fig5

Figure 5. Faecal metabolome derived from human patients with colorectal cancer (n = 5). (A) Categories of the metabolites detected in human faeces. For definitions of the abbreviated metabolite names refer to the legend of Figure 2; (B) Venn diagram of faecal metabolites detected in Ex-GF mice and humans; (C) Detection of metabolites altered by endoscopic resection in patient No. 1. Metabolites whose concentrations increased or decreased by more than five-fold before and after endoscopic treatment are shown. Values for metabolites that were undetected before treatment but detected after treatment, and for metabolites detected before treatment but undetected after treatment, were assigned 10 and -10, respectively. Supplementary Table 6 shows the detailed metabolites and levels of change of all metabolites, including unchanged metabolites. PtdE: Phosphatidylethanolamine; PtdC: phosphatidylcholine; PtdI: phosphatidylinositol; PtdG: phosphatidylglycerol; LPtdE: lysophosphatidylethanolamine; PtdS: phosphatidylserine; LPtdC: lysophosphatidylcholine; LPtdG: lysophosphatidylglycerol; SM: sphingomyelin; LPtdS: lysophosphatidylserine; LPtdC: lysophosphatidylcholine; LPtdI: lysophosphatidylinositol; AA: arachidonic acid; DHA: docosahexaenoic acid; EPA: eicosapentaenoic acid; LA: Linoleic acid; EA: ethanolamide; EDA: eicosadienoic acid; D-AA: D-amino acid; L-AA: L-amino acid.