REFERENCES
1. Oh, J.; Kim, S.; Yim, Y.; et al.; GBD 2023 Global Chronic Respiratory Disease and Covid Collaborators. Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990-2023: a Global Burden of Disease study. Nat. Med. 2026, 32, 197-223.
2. GBD 2019 Chronic Respiratory Diseases Collaborators. Global burden of chronic respiratory diseases and risk factors, 1990-2019: an update from the Global Burden of Disease Study 2019. EClinicalMedicine 2023, 59, 101936.
3. Cao, Z.; Tong, X.; He, L.; et al. Burden of chronic obstructive pulmonary disease and its attributable risk factors in 204 countries and territories, 1990-2021: results from the Global Burden of Disease Study 2021. BMJ. Public. Health. 2026, 4, e002489.
4. Alves Pegoraro, J.; Guerder, A.; Similowski, T.; Salamitou, P.; Gonzalez-Bermejo, J.; Birmelé, E. Detection of COPD exacerbations with continuous monitoring of breathing rate and inspiratory amplitude under oxygen therapy. BMC. Med. Inform. Decis. Mak. 2025, 25, 101.
5. Yentes, J. M.; Fallahtafti, F.; Denton, W.; Rennard, S. I. COPD patients have a restricted breathing pattern that persists with increased metabolic demands. COPD 2020, 17, 245-52.
6. Zulkifli, N. A.; Jeong, W.; Kim, M.; et al. 3D-printed magnetic-based air pressure sensor for continuous respiration monitoring and breathing rehabilitation. Soft. Sci. 2024, 4, 20.
7. Xu, M.; Liu, F.; Chen, L.; et al. Zwitterionic poly(ionic liquid) hydrogel electrolytes with high-speed ion conduction channels for dendrite-free, long-enduring zinc-ion batteries and flexible electronics. Energy. Storage. Mater. 2025, 80, 104373.
8. Tipton, M. J.; Harper, A.; Paton, J. F. R.; Costello, J. T. The human ventilatory response to stress: rate or depth? J. Physiol. 2017, 595, 5729-52.
9. Paredi, P.; Kharitonov, S. A.; Barnes, P. J. Correlation of exhaled breath temperature with bronchial blood flow in asthma. Respir. Res. 2005, 6, 15.
10. Annesi-Maesano, I.; Dinh-Xuan, A. T. Is exhaled nitric oxide a marker of air pollution effect? Eur. Respir. J. 2016, 47, 1304-6.
11. Heng, W.; Yin, S.; Chen, Y.; Gao, W. Exhaled breath analysis: from laboratory test to wearable sensing. IEEE. Rev. Biomed. Eng. 2025, 18, 50-73.
12. Pan, J.; Li, Y.; Tian, T.; Tang, Z.; Lian, Z.; Ma, N. Highly sensitive humidity sensor based on NaCl-BiFeO3 for noncontact sensing. ACS. Appl. Electron. Mater. 2025, 7, 1842-51.
13. Al-Halhouli, A.; Albagdady, A.; Rabadi, A.; Hamdan, M.; Abu-Khalaf, J.; Abu-Abeeleh, M. Screen-printed wearable sensors for continuous respiratory rate monitoring: fabrication, clinical evaluation, and point-of-care potential. Mater. Adv. 2024, 5, 9586-95.
14. Dong, H.; Li, X.; Liu, Y.; et al. Wearable, breathable, and wireless gas sensor enables highly selective exhaled ammonia detection and real-time noninvasive illness diagnosis. ACS. Sens. 2025, 10, 3964-75.
15. Shin, J.; Jeong, B.; Kim, J.; et al. Sensitive wearable temperature sensor with seamless monolithic integration. Adv. Mater. 2020, 32, e1905527.
16. Ye, L.; Wu, F.; Xu, R.; et al. Face mask integrated with flexible and wearable manganite oxide respiration sensor. Nano. Energy. 2023, 112, 108460.
17. Li, Y.; Wang, R.; Wang, G. E.; et al. Mutually noninterfering flexible pressure-temperature dual-modal sensors based on conductive metal-organic framework for electronic skin. ACS. Nano. 2022, 16, 473-84.
18. Shi, W.; Yang, X.; Lei, L.; et al. Human respiration monitoring using humidity and temperature dual-modal sensors for temperature-insensitive humidity sensing and synchronous temperature sensing. Sens. Actuators. A. Phys. 2025, 395, 117008.
19. Ma, B.; Huang, K.; Chen, G.; et al. A dual-mode wearable sensor with coupled ion and pressure sensing. Soft. Sci. 2024, 4, 8.
