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Figure 3. Obesity-associated functional remodeling involves differences in strain-level enzyme variant distribution and variant-cluster richness. Bar plots show the mean ± standard deviation of genetic variant clusters detected per sample for the three BMI-associated enzymatic functions. Kruskal-Wallis P values are reported above the plots. The accompanying tables indicate the species carrying each variant and the proportion of strains harboring it. The three heatmaps display the percentage change in the prevalence of each variant in the obese group relative to the arithmetic mean prevalence across the normal-weight, overweight, and obese groups. BCAA: Branched-chain amino acid; BMI: body mass index.