Special Issue

Topic: Organ Dysfunction in Metabolic-Associated Fatty Liver Disease: Effect of Cofactors

A Special Issue of Metabolism and Target Organ Damage

ISSN 2769-6375 (Online)

Submission deadline: 31 Dec 2023

Guest Editor(s)

Kusum K. Kharbanda, PhD
Department of Internal Medicine, University Nebraska Medical Center, Veteran Affairs Medical Center, Omaha, NE, USA.
Ashwani K. Singal, MD

Sanford School of Medicine, University of South Dakota, Vermillion, SD, USA.

Amedeo Lonardo, MD

Department of Internal Medicine, Ospedale Civile di Baggiovara, Modena, Italy.

Natalia A. Osna, MD, PhD

Department of Internal Medicine, University of Nebraska Medical Center, Veteran Affairs Medical Center, Omaha, NE, USA.

Special Issue Introduction

Nonalcoholic fatty liver disease (NAFLD), now tendentially renamed MAFLD (metabolic-associated fatty liver disease), is a systemic metabolic disorder that encompasses a clinico-pathological spectrum ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma.

NAFLD and NASH are pathogenically associated with gut dysbiosis, sarcopenia and expanded, dysfunctional adipose tissue. Clinically, extra-hepatic manifestations, notably either the full-blown metabolic syndrome or its individual components and cardio-nephro-vascular complications, are major features of MAFLD and dictate the disease course.

This thematic Special Issue highlights metabolic syndrome co-factors, including but not limited to alcohol, diet, immune surveillance, infection, genetics, epifactors and sedentary behavior, which affect liver disease progression and also induce dysfunction in other target organs and organ systems such as gastrointestinal, cardiovascular, adipose, muscle, kidneys and pancreas.

Original research, review articles, and short communications on the role of co-factors exacerbating organ dysfunction in MAFLD are welcome to this topical Special Issue.

Submission Deadline

31 Dec 2023

Submission Information

For Author Instructions, please refer to https://oaepublish.com/mtod/author_instructions
For Online Submission, please login at https://oaemesas.com/login?JournalId=mtod&SpecialIssueId=mtod220601
Submission Deadline: 31 Dec 2023
Contacts: Doreen Deng, Managing Editor, editorialoffice@mtodjournal.net
                  Jimmy Yin, Science Editor, jimmy@mtodjournal.net

Published Articles

Open Access Commentary

PNPLA3 rs738409 polymorphism and kidney dysfunction: an association beyond nonalcoholic fatty liver disease?

Metab Target Organ Damage 2023;3:18.
DOI: 10.20517/mtod.2023.24
Available online: 18 Oct 2023
Open Access Perspective

Effect of cofactors on NAFLD/NASH and MAFLD - a paradigm illustrating the pathomechanics of organ dysfunction

Metab Target Organ Damage 2022;2:12.
DOI: 10.20517/mtod.2022.14
Available online: 21 Aug 2022
Metabolism and Target Organ Damage
ISSN 2769-6375 (Online)

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All published articles are preserved here permanently:

https://www.portico.org/publishers/oae/