REFERENCES
1. English WJ, DeMaria EJ, Hutter MM, et al. American Society for Metabolic and Bariatric Surgery 2018 estimate of and bariatric procedures performed in the United States. Surg Obes Relat Dis. 2020;16:457-63.
2. Coblijn UK, Lagarde SM, de Castro SM, Kuiken SD, van Wagensveld BA. Symptomatic marginal ulcer disease after Roux-en-Y gastric bypass: incidence, risk factors and management. Obes Surg. 2015;25:805-11.
3. Pyke O, Yang J, Cohn T, et al. Marginal ulcer continues to be a major source of morbidity over time following gastric bypass. Surg Endosc. 2019;33:3451-6.
4. Csendes A, Burgos AM, Altuve J, Bonacic S. Incidence of marginal ulcer 1 month and 1 to 2 years after gastric bypass: a prospective consecutive endoscopic evaluation of 442 patients with morbid obesity. Obes Surg. 2009;19:135-8.
5. Ying VW, Kim SH, Khan KJ, et al. Prophylactic PPI help reduce marginal ulcers after gastric bypass surgery: a systematic review and meta-analysis of cohort studies. Surg Endosc. 2015;29:1018-23.
6. Schulman AR, Chan WW, Devery A, Ryan MB, Thompson CC. Opened proton pump inhibitor capsules reduce time to healing compared with intact capsules for marginal ulceration following Roux-en-Y gastric bypass. Clin Gastroenterol Hepatol. 2017;15:494-500.e1.
7. Barola S, Magnuson T, Schweitzer M, et al. Endoscopic suturing for massively bleeding marginal ulcer 10 days post Roux-en-Y gastric bypass. Obes Surg. 2017;27:1394-6.
8. Csendes A, Torres J, Burgos AM. Late marginal ulcers after gastric bypass for morbid obesity. Clinical and endoscopic findings and response to treatment. Obes Surg. 2011;21:1319-22.
9. Clapp B, Hahn J, Dodoo C, Guerra A, de la Rosa E, Tyroch A. Evaluation of the rate of marginal ulcer formation after bariatric surgery using the MBSAQIP database. Surg Endosc. 2019;33:1890-7.
10. Wilson JA, Romagnuolo J, Byrne TK, Morgan K, Wilson FA. Predictors of endoscopic findings after Roux-en-Y gastric bypass. Am J Gastroenterol. 2006;101:2194-9.
11. Adduci AJ, Phillips CH, Harvin H. Prospective diagnosis of marginal ulceration following Roux-en-Y gastric bypass with computed tomography. Radiol Case Rep. 2015;10:1063.
12. Tarride JE, Doumouras AG, Hong D, et al. Association of Roux-en-Y gastric bypass with postoperative health care use and expenditures in Canada. JAMA Surg. 2020;155:e201985.
13. Enestvedt CK, Thompson SK, Chang EY, Jobe BA. Clinical review: healing in gastrointestinal anastomoses, part II. Microsurgery. 2006;26:137-43.
14. Ribeiro-Parenti L, Arapis K, Chosidow D, Marmuse JP. Comparison of marginal ulcer rates between antecolic and retrocolic laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2015;25:215-21.
15. Al Harakeh AB, Kallies KJ, Borgert AJ, Kothari SN. Bowel obstruction rates in antecolic/antegastric versus retrocolic/retrogastric Roux limb gastric bypass: a meta-analysis. Surg Obes Relat Dis. 2016;12:194-8.
16. Carrano FM, Di Lorenzo N. The use of indocyanine green in bariatric surgery: a systematic review. J Gastric Surg. 2020;2:41-4.
17. Barola S, Fayad L, Hill C, et al. Endoscopic management of recalcitrant marginal ulcers by covering the ulcer bed. Obes Surg. 2018;28:2252-60.
