REFERENCES
1. Golebiowska, A. A.; Intravaia, J. T.; Sathe, V. M.; Kumbar, S. G.; Nukavarapu, S. P. Decellularized extracellular matrix biomaterials for regenerative therapies: advances, challenges and clinical prospects. Bioact. Mater. 2024, 32, 98-123.
2. Xu, M.; Su, T.; Jin, X.; et al. Inflammation-mediated matrix remodeling of extracellular matrix-mimicking biomaterials in tissue engineering and regenerative medicine. Acta. Biomater. 2022, 151, 106-17.
3. Majumder, J.; Taratula, O.; Minko, T. Nanocarrier-based systems for targeted and site specific therapeutic delivery. Adv. Drug. Deliv. Rev. 2019, 144, 57-77.
4. Zhao, Z.; Ukidve, A.; Kim, J.; Mitragotri, S. Targeting strategies for tissue-specific drug delivery. Cell 2020, 181, 151-67.
5. Hannafon, B. N.; Ding, W. Q. Intercellular communication by exosome-derived microRNAs in cancer. Int. J. Mol. Sci. 2013, 14, 14240-69.
6. Bhatnagar, D.; Simon, M.; Rafailovich, M. H. Hydrogels for regenerative medicine. In: Parveen FK, editors. Recent advances in biopolymers. InTech; 2016.
7. Chen, Y.; Wang, X.; Tao, S.; et al. Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties. Mil. Med. Res. 2023, 10, 37.
8. Liu, M.; Zeng, X.; Ma, C.; et al. Injectable hydrogels for cartilage and bone tissue engineering. Bone. Res. 2017, 5, 17014.
9. Zhao, X.; Lang, Q.; Yildirimer, L.; et al. Photocrosslinkable gelatin hydrogel for epidermal tissue engineering. Adv. Healthc. Mater. 2016, 5, 108-18.
10. Levingstone, T. J.; Matsiko, A.; Dickson, G. R.; O'Brien, F. J.; Gleeson, J. P. A biomimetic multi-layered collagen-based scaffold for osteochondral repair. Acta. Biomater. 2014, 10, 1996-2004.
11. Manferdini, C.; Cavallo, C.; Grigolo, B.; et al. Specific inductive potential of a novel nanocomposite biomimetic biomaterial for osteochondral tissue regeneration. J. Tissue. Eng. Regen. Med. 2016, 10, 374-91.
12. Jella, K. K.; Nasti, T. H.; Li, Z.; Malla, S. R.; Buchwald, Z. S.; Khan, M. K. Exosomes, their biogenesis and role in inter-cellular communication, tumor microenvironment and cancer immunotherapy. Vaccines 2018, 6, 69.
13. Liu, J.; Ren, L.; Li, S.; et al. The biology, function, and applications of exosomes in cancer. Acta. Pharm. Sin. B. 2021, 11, 2783-97.
14. Wu, J.; Chen, L. H.; Sun, S. Y.; Li, Y.; Ran, X. W. Mesenchymal stem cell-derived exosomes: the dawn of diabetic wound healing. World. J. Diabetes. 2022, 13, 1066-95.
15. Wang, X.; Chen, Y.; Zhao, Z.; et al. Engineered exosomes with ischemic myocardium-targeting peptide for targeted therapy in myocardial infarction. J. Am. Heart. Assoc. 2018, 7, e008737.
16. Hu, S.; Qiao, L.; Cheng, K. Generation and manipulation of exosomes. Methods. Mol. Biol. 2021, 2158, 295-305.
17. Liu, R. H.; Ning, B.; Ma, X. E.; Gong, W. M.; Jia, T. H. Regulatory roles of microRNA-21 in fibrosis through interaction with diverse pathways (Review). Mol. Med. Rep. 2016, 13, 2359-66.
18. Lv, Q.; Deng, J.; Chen, Y.; Wang, Y.; Liu, B.; Liu, J. Engineered human adipose stem-cell-derived exosomes loaded with miR-21-5p to promote diabetic cutaneous wound healing. Mol. Pharm. 2020, 17, 1723-33.
19. Li, D.; Zhang, C.; Gao, Z.; et al. Curcumin-loaded macrophage-derived exosomes effectively improve wound healing. Mol. Pharm. 2023, 20, 4453-67.
20. Puthia, M.; Butrym, M.; Petrlova, J.; et al. A dual-action peptide-containing hydrogel targets wound infection and inflammation. Sci. Transl. Med. 2020, 12, eaax6601.
21. Selvadoss, A.; Baby, H. M.; Zhang, H.; Bajpayee, A. G. Harnessing exosomes for advanced osteoarthritis therapy. Nanoscale 2024, 16, 19174-91.
22. Garbern, J. C.; Minami, E.; Stayton, P. S.; Murry, C. E. Delivery of basic fibroblast growth factor with a pH-responsive, injectable hydrogel to improve angiogenesis in infarcted myocardium. Biomaterials 2011, 32, 2407-16.
23. Li, L.; Xiao, B.; Mu, J.; et al. A MnO2 Nanoparticle-dotted hydrogel promotes spinal cord repair via regulating reactive oxygen species microenvironment and synergizing with mesenchymal stem cells. ACS. Nano. 2019, 13, 14283-93.
24. Chen, J.; Pan, C.; Gao, Y.; Chen, Q.; An, X.; Liu, Z. Reactive oxygen species scavenging injectable hydrogel potentiates the therapeutic potential of mesenchymal stem cells in skin flap regeneration. ACS. Appl. Mater. Interfaces. 2024, 16, 17120-8.
25. Kwak, G.; Cheng, J.; Kim, H.; et al. Sustained exosome‐guided macrophage polarization using hydrolytically degradable PEG Hydrogels for cutaneous wound healing: identification of key proteins and MiRNAs, and sustained release formulation. Small 2022, 18, 2200060.
26. Fan, M.; Pi, J.; Zou, C.; et al. Hydrogel-exosome system in tissue engineering: a promising therapeutic strategy. Bioact. Mater. 2024, 38, 1-30.