21. Hua, Q.; Sun, J.; Liu, H.; et al. Skin-inspired highly stretchable and conformable matrix networks for multifunctional sensing. Nat. Commun. 2018, 9, 244.
22. Jia, Q.; Ye, W.; Zhang, C.; et al. Wearable multimodal sensing system for synchronously health-environmental monitoring via hybrid neuroevolutionary signal decoupling. Nano. Lett. 2025, 25, 9726-33.
23. Fang, Y.; Ouyang, H.; Cheng, Y.; et al. Ultrasensitive multi-degree-of-freedom piezoionic sensor via synergistic hydrogel-ion interactions. Nat. Commun. 2025, 17, 893.
24. Wu, T.; Li, Y. T.; Zhao, L.; et al. Recent progress on flexible multimodal sensors: decoupling strategies, fabrication and applications. Adv. Mater. 2026, 38, e21375.
25. Zhou, Z.; Wu, H.; Fu, J.; et al. Fully integrated passive wireless sensor with mechanical-electrical double-gradient for multifunctional healthcare monitoring. Nano. Lett. 2024, 24, 14781-9.
26. Zhou, Z.; Jin, Y.; Fu, J.; et al. Smart wireless flexible sensing system for unconstrained monitoring of ballistocardiogram and respiration. npj. Flex. Electron. 2025, 9, 388.
27. Mariello, M.; Rosenthal, J. D.; Cecchetti, F.; et al. Wireless, battery-free, and real-time monitoring of water permeation across thin-film encapsulation. Nat. Commun. 2024, 15, 7443.
28. Wang, G. E.; Xu, G.; Zhang, N. N.; Yao, M. S.; Wang, M. S.; Guo, G. C. From lead iodide to a radical form lead-iodide superlattice: high conductance gain and broader band for photoconductive response. Angew. Chem. Int. Ed. Engl. 2019, 58, 2692-5.
29. Chen, T.; Dou, J. H.; Yang, L.; et al. Continuous electrical conductivity variation in M3(Hexaiminotriphenylene)2 (M = Co, Ni, Cu) MOF alloys. J. Am. Chem. Soc. 2020, 142, 12367-73.
30. Kirchgessner, M.; Sreenath, K.; Gopidas, K. R. Understanding reactivity patterns of the dialkylaniline radical cation. J. Org. Chem. 2006, 71, 9849-52.
31. Zhang, P.; He, P.; Zhao, Y.; et al. Oxidating fresh porous graphene networks toward ultra‐large graphene oxide with electrical conductivity. Adv. Funct. Mater. 2022, 32, 2202697.
32. Pyo, S.; Lee, J.; Bae, K.; Sim, S.; Kim, J. Recent progress in flexible tactile sensors for human-interactive systems: from sensors to advanced applications. Adv. Mater. 2021, 33, e2005902.
33. Xu, B.; Yang, M.; Cheng, W.; et al. Precision aerosol-jet micropatterning of liquid metal for high-performance flexible strain sensors. Nat. Commun. 2025, 16, 7920.
34. Geng, D.; Chen, S.; Chen, R.; et al. Tunable wide range and high sensitivity flexible pressure sensors with ordered multilevel microstructures. Adv. Mater. Technol. 2022, 7, 2101031.
35. Wang, S.; Deng, W.; Yang, T.; et al. Bioinspired MXene‐based piezoresistive sensor with two‐stage enhancement for motion capture. Adv. Funct. Mater. 2023, 33, 2214503.
36. Wang, Y.; Zhang, Y.; Zhang, P.; Zhang, W. High intrinsic carrier mobility and photon absorption in the perovskite CH3NH3PbI3. Phys. Chem. Chem. Phys. 2015, 17, 11516-20.
37. Yin, Y.; Wang, Y.; Li, H.; et al. A flexible dual parameter sensor with hierarchical porous structure for fully decoupled pressure–temperature sensing. Chem. Eng. J. 2022, 430, 133158.
38. Li, M.; Chen, J.; Zhong, W.; et al. Large-area, wearable, self-powered pressure-temperature sensor based on 3D thermoelectric spacer fabric. ACS. Sens. 2020, 5, 2545-54.
39. Zhang, X.; Gong, Y.; Xie, F.; Sun, P.; Jiang, S. Dual-mode temperature-pressure MXene sensor for enhanced firefighter safety and deep learning-enhanced smart gloves. ACS. Appl. Mater. Interfaces. 2025, 17, 38280-7.