18. Chang PC, Huang CK, Tai CM, Huang IY, Hsin MC, Hung CM. Revision using totally hand-sewn gastrojejunostomy and truncal vagotomy for refractory marginal ulcer after laparoscopic Roux-en-y gastric bypass: a case series. Surg Obes Relat Dis. 2017;13:588-93.
19. Coblijn UK, Goucham AB, Lagarde SM, Kuiken SD, van Wagensveld BA. Development of ulcer disease after Roux-en-Y gastric bypass, incidence, risk factors, and patient presentation: a systematic review. Obes Surg. 2014;24:299-309.
20. Kelly JJ, Perugini RA, Wang QL, Czerniach DR, Flahive J, Cohen PA. The presence of Helicobacter pylori is not associated with long-term anastomotic complications in gastric bypass patients. Surg Endosc. 2015;29:2885-90.
21. Schäfer A, Gehwolf P, Kienzl-Wagner K, Cakar-Beck F, Wykypiel H. Linear or circular: anastomotic ulcer after gastric bypass surgery. Surg Endosc. 2022;36:3011-8.
22. Sundaresan N, Sullivan M, Hiticas BA, et al. Impacts of gastrojejunal anastomotic technique on rates of marginal ulcer formation and anastomotic bleeding following Roux-en-Y gastric bypass. Obes Surg. 2021;31:2921-6.
23. Leyba JL, Llopis SN, Isaac J, Aulestia SN, Bravo C, Obregon F. Laparoscopic gastric bypass for morbid obesity-a randomized controlled trial comparing two gastrojejunal anastomosis techniques. JSLS. 2008;12:385-8.
24. Lois AW, Frelich MJ, Goldblatt MI, Wallace JR, Gould JC. Gastrojejunostomy technique and anastomotic complications in laparoscopic gastric bypass. Surg Obes Relat Dis. 2015;11:808-13.
25. Fakas S, Elias M, Lim D, Meytes V. Comparison of gastrojejunostomy techniques and anastomotic complications: a systematic literature review. Surg Endosc. 2021;35:6489-96.
26. Frezza EE, Herbert H, Ford R, Wachtel MS. Endoscopic suture removal at gastrojejunal anastomosis after Roux-en-Y gastric bypass to prevent marginal ulceration. Surg Obes Relat Dis. 2007;3:619-22.
27. Ryou M, Mogabgab O, Lautz DB, Thompson CC. Endoscopic foreign body removal for treatment of chronic abdominal pain in patients after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2010;6:526-31.
28. Vasquez JC, Wayne Overby D, Farrell TM. Fewer gastrojejunostomy strictures and marginal ulcers with absorbable suture. Surg Endosc. 2009;23:2011-5.
29. Sacks BC, Mattar SG, Qureshi FG, et al. Incidence of marginal ulcers and the use of absorbable anastomotic sutures in laparoscopic Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2006;2:11-6.
30. Edholm D, Ottosson J, Sundbom M. Importance of pouch size in laparoscopic Roux-en-Y gastric bypass: a cohort study of 14,168 patients. Surg Endosc. 2016;30:2011-5.
31. Azagury DE, Abu Dayyeh BK, Greenwalt IT, Thompson CC. Marginal ulceration after Roux-en-Y gastric bypass surgery: characteristics, risk factors, treatment, and outcomes. Endoscopy. 2011;43:950-4.
32. Siilin H, Wanders A, Gustavsson S, Sundbom M. The proximal gastric pouch invariably contains acid-producing parietal cells in Roux-en-Y gastric bypass. Obes Surg. 2005;15:771-7.
33. Hedberg J, Hedenström H, Nilsson S, Sundbom M, Gustavsson S. Role of gastric acid in stomal ulcer after gastric bypass. Obes Surg. 2005;15:1375-8.
34. MacLean LD, Rhode BM, Nohr C, Katz S, McLean AP. Stomal ulcer after gastric bypass. J Am Coll Surg. 1997;185:1-7.
35. Chahine E, Kassir R, Dirani M, Joumaa S, Debs T, Chouillard E. Surgical management of gastrogastric fistula after Roux-en-Y gastric bypass: 10-year experience. Obes Surg. 2018;28:939-44.
