fig6

Figure 6. Tissue and cell type specificity derived from the shared signals linking MASLD and CMTs. (A) Tissue enrichment for the shared genes between MASLD and CMTs, as identified by GTEx; (B) Cell type-specific enrichment for the shared genes between MASLD and CMTs, derived from CATLAS or expression of cell type-specific genes in 111 single-cell transcriptomes. MASLD: Metabolic dysfunction-associated steatotic liver disease; CMTs: cardiometabolic traits; GTEx: Genotype-Tissue Expression project; AAA: abdominal aortic aneurysm; WHRadjBMI: WHR adjusted for BMI; WHR: waist-to-hip ratio; BMI: body mass index; T2D: type 2 diabetes; VTE: venous thromboembolism; TG: triglyceride; nonHDLC: non-HDL cholesterol.