27. Du, S.; Zhou, X.; Zheng, B. Beyond traditional medicine: EVs-loaded hydrogels as a game changer in disease therapeutics. Gels 2024, 10, 162.
28. Cao, J.; Wu, B.; Yuan, P.; Liu, Y.; Hu, C. Advances in research of hydrogel microneedle-based delivery systems for disease treatment. Pharmaceutics 2024, 16, 1571.
29. Nelson, B. C.; Maragh, S.; Ghiran, I. C.; et al. Measurement and standardization challenges for extracellular vesicle therapeutic delivery vectors. Nanomed 2020, 15, 2149-70.
30. Li, S.; Tian, X.; Fan, J.; Tong, H.; Ao, Q.; Wang, X. Chitosans for tissue repair and organ three-dimensional (3D) bioprinting. Micromachines 2019, 10, 765.
31. Liu, X.; Ma, L.; Mao, Z.; Gao, C. Chitosan-based biomaterials for tissue repair and regeneration. In Chitosan for biomaterials II. Berlin, Heidelberg: Springer Berlin Heidelberg; 2011. pp. 81-127.
32. Wang, C.; Liang, C.; Wang, R.; et al. The fabrication of a highly efficient self-healing hydrogel from natural biopolymers loaded with exosomes for the synergistic promotion of severe wound healing. Biomater. Sci. 2020, 8, 313-24.
33. Yue, K.; Trujillo-de, Santiago. G.; Alvarez, M. M.; Tamayol, A.; Annabi, N.; Khademhosseini, A. Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels. Biomaterials 2015, 73, 254-71.
34. Hassannejad, Z.; Zadegan, S. A.; Vaccaro, A. R.; Rahimi-Movaghar, V.; Sabzevari, O. Biofunctionalized peptide-based hydrogel as an injectable scaffold for BDNF delivery can improve regeneration after spinal cord injury. Injury 2019, 50, 278-85.
35. Yu, Z.; Li, Q.; He, X.; et al. A multifunctional hydrogel based on nature polysaccharide fabricated by Schiff base reaction. Eur. Polym. J. 2023, 197, 112330.
36. Singh, R.; Malhotra, H.; Jadhav, K.; et al. Intelligently actuating dual-barrier hyaluronic acid-functionalized inflammation-responsive nanohydrogel for targeted rheumatoid arthritis therapy. ACS. Appl. Mater. Interfaces. 2025, 17, 40012-34.
37. Jaquilin, P. J. R.; Oluwafemi, O. S.; Thomas, S.; Oyedeji, A. O. Recent advances in drug delivery nanocarriers incorporated in temperature-sensitive Pluronic F-127-A critical review. J. Drug. Deliv. Sci. Technol. 2022, 72, 103390.
38. Shriky, B.; Kelly, A.; Isreb, M.; et al. Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development. J. Colloid. Interface. Sci. 2020, 565, 119-30.
39. O'connell, C. D.; Zhang, B.; Onofrillo, C.; et al. Tailoring the mechanical properties of gelatin methacryloyl hydrogels through manipulation of the photocrosslinking conditions. Soft. Matter. 2018, 14, 2142-51.
40. Piccolo, L.; Bornillo, K.; Micheli, S.; et al. A penetration efficiency model for the optimization of solid conical microneedles’ geometry. J. Micromech. Microeng. 2024, 34, 025009.
41. Abdullah, A. C.; Ahmadinejad, E.; Tasoglu, S. Optimizing solid microneedle design: a comprehensive ML-augmented DOE approach. ACS. Meas. Sci. Au. 2024, 4, 504-14.
42. Grenier, J.; Duval, H.; Lv, P.; et al. Interplay between crosslinking and ice nucleation controls the porous structure of freeze-dried hydrogel scaffolds. Biomater. Adv. 2022, 139, 212973.
43. Grenier, J.; Duval, H.; Barou, F.; Lv, P.; David, B.; Letourneur, D. Mechanisms of pore formation in hydrogel scaffolds textured by freeze-drying. Acta. Biomater. 2019, 94, 195-203.
44. Sun, D.; Zhuang, X.; Xiang, X.; et al. A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Mol. Ther. 2010, 18, 1606-14.
45. Perez, R. A.; Kim, H. Core-shell designed scaffolds for drug delivery and tissue engineering. Acta. Biomater. 2015, 21, 2-19.
46. Gupta, D.; Singh, A. K.; Bellare, J. Natural bone inspired core-shell triple-layered gel/PCL/gel 3D printed scaffolds for bone tissue engineering. Biomed. Mater. 2023, 18, 065027.
47. Qi, H.; Wang, B.; Wang, M.; Xie, H.; Chen, C. A pH/ROS-responsive antioxidative and antimicrobial GelMA hydrogel for on-demand drug delivery and enhanced osteogenic differentiation in vitro. Int. J. Pharm. 2024, 657, 124134.
48. Allen, Jr. RJ, Soares MA, Haberman ID, et al. Combination therapy accelerates diabetic wound closure. PLoS. ONE. 2014, 9, e92667.
49. Wang, Y.; Wu, Y.; Long, L.; et al. Inflammation-responsive drug-loaded hydrogels with sequential hemostasis, antibacterial, and anti-inflammatory behavior for chronically infected diabetic wound treatment. ACS. Appl. Mater. Interfaces. 2021, 13, 33584-99.
50. Wang, C.; Wang, M.; Xu, T.; et al. Engineering bioactive self-healing antibacterial exosomes hydrogel for promoting chronic diabetic wound healing and complete skin regeneration. Theranostics 2019, 9, 65-76.
51. Zhang, X.; Liu, Y.; Wang, Z.; et al. pH-responsive and self-adaptive injectable sodium alginate/carboxymethyl chitosan hydrogel accelerates infected wound healing by bacteriostasis and immunomodulation. Carbohydr. Polym. 2025, 354, 123322.