36. Carrodeguas L, Szomstein S, Soto F, et al. Management of gastrogastric fistulas after divided Roux-en-Y gastric bypass surgery for morbid obesity: analysis of 1,292 consecutive patients and review of literature. Surg Obes Relat Dis. 2005;1:467-74.
37. Ribeiro-Parenti L, De Courville G, Daikha A, Arapis K, Chosidow D, Marmuse JP. Classification, surgical management and outcomes of patients with gastrogastric fistula after Roux-En-Y gastric bypass. Surg Obes Relat Dis. 2017;13:243-8.
38. Cucchi SG, Pories WJ, MacDonald KG, Morgan EJ. Gastrogastric fistulas. A complication of divided gastric bypass surgery. Ann Surg. 1995;221:387-91.
39. Kang X, Hong D, Anvari M, Tiboni M, Amin N, Gmora S. Is daily low-dose aspirin safe to take following laparoscopic Roux-en-Y gastric bypass for obesity surgery? Obes Surg. 2017;27:1261-5.
40. Gao G, Nezami N, Mathur M, Balcacer P, Israel G, Spektor M. Diagnosis of gastrogastric fistula on computed tomography: a quantitative approach. Abdom Radiol. 2018;43:1329-33.
41. Lopez Luciano MJ, Then EO, Brana CJ, Ofosu A, Gaduputi A. Spontaneous gastrojejunal fistulization after roux-en-y bypass surgery: a case report and review of literature. Cureus. 2019;11:e5035.
42. Di Palma A, Liu B, Maeda A, Anvari M, Jackson T, Okrainec A. Marginal ulceration following Roux-en-Y gastric bypass: risk factors for ulcer development, recurrence and need for revisional surgery. Surg Endosc. 2021;35:2347-53.
43. Süsstrunk J, Wartmann L, Mattiello D, Köstler T, Zingg U. Incidence and prognostic factors for the development of symptomatic and asymptomatic marginal ulcers after Roux-en-Y gastric bypass procedures. Obes Surg. 2021;31:3005-14.
44. Dittrich L, Schwenninger MV, Dittrich K, Pratschke J, Aigner F, Raakow J. Marginal ulcers after laparoscopic Roux-en-Y gastric bypass: analysis of the amount of daily and lifetime smoking on postoperative risk. Surg Obes Relat Dis. 2020;16:389-96.
45. Altieri MS, Pryor A, Yang J, et al. The natural history of perforated marginal ulcers after gastric bypass surgery. Surg Endosc. 2018;32:1215-22.
46. Spaniolas K, Yang J, Crowley S, et al. Association of long-term anastomotic ulceration after Roux-en-Y gastric bypass with tobacco smoking. JAMA Surg. 2018;153:862-4.
47. King WC, White GE, Belle SH, et al. Changes in smoking behavior before and after gastric bypass: a 7-year study. Ann Surg. 2022;275:131-9.
48. Chow A, Neville A, Kolozsvari N. Smoking in bariatric surgery: a systematic review. Surg Endosc. 2021;35:3047-66.
50. Tetrault JM, Crothers K, Moore BA, Mehra R, Concato J, Fiellin DA. Effects of marijuana smoking on pulmonary function and respiratory complications: a systematic review. Arch Intern Med. 2007;167:221-8.
51. Jung F, Lee Y, Manzoor S, Hong D, Doumouras AG. Effects of perioperative cannabis use on bariatric surgical outcomes: a systematic review. Obes Surg. 2021;31:299-306.
52. Gunaydin C, Bilge SS. Effects of nonsteroidal anti-inflammatory drugs at the molecular level. Eurasian J Med. 2018;50:116-21.
53. Rodrigo DC, Jill S, Daniel M, Kimberly C, Maher EC. Which factors correlate with marginal ulcer after surgery for obesity? Obes Surg. 2020;30:4821-7.
