REFERENCES

1. Wang H, Mehal W, Nagy LE, Rotman Y. Immunological mechanisms and therapeutic targets of fatty liver diseases. Cell Mol Immunol 2021;18:73-91.

2. Åberg F, Färkkilä M. Drinking and obesity: alcoholic liver disease/nonalcoholic fatty liver disease interactions. Semin Liver Dis 2020;40:154-62.

3. Parker R, Kim SJ, Gao B. Alcohol, adipose tissue and liver disease: mechanistic links and clinical considerations. Nat Rev Gastroenterol Hepatol 2018;15:50-9.

4. Fan X, Liu Z, Poulsen KL, et al. Alcohol consumption is associated with poor prognosis in obese patients with COVID-19: a mendelian randomization study using UK biobank. Nutrients 2021;13:1592.

5. Lonardo A, Singal AK, Osna N, Kharbanda KK. Effect of cofactors on NAFLD/NASH and MAFLD. A paradigm illustrating the pathomechanics of organ dysfunction. Metab Target Organ Damage 2022;2:12.

6. Kim A, Mccullough RL, Poulsen KL, et al. Hepatic immune system: adaptations to alcohol. In: Grant KA, Lovinger DM, editors. The neuropharmacology of alcohol. Cham: Springer International Publishing; 2018. p. 347-67.

7. Szabo G, Saha B. Alcohol’s effect on host defense. Alcohol Res 2015;37:159-70.

8. Pasala S, Barr T, Messaoudi I. Impact of alcohol abuse on the adaptive immune system. Alcohol Res 2015;37:185-97.

9. Laso FJ, Madruga JI, Girón JA, et al. Decreased natural killer cytotoxic activity in chronic alcoholism is associated with alcohol liver disease but not active ethanol consumption. Hepatology 1997;25:1096-100.

10. Støy S, Dige A, Sandahl TD, et al. Cytotoxic T lymphocytes and natural killer cells display impaired cytotoxic functions and reduced activation in patients with alcoholic hepatitis. Am J Physiol Gastrointest Liver Physiol 2015;308:G269-76.

11. Bartel Y, Bauer B, Steinle A. Modulation of NK cell function by genetically coupled C-type lectin-like receptor/ligand pairs encoded in the human natural killer gene complex. Front Immunol 2013;4:362.

12. Byun JS, Jeong WI. Involvement of hepatic innate immunity in alcoholic liver disease. Immune Netw 2010;10:181-7.

13. Welte S, Kuttruff S, Waldhauer I, Steinle A. Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction. Nat Immunol 2006;7:1334-42.

14. Voskoboinik I, Whisstock JC, Trapani JA. Perforin and granzymes: function, dysfunction and human pathology. Nat Rev Immunol 2015;15:388-400.

15. Sparrow E, Bodman-Smith MD. Granulysin: the attractive side of a natural born killer. Immunol Lett 2020;217:126-32.

16. Takata H, Takiguchi M. Three memory subsets of human CD8+ T cells differently expressing three cytolytic effector molecules. J Immunol 2006;177:4330-40.

17. Li S, Tan HY, Wang N, Feng Y, Wang X, Feng Y. Recent insights into the role of immune cells in alcoholic liver disease. Front Immunol 2019;10:1328.

18. Cuff AO, Sillito F, Dertschnig S, et al. The obese liver environment mediates conversion of NK cells to a less cytotoxic ILC1-like phenotype. Front Immunol 2019;10:2180.

19. Stiglund N, Strand K, Cornillet M, et al. Retained NK cell phenotype and functionality in non-alcoholic fatty liver disease. Front Immunol 2019;10:1255.

20. Carpino G, Del Ben M, Pastori D, et al. Increased liver localization of lipopolysaccharides in human and experimental NAFLD. Hepatology 2020;72:470-85.

21. Männistö V, Färkkilä M, Pussinen P, et al. Serum lipopolysaccharides predict advanced liver disease in the general population. JHEP Rep 2019;1:345-52.

22. Bala S, Marcos M, Gattu A, Catalano D, Szabo G. Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals. PLoS One 2014;9:e96864.

23. Kim A, Bellar A, McMullen MR, Li X, Nagy LE. Functionally diverse inflammatory responses in peripheral and liver monocytes in alcohol-associated hepatitis. Hepatol Commun 2020;4:1459-76.

24. Kim A, Saikia P, Nagy LE. miRNAs involved in M1/M2 hyperpolarization are clustered and coordinately expressed in alcoholic hepatitis. Front Immunol 2019;10:1295.

25. Stuart T, Butler A, Hoffman P, et al. Comprehensive integration of single-cell data. Cell 2019;177:1888-1902.e21.

26. Hafemeister C, Satija R. Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression. Genome Biol 2019;20:296.

27. Ding J, Adiconis X, Simmons SK, et al. Systematic comparative analysis of single cell RNA-sequencing methods. bioRxiv 2019.

28. Iacono G, Mereu E, Guillaumet-Adkins A, et al. bigSCale: an analytical framework for big-scale single-cell data. Genome Res 2018;28:878-90.

29. Braud VM, Allan DS, O’Callaghan CA, et al. HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C. Nature 1998;391:795-9.

30. Voss JK, Li Z, Weinman SA. Elevated blood monocyte counts in alcohol-associated hepatitis. JGH Open 2022;6:148-51.

31. Saikia P, Roychowdhury S, Bellos D, et al. Hyaluronic acid 35 normalizes TLR4 signaling in Kupffer cells from ethanol-fed rats via regulation of microRNA291b and its target Tollip. Sci Rep 2017;7:15671.

32. Kim A, Wu X, Allende DS, Nagy LE. Gene deconvolution reveals aberrant liver regeneration and immune cell infiltration in alcohol-associated hepatitis. Hepatology 2021;74:987-1002.

33. Herndler-Brandstetter D, Ishigame H, Shinnakasu R, et al. KLRG1+ effector CD8+ T cells lose KLRG1, differentiate into all memory t cell lineages, and convey enhanced protective immunity. Immunity 2018;48:716-729.e8.

34. Perišić Nanut M, Sabotič J, Jewett A, Kos J. Cysteine cathepsins as regulators of the cytotoxicity of NK and T cells. Front Immunol 2014;5:616.

35. Mathur K, Vilar-Gomez E, Connelly MA, et al. Circulating high density lipoprotein distinguishes alcoholic hepatitis from heavy drinkers and predicts 90-day outcome: lipoproteins in alcoholic hepatitis. J Clin Lipidol 2021;15:805-13.

36. Ciocan D, Voican CS, Wrzosek L, et al. Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis. Aliment Pharmacol Ther 2018;48:961-74.

37. Gao B, Duan Y, Lang S, et al. Functional microbiomics reveals alterations of the gut microbiome and host co-metabolism in patients with alcoholic hepatitis. Hepatol Commun 2020;4:1168-82.

Metabolism and Target Organ Damage
ISSN 2769-6375 (Online)
Follow Us

Portico

All published articles are preserved here permanently:

https://www.portico.org/publishers/oae/

Portico

All published articles are preserved here permanently:

https://www.portico.org/publishers/oae/