Special Issue

Topic: DNA Repair & Metabolism and Cancer Drug Resistance

A Special Issue of Cancer Drug Resistance

ISSN 2578-532X (Online)

Submission deadline: 15 Jun 2023

Guest Editor(s)

Dr. Robert W. Sobol
Mitchell Cancer Institute, College of Medicine, University of South Alabama, Mobile, AL, USA.
Dr. Natalie R. Gassman
Mitchell Cancer Institute, College of Medicine, University of South Alabama, Mobile, AL, USA.
Dr. Marie E. Migaud
Mitchell Cancer Institute, College of Medicine, University of South Alabama, Mobile, AL, USA.

Special Issue Introduction

Repair of DNA damage and the ensuing DNA damage response is a highly complex process that involves chromatin re-organization, the initiation of signaling networks, and cell cycle checkpoints. It mainly relies on the PARP- and SIRT-family of enzymes, across the spectrum of DNA repair and response pathways, and involves modification of DNA methylation profiles and methylation of chromatin-bound proteins. The orchestration of these protein-driven events relies on small molecule modifiers such as ATP (protein phosphorylation), NAD+ (protein ADP-ribosylation and deacylation), acyl-coA (protein acylation), and SAM (nucleic acid and histone methylation). Further, there are additional processes that engage and regulate macromolecules such as ubiquitylation, NEDDylation and SUMOylation. Crucially, each small molecule modifier is a cofactor that is consumed in such cellular processes and is directly involved in and affected by central cellular metabolic processes. Importantly, metabolism is an adaptive process often observed to be dramatically different in cancer, which is considered to be a hallmark of cancer and of cancer drug resistance. The abundance and availability of these cofactors might greatly affect DNA repair and the cellular response to cancer drug treatment. Through metabolic adaptation, be it causative or consecutive to the emergence of drug resistance, the axis between DNA repair, metabolism, and cancer drug resistance offers a scope for greater understanding of this synergy and covers the research that this Special Issue on cancer drug resistance seeks to encompass. Overall, we are looking for submissions that highlight the interconnectivity and interdependence of DNA repair and metabolism in cancer drug resistance.

Submission Deadline

15 Jun 2023

Submission Information

For Author Instructions, please refer to https://www.oaepublish.com/cdr/author_instructions
For Online Submission, please login at https://oaemesas.com/login?JournalId=cdr&SpecialIssueId=653
Submission Deadline: 15 Jun 2023
Contacts: Susan Song, Assistant Editor, Susan@cdrjournal.com

Published Articles

Base excision repair accessory factors in senescence avoidance and resistance to treatments

Open Access Review DOI: 10.20517/cdr.2022.36 21 Jun 2022
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RIP140 regulates POLK gene expression and the response to alkylating drugs in colon cancer cells

Open Access Original Article DOI: 10.20517/cdr.2021.133 6 May 2022
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DNA damage and metabolic mechanisms of cancer drug resistance

Open Access Review DOI: 10.20517/cdr.2021.148 4 May 2022
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Targeting of PI3K/AKT signaling and DNA damage response in acute myeloid leukemia: a novel therapeutic strategy to boost chemotherapy response and overcome resistance

Open Access Mini Review DOI: 10.20517/cdr.2021.76 9 Nov 2021
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Cancer Drug Resistance
ISSN 2578-532X (Online)
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