40. Wang, N.; Xia, Z.; Yang, S.; et al. Pressure-temperature dual-parameter sensors designed by wood-derived thermoelectric composites: micro-pressure high sensitivity. Compos. Part. B. Eng. 2023, 264, 110928.
41. Wang, Y.; Wu, H.; Xu, L.; Zhang, H.; Yang, Y.; Wang, Z. L. Hierarchically patterned self-powered sensors for multifunctional tactile sensing. Sci. Adv. 2020, 6, eabb9083.
42. Desisto, W. J.; Cashon, R.; Cassidy, D.; et al. Preparation and characterization of a selective nitric oxide adsorbent based on Cobalt(II) phthalocyanine tetrasulfonic acid. Ind. Eng. Chem. Res. 2008, 47, 7857-61.
43. Jo, Y. M.; Jo, Y. K.; Lee, J. H.; Jang, H. W.; Hwang, I. S.; Yoo, D. J. MOF-based chemiresistive gas sensors: toward new functionalities. Adv. Mater. 2023, 35, e2206842.
44. Xu, S.; Liu, X.; Wu, J.; Wu, J. NOx sensor constructed from conductive metal-organic framework and graphene for airway inflammation screening. ACS. Sens. 2023, 8, 2348-58.
45. Chang, Y.; Chen, M.; Fu, Z.; et al. Building porphyrin-based MOFs on MXenes for ppb-level NO sensing. J. Mater. Chem. A. 2023, 11, 6966-77.
46. Pang, Z.; Zhao, Y.; Luo, N.; Chen, D.; Chen, M. Flexible pressure and temperature dual-mode sensor based on buckling carbon nanofibers for respiration pattern recognition. Sci. Rep. 2022, 12, 17434.
47. Buist, M.; Bernard, S.; Nguyen, T. V.; Moore, G.; Anderson, J. Association between clinically abnormal observations and subsequent in-hospital mortality: a prospective study. Resuscitation 2004, 62, 137-41.
48. Flenady, T.; Dwyer, T.; Applegarth, J. Accurate respiratory rates count: so should you! Australas. Emerg. Nurs. J. 2017, 20, 45-7.
49. Borst, C.; Wieling, W.; van Brederode, J. F.; Hond, A.; de Rijk, L. G.; Dunning, A. J. Mechanisms of initial heart rate response to postural change. Am. J. Physiol. 1982, 243, H676-81.
50. Weckenmann, M. [The pulse-respiratory quotient of persons with stable and instable postural circulation while standing (author’s transl)]. Basic. Res. Cardiol. 1975, 70, 339-49.
51. von Bonin, D.; Grote, V.; Buri, C.; et al. Adaption of cardio-respiratory balance during day-rest compared to deep sleep - an indicator for quality of life? Psychiatry. Res. 2014, 219, 638-44.
52. Zhang, C.; Zong, P.; Ge, Z.; et al. MXene-based wearable thermoelectric respiration sensor. Nano. Energy. 2023, 118, 109037.
53. Chen, X.; Zhang, H.; Li, Z.; Liu, S.; Zhou, Y. Continuous monitoring of heart rate variability and respiration for the remote diagnosis of chronic obstructive pulmonary disease: prospective observational study. JMIR. Mhealth. Uhealth. 2024, 12, e56226.
54. Kesten, S.; Maleki-Yazdi, R.; Sanders, B. R.; et al. Respiratory rate during acute asthma. Chest 1990, 97, 58-62.
55. Huffaker, M. F.; Carchia, M.; Harris, B. U.; et al. Passive nocturnal physiologic monitoring enables early detection of exacerbations in children with asthma. A proof-of-concept study. Am. J. Respir. Crit. Care. Med. 2018, 198, 320-8.
56. Dweik, R. A.; Boggs, P. B.; Erzurum, S. C.; et al.; American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am. J. Respir. Crit. Care. Med. 2011, 184, 602-15.
57. Jeppegaard, M.; Veidal, S.; Sverrild, A.; Backer, V.; Porsbjerg, C. Validation of ATS clinical practice guideline cut-points for FeNO in asthma. Respir. Med. 2018, 144, 22-9.
58. Rupani, H.; Kent, B. D. Using fractional exhaled nitric oxide measurement in clinical asthma management. Chest 2022, 161, 906-17.
59. Liu, X.; Zhang, H.; Wang, Y.; et al. Fractional exhaled nitric oxide is associated with the severity of stable COPD. COPD 2020, 17, 121-7.