52. Zhao, H.; Huang, J.; Li, Y.; et al. ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds. Biomaterials 2020, 258, 120286.
53. Han, D.; Morde, R. S.; Mariani, S.; et al. 4D printing of a bioinspired microneedle array with backward‐facing barbs for enhanced tissue adhesion. Adv. Funct. Mater. 2020, 30, 1909197.
54. Detamornrat, U.; Mcalister, E.; Hutton, A. R. J.; Larrañeta, E.; Donnelly, R. F. The role of 3D printing technology in microengineering of microneedles. Small. 2022, 18, 2106392.
55. Li, R.; Zhang, L.; Jiang, X.; et al. 3D-printed microneedle arrays for drug delivery. J. Controlled. Release. 2022, 350, 933-48.
56. Zhou, X.; Esworthy, T.; Lee, S.; et al. 3D printed scaffolds with hierarchical biomimetic structure for osteochondral regeneration. Nanomed. Nanotechnol. Biol. Med. 2019, 19, 58-70.
57. Ren, Y.; Zhang, C.; Liu, Y.; et al. Advances in 3D printing of highly bioadaptive bone tissue engineering scaffolds. ACS. Biomater. Sci. Eng. 2023, 10, 255-70.
58. Sharun, K.; Banu, S. A.; Mamachan, M.; et al. Thermoresponsive and injectable pluronic F127 hydrogel for loading adipose-derived mesenchymal stem cells. Discov. Med. 2024, 36, 294.
59. Ozkan, O.; Sasmazel, H. T. Antibacterial performance of PCL-chitosan core-shell scaffolds. J. Nanosci. Nanotechnol. 2018, 18, 2415-21.
60. Guvendiren, M.; Lu, H. D.; Burdick, J. A. Shear-thinning hydrogels for biomedical applications. Soft. Matter. 2012, 8, 260-72.
61. Zeitter, S.; Sikora, Z.; Jahn, S.; et al. Microneedling: matching the results of medical needling and repetitive treatments to maximize potential for skin regeneration. Burns 2014, 40, 966-73.
62. Zhu, Y. F.; He, M. Q.; Lin, C. S.; et al. Multifunctional nanocarrier drug delivery systems: from diverse design to precise biomedical applications. Adv. Healthcare. Mater. 2025, 15, e02178.
63. Su, F.; Wang, Y.; Liu, X.; et al. Biocompatibility and in vivo degradation of chitosan based hydrogels as potential drug carrier. J. Biomater. Sci. Polym. Ed. 2018, 29, 1515-28.
64. Wang, X.; Song, R.; Johnson, M.; et al. An injectable chitosan-based self-healable hydrogel system as an antibacterial wound dressing. Materials 2021, 14, 5956.
65. Yuan, J.; Yang, H.; Liu, C.; et al. Microneedle patch loaded with exosomes containing MicroRNA‐29b prevents cardiac fibrosis after myocardial infarction. Adv. Healthcare. Mater. 2023, 12, 2202959.
66. Yu, X.; Pan, Q.; Zheng, Z.; et al. pH-responsive and porous vancomycin-loaded PLGA microspheres: evidence of controlled and sustained release for localized inflammation inhibition in vitro. RSC. Adv. 2018, 8, 37424-32.
67. Shiekh, P. A.; Singh, A.; Kumar, A. Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing. Biomaterials 2020, 249, 120020.
68. Chen, M. H.; Wang, L. L.; Chung, J. J.; Kim, Y.; Atluri, P.; Burdick, J. A. Methods to assess shear-thinning hydrogels for application as injectable biomaterials. ACS. Biomater. Sci. Eng. 2017, 3, 3146-60.
69. Ahmadi, Z.; Yadav, S.; Kar, A. K.; et al. An injectable self-assembling hydrogel based on RGD peptidomimetic β-sheets as multifunctional biomaterials. Biomater. Adv. 2022, 133, 112633.
70. Roma-Rodrigues, C.; Raposo, L.; Cabral, R.; Paradinha, F.; Baptista, P.; Fernandes, A. Tumor microenvironment modulation via gold nanoparticles targeting malicious exosomes: implications for cancer diagnostics and therapy. Int. J. Mol. Sci. 2017, 18, 162.
71. Zhou, J.; Wang, M.; Ying, H.; et al. Extracellular matrix component shelled nanoparticles as dual enzyme-responsive drug delivery vehicles for cancer therapy. ACS. Biomater. Sci. Eng. 2018, 4, 2404-11.
72. Liang, C.; Wang, R.; He, T.; et al. Revolutionizing diabetic wound healing: the power of microneedles. Chinese. J. Plastic. Reconstruct. Surgery. 2023, 5, 185-94.
73. Sun, Q.; Tao, S.; Bovone, G.; et al. Versatile mechanically tunable hydrogels for therapeutic delivery applications. Adv. Healthcare. Mater. 2024, 13, 2304287.
74. Xu, X.; Saw, P. E.; Tao, W.; et al. ROS‐responsive polyprodrug nanoparticles for triggered drug delivery and effective cancer therapy. Adv. Mater. 2017, 29, 1700141.
75. Hui, L.; Qin, S.; Yang, L. Upper critical solution temperature polymer, photothermal agent, and erythrocyte membrane coating: an unexplored recipe for making drug carriers with spatiotemporally controlled cargo release. ACS. Biomater. Sci. Eng. 2016, 2, 2127-32.
76. Martinez, J. O.; Chiappini, C.; Ziemys, A.; et al. Engineering multi-stage nanovectors for controlled degradation and tunable release kinetics. Biomaterials 2013, 34, 8469-77.
77. Yang, G.; Waheed, S.; Wang, C.; Shekh, M.; Li, Z.; Wu, J. Exosomes and their bioengineering strategies in the cutaneous wound healing and related complications: current knowledge and future perspectives. Int. J. Biol. Sci. 2023, 19, 1430-54.
