fig2
From: Recent advances in gut microbiota-mediated regulation of fat deposition and metabolic disorders
Figure 2. Mechanisms of gut microbiota regulation of fat deposition in chickens and pigs. This primarily includes four aspects: SCFAs inhibit lipogenesis; secondary bile acids bind TGR5 to promote thermogenesis; LPS triggers TLR4-NF-κB-driven inflammation; and BCAAs activate mTORC1 to stimulate adipogenesis. SCFAs: Short-chain fatty acids; LPS: lipopolysaccharide; NF-κB: nuclear factor-kappa B; BCAAs: branched-chain amino acids; mTORC1: mechanistic target of rapamycin complex 1.
