Sep 2024
Views: Downloads:
Download PDF
Noninvasive testing in the diagnosis of metabolic dysfunction-associated steatohepatitis
Open Access Review 21 Aug 2024
Views: Downloads:
Download PDF
Metabolism and Target Organ Damage
ISSN 2769-6375 (Online)
Follow Us

Portico

All published articles are preserved here permanently:

https://www.portico.org/publishers/oae/

Portico

All published articles are preserved here permanently:

https://www.portico.org/publishers/oae/