78. Su, Z.; Chen, M.; Xiao, Y.; et al. ROS-triggered and regenerating anticancer nanosystem: an effective strategy to subdue tumor's multidrug resistance. J. Controlled. Release. 2014, 196, 370-83.
79. Sun, J.; Ju, F.; Jin, J.; et al. M2 macrophage membrane-mediated biomimetic-nanoparticle carrying COX‐siRNA targeted delivery for prevention of tendon adhesions by inhibiting inflammation. Small 2023, 19, 2300326.
80. Yang, J.; Chen, Y.; Li, Y.; Yin, X. Magnetic resonance imaging-guided multi-drug chemotherapy and photothermal synergistic therapy with pH and NIR-stimulation release. ACS. Appl. Mater. Interfaces. 2017, 9, 22278-88.
81. Yang, C.; Liu, X.; Zhao, K.; et al. miRNA-21 promotes osteogenesis via the PTEN/PI3K/Akt/HIF-1α pathway and enhances bone regeneration in critical size defects. Stem. Cell. Res. Ther. 2019, 10, 65.
82. Fu, M.; Fang, L.; Xiang, X.; Fan, X.; Wu, J.; Wang, J. Microarray analysis of circRNAs sequencing profile in exosomes derived from bone marrow mesenchymal stem cells in postmenopausal osteoporosis patients. J. Clin. Lab. Anal. 2021, 36, e23916.
83. Wang, X.; Zhou, Y.; Gao, Q.; et al. The role of exosomal microRNAs and oxidative stress in neurodegenerative diseases. Oxid. Med. Cell. Longev. 2020, 2020, 1-17.
84. Zhou, X.; Ye, C.; Jiang, L.; et al. The bone mesenchymal stem cell-derived exosomal miR-146a-5p promotes diabetic wound healing in mice via macrophage M1/M2 polarization. Mol. Cell. Endocrinol. 2024, 579, 112089.
85. Boccardo, S.; Gaudiello, E.; Melly, L.; et al. Engineered mesenchymal cell-based patches as controlled VEGF delivery systems to induce extrinsic angiogenesis. Acta. Biomater. 2016, 42, 127-35.
86. Joo, H. S.; Suh, J. H.; Lee, H. J.; Bang, E. S.; Lee, J. M. Current knowledge and future perspectives on mesenchymal stem cell-derived exosomes as a new therapeutic agent. Int. J. Mol. Sci. 2020, 21, 727.
87. Marote, A.; Teixeira, F. G.; Mendes-pinheiro, B.; Salgado, A. J. MSCs-derived exosomes: cell-secreted nanovesicles with regenerative potential. Front. Pharmacol. 2016, 7, 231.
88. Xue, C.; Shen, Y.; Li, X.; et al. Exosomes derived from hypoxia-treated human adipose mesenchymal stem cells enhance angiogenesis through the PKA signaling pathway. Stem. Cells. Dev. 2018, 27, 456-65.
89. Zhu, F.; Chen, Y.; Li, J.; et al. Human umbilical cord mesenchymal stem cell‐derived exosomes attenuate myocardial infarction injury via miR‐24‐3p‐promoted M2 macrophage polarization. Adv. Biol. 2022, 6, 2200074.
90. Sahoo, S.; Losordo, D. W. Exosomes and cardiac repair after myocardial infarction. Circ. Res. 2014, 114, 333-44.
91. Liu, W.; Feng, Y.; Wang, X.; et al. Human umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway. Bioengineered 2022, 13, 8850-65.
92. Ribeiro-Rodrigues, T. M.; Laundos, T. L.; Pereira-Carvalho, R.; et al. Exosomes secreted by cardiomyocytes subjected to ischaemia promote cardiac angiogenesis. Cardiovasc. Res. 2017, 113, 1338-50.
93. Hsu, H.; Wang, A. Y. L.; Loh, C. Y. Y.; Pai, A. A.; Kao, H. Therapeutic potential of exosomes derived from diabetic adipose stem cells in cutaneous wound healing of db/db mice. Pharmaceutics 2022, 14, 1206.
94. Zhao, B.; Zhang, X.; Zhang, Y.; et al. Human exosomes accelerate cutaneous wound healing by promoting collagen synthesis in a diabetic mouse model. Stem. Cells. Dev. 2021, 30, 922-33.
95. Tao, S.; Yuan, T.; Zhang, Y.; Yin, W.; Guo, S.; Zhang, C. Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model. Theranostics 2017, 7, 180-95.
96. Shen, Y.; Cai, J. The importance of using exosome-loaded miRNA for the treatment of spinal cord injury. Mol. Neurobiol. 2022, 60, 447-59.
97. Feng, J.; Zhang, Y.; Zhu, Z.; Gu, C.; Waqas, A.; Chen, L. Emerging exosomes and exosomal MiRNAs in spinal cord injury. Front. Cell. Dev. Biol. 2021, 9, 703989.
98. Whiteside, T. L. Exosomes and tumor-mediated immune suppression. J. Clin. Investig. 2016, 126, 1216-23.
99. Tan, S.; Xia, L.; Yi, P.; et al. Exosomal miRNAs in tumor microenvironment. J. Exp. Clin. Cancer. Res. 2020, 39, 67.
100. Sato, K.; Meng, F.; Glaser, S.; Alpini, G. Exosomes in liver pathology. J. Hepatol. 2016, 65, 213-21.
101. Jiao, Y.; Xu, P.; Shi, H.; Chen, D.; Shi, H. Advances on liver cell‐derived exosomes in liver diseases. J. Cell. Mol. Med. 2020, 25, 15-26.
102. Prasai, A.; Jay, J. W.; Jupiter, D.; Wolf, S. E.; El, Ayadi. A. Role of exosomes in dermal wound healing: a systematic review. J. Investig. Dermatol. 2022, 142, 662-78.e8.
103. Zhou, X.; Brown, B. A.; Siegel, A. P.; et al. Exosome-mediated crosstalk between keratinocytes and macrophages in cutaneous wound healing. ACS. Nano. 2020, 14, 12732-48.
