fig3

Figure 3. Mediation analysis of SBP in the association between eGDR and renal dysfunction. The total effect was partitioned into direct and indirect effects, with the latter quantifying the mediated pathway through SBP. Specifically, the indirect effect was calculated as the product of (a) the effect of eGDR on SBP and (b) the effect of SBP on renal dysfunction. The mediation proportion was expressed as (indirect effect/total effect) × 100%. The total effect (c) was defined as the sum of the direct effect (c’) and the indirect effect (a × b). SBP: Systolic blood pressure; eGDR: estimated glucose disposal rate.