54. Hariri K, Hechenbleikner E, Dong M, Kini SU, Fernandez-Ranvier G, Herron DM. Ketorolac use shortens hospital length of stay after bariatric surgery: a single-center 5-year experience. Obes Surg. 2019;29:2360-6.
55. Simon LS, Weaver AL, Graham DY, et al. Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial. JAMA. 1999;282:1921-8.
56. Emery P, Zeidler H, Kvien TK, et al. Celecoxib versus diclofenac in long-term management of rheumatoid arthritis: randomised double-blind comparison. Lancet. 1999;354:2106-11.
57. Silverstein FE, Faich G, Goldstein JL, et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: a randomized controlled trial. celecoxib long-term arthritis safety study. JAMA. 2000;284:1247-55.
58. Jüni P, Rutjes AW, Dieppe PA. Are selective COX 2 inhibitors superior to traditional non steroidal anti-inflammatory drugs? BMJ. 2002;324:1287-8.
60. Wang YK, Kuo FC, Liu CJ, et al. Diagnosis of Helicobacter pylori infection: current options and developments. World J Gastroenterol. 2015;21:11221-35.
62. Mocanu V, Dang JT, Switzer N, et al. The effect of helicobacter pylori on postoperative outcomes in patients undergoing bariatric surgery: a systematic review and meta-analysis. Obes Surg. 2018;28:567-73.
63. Schulman AR, Abougergi MS, Thompson CC. H. Pylori as a predictor of marginal ulceration: A nationwide analysis. Obesity. 2017;25:522-6.
64. Rawlins L, Rawlins MP, Brown CC, Schumacher DL. Effect of helicobacter pylori on marginal ulcer and stomal stenosis after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2013;9:760-4.
65. Sverdén E, Mattsson F, Sondén A, et al. Risk factors for marginal ulcer after gastric bypass surgery for obesity: a population-based cohort study. Ann Surg. 2016;263:733-7.
66. Bhayani NH, Oyetunji TA, Chang DC, Cornwell EE 3rd, Ortega G, Fullum TM. Predictors of marginal ulcers after laparoscopic Roux-en-Y gastric bypass. J Surg Res. 2012;177:224-7.
67. Kaplan JA, Schecter SC, Rogers SJ, Lin MYC, Posselt AM, Carter JT. Expanded indications for bariatric surgery: should patients on chronic steroids be offered bariatric procedures? Surg Obes Relat Dis. 2017;13:35-40.
68. Boerlage TCC, Wolvers PJD, Bruin SC, et al. Upper endoscopy after Roux-en-Y gastric bypass: diagnostic yield and factors associated with relevant findings. Surg Obes Relat Dis. 2020;16:868-76.
69. Sundaresan N, Hiticas BA, Sullivan M, et al. Gastrojejunal anastomotic stricture following Roux-en-Y gastric bypass: an analysis of anastomotic technique at a single institution. Obes Surg. 2021;31:4947-52.
70. Skidmore AP. Use of lumen-apposing metal stents (LAMS) in the management of gastro jejunostomy stricture following Roux-en-Y gastric bypass for obesity: a prospective series. BMC Surg. 2021;21:314.
71. Sidani S, Akkary E, Bell R. Catastrophic bleeding from a marginal ulcer after gastric bypass. JSLS. 2013;17:148-51.
72. Vedantam S, Roberts J. Endoscopic stents in the management of bariatric complications: our algorithm and outcomes. Obes Surg. 2020;30:1150-8.
73. Crawford CB, Schuh LM, Inman MM. Revision gastrojejunostomy versus suturing with and without omental patch for perforated marginal ulcer treatment after Roux-en-Y gastric bypass. J Gastrointest Surg. 2023;27:1-6.
74. Shin JM, Sachs G. Pharmacology of proton pump inhibitors. Curr Gastroenterol Rep. 2008;10:528-34.
75. Smith CD, Herkes SB, Behrns KE, Fairbanks VF, Kelly KA, Sarr MG. Gastric acid secretion and vitamin B12 absorption after vertical Roux-en-Y gastric bypass for morbid obesity. Ann Surg. 1993;218:91-6.