104. Sabapatha, A.; Gercel‐taylor, C.; Taylor, D. D. Specific isolation of placenta‐derived exosomes from the circulation of pregnant women and their immunoregulatory consequences. Am. J. Reprod. Immunol. 2006, 56, 345-55.
105. Chang, X.; Yao, J.; He, Q.; Liu, M.; Duan, T.; Wang, K. Exosomes from women with preeclampsia induced vascular dysfunction by delivering sFlt (soluble Fms-like tyrosine kinase)-1 and sEng (soluble endoglin) to endothelial cells. Hypertension 2018, 72, 1381-90.
107. Miyanishi, M.; Tada, K.; Koike, M.; Uchiyama, Y.; Kitamura, T.; Nagata, S. Identification of Tim4 as a phosphatidylserine receptor. Nature 2007, 450, 435-9.
109. Zhou, Y.; Bréchard, S. Neutrophil extracellular vesicles: a delicate balance between pro-inflammatory responses and anti-inflammatory therapies. Cells 2022, 11, 3318.
110. Alexander, M.; O'connell, R. Exosomal miRNAs regulate inflammatory responses (IRM11P.624). J. Immunol. 2015, 194, 132.3.
111. Maderna, P.; Cottell, D. C.; Toivonen, T.; et al. FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin‐derived peptide‐stimulated phagocytosis. FASEB. J. 2010, 24, 4240-9.
112. Loynes, C. A.; Lee, J. A.; Robertson, A. L.; et al. PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo. Sci. Adv. 2018, 4, eaar8320.
113. Liu, Q.; Li, D.; Pan, X.; Liang, Y. Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification. J. Nanobiotechnol. 2023, 21, 334.
114. Sun, J.; Shen, H.; Shao, L.; et al. HIF-1α overexpression in mesenchymal stem cell-derived exosomes mediates cardioprotection in myocardial infarction by enhanced angiogenesis. Stem. Cell. Res. Ther. 2020, 11, 373.
115. Larsimont, J.; Youssef, K. K.; Sánchez-Danés, A.; et al. Sox9 controls self-renewal of oncogene targeted cells and links tumor initiation and invasion. Cell. Stem. Cell. 2015, 17, 60-73.
116. Mattheolabakis, G.; Milane, L.; Singh, A.; Amiji, M. M. Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine. J. Drug. Targeting. 2015, 23, 605-18.
117. Meng, L.; Wang, C.; Lu, Y.; et al. Targeted regulation of blood-brain barrier for enhanced therapeutic efficiency of hypoxia-modifier nanoparticles and immune checkpoint blockade antibodies for glioblastoma. ACS. Appl. Mater. Interfaces. 2021, 13, 11657-71.
118. Kim, S.; Rait, A.; Kim, E.; Demarco, J.; Pirollo, K. F.; Chang, E. H. Encapsulation of temozolomide in a tumor-targeting nanocomplex enhances anti-cancer efficacy and reduces toxicity in a mouse model of glioblastoma. Cancer. Lett. 2015, 369, 250-8.
119. Hsu, Y.; Acuña, M.; Tahara, S. M.; Peng, C. Reduced phagocytosis of colloidal carriers using soluble CD47. Pharm. Res. 2003, 20, 1539-42.
120. Zhang, X.; Wang, C.; Wang, J.; et al. PD‐1 blockade cellular vesicles for cancer immunotherapy. Adv. Mater. 2018, 30, 1707112.
121. Dai, X.; Wang, Z.; Fan, M.; et al. PD-L1 antibodies-armed exosomal vaccine for enhanced cancer immunotherapy by simultaneously in situ activating T cells and blocking PD-1/PD-L1 axis. Extracellular. Vesicle. 2022, 1, 100012.
122. Chao, M. P.; Weissman, I. L.; Majeti, R. The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications. Curr. Opin. Immunol. 2012, 24, 225-32.
123. Kim, D. H.; Kim, H.; Choi, Y. J.; et al. Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer. Exp. Mol. Med. 2019, 51, 1-13.
124. Chen, G.; Huang, A. C.; Zhang, W.; et al. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature 2018, 560, 382-6.
125. Mohammadi, M. R.; Nojoomi, A.; Mozafari, M.; Dubnika, A.; Inayathullah, M.; Rajadas, J. Nanomaterials engineering for drug delivery: a hybridization approach. J. Mater. Chem. B. 2017, 5, 3995-4018.
126. Gomes, E. R.; Carvalho, A. T.; Barbosa, T. C.; et al. Fusion of tumor-derived exosomes with long-circulating and pH-sensitive liposomes loaded with doxorubicin for the treatment of breast cancer. AAPS. PharmSciTech. 2022, 23, 255.
127. Qiao, L.; Hu, S.; Huang, K.; et al. Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs. Theranostics 2020, 10, 3474-87.
128. Barjesteh, T.; Mansur, S.; Bao, Y. Inorganic nanoparticle-loaded exosomes for biomedical applications. Molecules 2021, 26, 1135.
129. Wang, J.; Chen, P.; Dong, Y.; et al. Designer exosomes enabling tumor targeted efficient chemo/gene/photothermal therapy. Biomaterials 2021, 276, 121056.
130. Yang, Y.; Hong, Y.; Nam, G. H.; Chung, J. H.; Koh, E.; Kim, I. S. Virus‐mimetic fusogenic exosomes for direct delivery of integral membrane proteins to target cell membranes. Adv. Mater. 2017, 29, 1605604.
131. Zubarev, I.; Vladimirtsev, D.; Vorontsova, M.; et al. Viral membrane fusion proteins and RNA sorting mechanisms for the molecular delivery by exosomes. Cells 2021, 10, 3043.
132. Hung, M. E.; Leonard, J. N. Stabilization of exosome-targeting peptides via engineered glycosylation. J. Biol. Chem. 2015, 290, 8166-72.
