fig2

Figure 2. Homocysteine-lowering effects of OCM cofactor supplements in males and females (A-C). Figures depict the simulated effects of OCM cofactors (Vitamins B6 and B12, folate, and betaine) and their combination on hepatic homocysteine under different nutritional statuses, ranging from 0.2 or 0.25 (i.e., deficient) to 2 or 4 (i.e., high intake), where 1 is the reference state. OCM: One-carbon metabolism.