76. Moon RC, Teixeira AF, Goldbach M, Jawad MA. Management and treatment outcomes of marginal ulcers after Roux-en-Y gastric bypass at a single high volume bariatric center. Surg Obes Relat Dis. 2014;10:229-34.
77. Bardal SK, Waechter JE, Martin DS. Gastroenterology. Applied Pharmacology. Elsevier; 2011. pp. 177-92.
78. Coblijn UK, Lagarde SM, de Castro SM, Kuiken SD, van Tets WF, van Wagensveld BA. The influence of prophylactic proton pump inhibitor treatment on the development of symptomatic marginal ulceration in Roux-en-Y gastric bypass patients: a historic cohort study. Surg Obes Relat Dis. 2016;12:246-52.
79. Kang X, Zurita-Macias L, Hong D, Cadeddu M, Anvari M, Gmora S. A comparison of 30-day versus 90-day proton pump inhibitor therapy in prevention of marginal ulcers after laparoscopic Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2016;12:1003-7.
80. Wennerlund J, Gunnarsson U, Strigård K, Sundbom M. Acid-related complications after laparoscopic Roux-en-Y gastric bypass: risk factors and impact of proton pump inhibitors. Surg Obes Relat Dis. 2020;16:620-5.
81. Watkinson G, Hopkins A, Akbar FA. The therapeutic efficacy of misoprostol in peptic ulcer disease. Postgrad Med J. 1988;64 Suppl 1:60-77.
82. Walt RP. Misoprostol for the treatment of peptic ulcer and antiinflammatory-drug-induced gastroduodenal ulceration. N Engl J Med. 1992;327:1575-80.
83. Ma P, Ghiassi S, Lloyd A, et al. Reversal of Roux en Y gastric bypass: largest single institution experience. Surg Obes Relat Dis. 2019;15:1311-6.
84. Chau E, Youn H, Ren-Fielding CJ, Fielding GA, Schwack BF, Kurian MS. Surgical management and outcomes of patients with marginal ulcer after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2015;11:1071-5.
85. Patel RA, Brolin RE, Gandhi A. Revisional operations for marginal ulcer after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2009;5:317-22.
86. Debas HT, Carvajal SH. Vagal regulation of acid secretion and gastrin release. Yale J Biol Med. 1994;67:145-151.
87. Weinstein VA, Colp R. Supradiaphragmatic vagotomy in gastrojejunal ulceration following subtotal gastrectomy for duodenal ulcer. Surg Clin North Am. 1947;27:249-53.
88. Birriel TJ, El Chaar M. Laparoscopic revision of chronic marginal ulcer and bilateral truncal vagotomy. Surg Obes Relat Dis. 2016;12:443-4.
89. Brungardt J, Tracy B, McBride K, Standiford D, Bailey BM. Right robotic-assisted transthoracic truncal vagotomy for marginal ulcer disease after gastric bypass surgery. Am Surg. 2018;84:e340-2.
90. Bonanno A, Tieu B, Dewey E, Husain F. Thoracoscopic truncal vagotomy versus surgical revision of the gastrojejunal anastomosis for recalcitrant marginal ulcers. Surg Endosc. 2019;33:607-11.
91. Hunter J, Stahl RD, Kakade M, Breitman I, Grams J, Clements RH. Effectiveness of thoracoscopic truncal vagotomy in the treatment of marginal ulcers after laparoscopic Roux-en-Y gastric bypass. Am Surg. 2012;78:663-8.
92. Fecso AB, Di Palma A, Maeda A, Englesakis M, Jackson T, Okrainec A. Operative management of recalcitrant marginal ulcers following laparoscopic Roux-en-Y gastric bypass for morbid obesity: a systematic review. Surg Obes Relat Dis. 2021;17:2082-90.