133. Chan, M.; Chang, Z.; Huang, C. F.; Lee, L. J.; Liu, R.; Hsiao, M. Integrated therapy platform of exosomal system: hybrid inorganic/organic nanoparticles with exosomes for cancer treatment. Nanoscale. Horiz. 2022, 7, 352-67.
134. Nie, W.; Wu, G.; Zhang, J.; et al. Responsive exosome nano-bioconjugates for synergistic cancer therapy. Angew. Chem. Int. 2019, 59, 2018-22.
135. Liang, Y.; Xu, X.; Li, X.; et al. Chondrocyte-targeted MicroRNA delivery by engineered exosomes toward a cell-free osteoarthritis therapy. ACS. Appl. Mater. Interfaces. 2020, 12, 36938-47.
136. Fan, L.; Liu, C.; Chen, X.; et al. Exosomes-loaded electroconductive hydrogel synergistically promotes tissue repair after spinal cord injury via immunoregulation and enhancement of myelinated axon growth. Adv. Sci. 2022, 9, 2105586.
137. Chen, Y.; Lin, J.; Yan, W. A Prosperous application of hydrogels with extracellular vesicles release for traumatic brain injury. Front. Neurol. 2022, 13, 908468.
138. Li, S.; Xu, J.; Qian, Y.; Zhang, R. Hydrogel in the treatment of traumatic brain injury. Biomater. Res. 2024, 28, 0085.
139. Arabpour, M.; Saghazadeh, A.; Rezaei, N. Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes. Int. Immunopharmacol. 2021, 97, 107823.
140. Kant, V.; Gopal, A.; Kumar, D.; et al. Curcumin-induced angiogenesis hastens wound healing in diabetic rats. J. Surg. Res. 2015, 193, 978-88.
141. Tan, X.; Zhang, J.; Heng, Y.; et al. Locally delivered hydrogels with controlled release of nanoscale exosomes promote cardiac repair after myocardial infarction. J. Controlled. Release. 2024, 368, 303-17.
142. Peng, H.; Hou, M.; Wu, Z.; et al. Plasma exosomal miR-122 regulates the efficacy of metformin via AMPK in type 2 diabetes and hepatocellular carcinoma. Heliyon 2022, 8, e11503.
143. Morrissey, S. M.; Zhang, F.; Ding, C.; et al. Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming. Cell. Metab. 2021, 33, 2040-58.e10.
144. Mcandrews, K. M.; Che, S. P.; Lebleu, V. S.; Kalluri, R. Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity. J. Biol. Chem. 2021, 296, 100523.
145. Afewerki, S.; Bassous, N.; Harb, S.; et al. Advances in dual functional antimicrobial and osteoinductive biomaterials for orthopaedic applications. Nanomed. Nanotechnol. Biol. Med. 2020, 24, 102143.
146. Wang, H.; Gui, B.; Chen, Y.; et al. Black-phosphorus-reinforced injectable conductive biodegradable hydrogel for the delivery of ADSC-derived exosomes to repair myocardial infarction. ACS. Appl. Mater. Interfaces. 2024, 16, 58286-98.
147. Lyu, S.; Liu, Q.; Yuen, H.; et al. A differential-targeting core-shell microneedle patch with coordinated and prolonged release of mangiferin and MSC-derived exosomes for scarless skin regeneration. Mater. Horiz. 2024, 11, 2667-84.
148. Namazi, H.; Mohit, E.; Namazi, I.; et al. Exosomes secreted by hypoxic cardiosphere‐derived cells enhance tube formation and increase pro‐angiogenic miRNA. J. Cell. Biochem. 2018, 119, 4150-60.
149. Meikle, S.; Piñeiro, Y.; Bañobre, López. M.; Rivas, J.; Santin, M. Surface functionalization superparamagnetic nanoparticles conjugated with thermoresponsive poly(epsilon-lysine) dendrons tethered with carboxybetaine for the mild hyperthermia-controlled delivery of VEGF. Acta. Biomater. 2016, 40, 235-42.
150. Li, X.; Qu, K.; Zhou, B.; et al. Electrical stimulation of neonatal rat cardiomyocytes using conductive polydopamine-reduced graphene oxide-hybrid hydrogels for constructing cardiac microtissues. Colloid. Surface. B. 2021, 205, 111844.
151. Chen, R. R.; Silva, E. A.; Yuen, W. W.; Mooney, D. J. Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Pharm. Res. 2006, 24, 258-64.
152. Dai, F.; Zhang, J.; Chen, F.; et al. A multi‐responsive hydrogel combined with mild heat stimulation promotes diabetic wound healing by regulating inflammatory and enhancing angiogenesis. Adv. Sci. 2024, 11, 2408783.
153. Darge, H. F.; Andrgie, A. T.; Hanurry, E. Y.; et al. Localized controlled release of bevacizumab and doxorubicin by thermo-sensitive hydrogel for normalization of tumor vasculature and to enhance the efficacy of chemotherapy. Int. J. Pharm. 2019, 572, 118799.
154. Jiang, L.; Yang, X.; Zhang, Y.; et al. Novel ROS-scavenging hydrogel with enhanced anti-inflammation and angiogenic properties for promoting diabetic wound healing. Biomater. Adv. 2023, 144, 213226.
155. Tao, S.; Guo, S.; Li, M.; Ke, Q.; Guo, Y.; Zhang, C. Chitosan wound dressings incorporating exosomes derived from MicroRNA-126-overexpressing synovium mesenchymal stem cells provide sustained release of exosomes and heal full-thickness skin defects in a diabetic rat model. Stem. Cells. Transl. Med. 2017, 6, 736-47.
156. Li, H.; Feng, Y.; Zheng, X.; et al. M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization. J. Controlled. Release. 2022, 341, 16-30.
157. Zhang, K.; Zhao, X.; Chen, X.; et al. Enhanced therapeutic effects of mesenchymal stem cell-derived exosomes with an injectable hydrogel for hindlimb ischemia treatment. ACS. Appl. Mater. Interfaces. 2018, 10, 30081-91.
158. Li, M.; Wang, T.; Tian, H.; Wei, G.; Zhao, L.; Shi, Y. Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model. Artif. Cells. Nanomed. Biotechnol. 2019, 47, 3793-803.
159. Yi, H.; Chang, J. Y.; Shong, M. The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases. J. Mol. Endocrinol. 2018, 61, R91-R105.
160. Nomura, J.; So, A.; Tamura, M.; Busso, N. Intracellular ATP decrease mediates NLRP3 inflammasome activation upon nigericin and crystal stimulation. J. Immunol. 2015, 195, 5718-24.
161. Marín V, Buccini DF, Arboleda V JW, Cardoso MH, Franco OL. Expanding therapeutic strategies for intracellular bacterial infections through conjugates of apoptotic body-antimicrobial peptides. Drug. Discov. Today. 2023, 28, 103444.
162. Ryall, J. G.; Cliff, T.; Dalton, S.; Sartorelli, V. Metabolic reprogramming of stem cell epigenetics. Cell. Stem. Cell. 2015, 17, 651-62.
163. Wang, Z.; Zhao, F.; Xu, C.; et al. Metabolic reprogramming in skin wound healing. Burns. Trauma. 2024, 12, tkad047.
164. Ke, J.; Ding, J.; Xu, Y.; et al. Engineering microglial exosome-mediated microRNA-124-3p delivery for Alzheimer's disease combinational therapy. Biomater. Sci. 2026, 14, 186-97.
165. An, H.; Jang, Y.; Choi, J.; Hur, J.; Kim, S.; Kwon, Y. New Insights into AMPK, as a potential therapeutic target in metabolic dysfunction-associated steatotic liver disease and hepatic fibrosis. Biomol. Ther. 2024, 33, 18-38.
166. Gao, Y.; Yuan, Z.; Yuan, X.; et al. Bioinspired porous microspheres for sustained hypoxic exosomes release and vascularized bone regeneration. Bioact. Mater. 2022, 14, 377-88.
167. Edwards, N.; Feliers, D.; Zhao, Q.; Stone, R.; Christy, R.; Cheng, X. An electrochemically deposited collagen wound matrix combined with adipose-derived stem cells improves cutaneous wound healing in a mouse model of type 2 diabetes. J. Biomater. Appl. 2018, 33, 553-65.
168. Zhang, Y.; Chen, H.; Li, J. Recent advances on gelatin methacrylate hydrogels with controlled microstructures for tissue engineering. Int. J. Biol. Macromol. 2022, 221, 91-107.
169. Mauri, E.; Sacchetti, A.; Rossi, F. The synthesis of RGD-functionalized hydrogels as a tool for therapeutic applications. J. Vis. Exp. 2016, 54445.
170. Mo, Y.; Guo, R.; Zhang, Y.; Xue, W.; Cheng, B.; Zhang, Y. Controlled dual delivery of angiogenin and curcumin by electrospun nanofibers for skin regeneration. Tissue. Eng. Part. A. 2017, 23, 597-608.
171. Wei, Z.; Ren, J.; Hu, J.; Wei, H. Polyethylene glycol-polyester based temperature-sensitive hydrogel delivering mesenchymal stem cell-derived exosomes enhances acute skin wound healing. Front. Bioeng. Biotechnol. 2025, 13, 1730631.
172. Shi, Y.; Wang, S.; Wang, K.; et al. Relieving macrophage dysfunction by inhibiting SREBP2 activity: a hypoxic mesenchymal stem cells‐derived exosomes loaded multifunctional hydrogel for accelerated diabetic wound healing. Small 2024, 20, 2309276.
173. Govender, M.; Indermun, S.; Choonara, Y. E. 3D bioprinted microneedles: merging drug delivery and scaffold science for tissue-specific applications. Expert. Opin. Drug. Deliv. 2024, 21, 1559-72.
174. Britton, D.; Almanzar, D.; Xiao, Y.; et al. Exosome loaded protein hydrogel for enhanced gelation kinetics and wound healing. ACS. Appl. Bio. Mater. 2024, 7, 5992-6000.
175. Cho, B. S.; Kim, J. O.; Ha, D. H.; Yi, Y. W. Exosomes derived from human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis. Stem. Cell. Res. Ther. 2018, 9, 187.
176. Sun, X.; Ding, H.; Li, X.; Wu, Y.; Huang, X. Disulfiram-loaded nanovesicles hydrogel promotes healing of diabetic wound. J. Transl. Med. 2024, 22, 1066.
177. Wang, K.; Dong, R.; Tang, J.; et al. Exosomes laden self-healing injectable hydrogel enhances diabetic wound healing via regulating macrophage polarization to accelerate angiogenesis. Chem. Eng. J. 2022, 430, 132664.
178. Li, X.; Qu, S.; Ouyang, Q.; et al. A multifunctional composite nanoparticle with antibacterial activities, anti-inflammatory, and angiogenesis for diabetic wound healing. Int. J. Biol. Macromol. 2024, 260, 129531.
179. Lv, Y.; Li, L.; Zhang, J.; et al. Visible-light cross-linkable multifunctional hydrogels loaded with exosomes facilitate full-thickness skin defect wound healing through participating in the entire healing process. ACS. Appl. Mater. Interfaces. 2024, 16, 25923-37.
180. Xiong, Y.; Chen, L.; Liu, P.; et al. All-in-one: multifunctional hydrogel accelerates oxidative diabetic wound healing through timed‐release of exosome and fibroblast growth factor. Small 2021, 18, 2104229.
181. Shi, Q.; Qian, Z.; Liu, D.; et al. GMSC-derived exosomes combined with a chitosan/silk hydrogel sponge accelerates wound healing in a diabetic rat skin defect model. Front. Physiol. 2017, 8, 904.
182. Feng, J.; Yao, Y.; Wang, Q.; et al. Exosomes: potential key players towards novel therapeutic options in diabetic wounds. Biomed. Pharmacother. 2023, 166, 115297.
183. Geng, X.; Qi, Y.; Liu, X.; Shi, Y.; Li, H.; Zhao, L. A multifunctional antibacterial and self-healing hydrogel laden with bone marrow mesenchymal stem cell-derived exosomes for accelerating diabetic wound healing. Biomater. Adv. 2022, 133, 112613.
184. Jing, Y.; Huang, T.; Zhao, B.; et al. A ROS/glucose stimulated-responsive ADSCs-derived exosomes-release hydrogel system for diabetic wound healing. Chem. Eng. J. 2024, 487, 150561.
185. You, C.; Li, Q.; Wang, X.; et al. Silver nanoparticle loaded collagen/chitosan scaffolds promote wound healing via regulating fibroblast migration and macrophage activation. Sci. Rep. 2017, 7, 10489.
186. Hu, X.; Zhang, H.; Wang, Y.; et al. Synergistic antibacterial strategy based on photodynamic therapy: progress and perspectives. Chem. Eng. J. 2022, 450, 138129.
187. Losi, P.; Briganti, E.; Errico, C.; et al. Fibrin-based scaffold incorporating VEGF- and bFGF-loaded nanoparticles stimulates wound healing in diabetic mice. Acta. Biomater. 2013, 9, 7814-21.
188. Shafei, S.; Khanmohammadi, M.; Heidari, R.; et al. Exosome loaded alginate hydrogel promotes tissue regeneration in full‐thickness skin wounds: an in vivo study. J. Biomed. . Mater. Res. 2019, 108, 545-56.
189. Zhou, L.; Jiao, X.; Liu, S.; et al. Functional DNA-based hydrogel intelligent materials for biomedical applications. J. Mater. Chem. B. 2020, 8, 1991-2009.
190. Khoshnoudi, P.; Sabiza, S.; Khosravi, M.; Mohamadian, B. Exploring effect of M2 macrophages on experimental full‐thickness wound healing in streptozotocin‐induced diabetic rats. Int. J. Exp. Pathol. 2023, 105, 13-20.
191. Tu, Z.; Chen, M.; Wang, M.; et al. Engineering bioactive M2 macrophage-polarized anti-inflammatory, antioxidant, and antibacterial scaffolds for rapid angiogenesis and diabetic wound repair. Adv. Funct. Mater. 2021, 31, 2100924.
192. Hu, Y.; Ruan, X.; Lv, X.; et al. Biofilm microenvironment-responsive nanoparticles for the treatment of bacterial infection. Nano. Today. 2022, 46, 101602.
193. Schwarz, G.; Ren, X.; Xie, W.; Guo, H.; Jiang, Y.; Zhang, J. Engineered exosomes: a promising drug delivery platform with therapeutic potential. Front. Mol. Biosci. 2025, 12, 1583992.
194. Zhang, L.; Li, T.; Yu, Y.; et al. An injectable conductive hydrogel restores electrical transmission at myocardial infarct site to preserve cardiac function and enhance repair. Bioact. Mater. 2023, 20, 339-54.
195. Yan, C.; Wang, X.; Wang, Q.; et al. A novel conductive polypyrrole-chitosan hydrogel containing human endometrial mesenchymal stem cell-derived exosomes facilitated sustained release for cardiac repair. Adv. Healthcare. Mater. 2024, 13, 2304207.
196. Yaping, X.; Guotian, Y.; Dandan, J.; Jintao, D.; Xinyi, L.; Zhikun, G. Fibroblast-derived exosomal miRNA-133 promotes cardiomyocyte-like differentiation. Acta. Histochem. 2022, 124, 151931.
197. Chen, C.; Cai, S.; Wu, M.; et al. Role of cardiomyocyte-derived exosomal MicroRNA-146a-5p in macrophage polarization and activation. Dis. Markers. 2022, 2022, 1-13.
198. Ben-Mordechai, T.; Holbova, R.; Landa-Rouben, N.; et al. Macrophage subpopulations are essential for infarct repair with and without stem cell therapy. J. Am. Coll. Cardiol. 2013, 62, 1890-901.
199. Li, S.; Yue, Y.; Xu, W.; Xiong, S. MicroRNA-146a represses mycobacteria-induced inflammatory response and facilitates bacterial replication via targeting IRAK-1 and TRAF-6. PLoS. ONE. 2013, 8, e81438.
200. Wang, M.; Wang, C.; Chen, M.; et al. Efficient angiogenesis-based diabetic wound healing/skin reconstruction through bioactive antibacterial adhesive ultraviolet shielding nanodressing with exosome release. ACS. Nano. 2019, 13, 10279-93.
201. Elzamly, S.; Agina, H. A.; Elbalshy, A. E.; Abuhashim, M.; Saad, E.; Abd, Elmageed. Z. Y. Integration of VEGF and α-SMA expression improves the prediction accuracy of fibrosis in chronic hepatitis C liver biopsy. Appl. Immunohistochem. Mol. Morphol. 2017, 25, 261-70.
202. Chen, J.; Chen, H.; Li, P.; et al. Simultaneous regeneration of articular cartilage and subchondral bone in vivo using MSCs induced by a spatially controlled gene delivery system in bilayered integrated scaffolds. Biomaterials 2011, 32, 4793-805.
203. Sun, T.; Feng, Z.; He, W.; et al. Novel 3D-printing bilayer GelMA-based hydrogel containing BP, β-TCP and exosomes for cartilage-bone integrated repair. Biofabrication 2023, 16, 015008.
204. Wang, Y.; Wang, J.; Gao, R.; et al. Biomimetic glycopeptide hydrogel coated PCL/nHA scaffold for enhanced cranial bone regeneration via macrophage M2 polarization-induced osteo-immunomodulation. Biomaterials 2022, 285, 121538.
205. Battaglia, M.; Rimondi, E.; Monti, C.; et al. Validity of T2 mapping in characterization of the regeneration tissue by bone marrow derived cell transplantation in osteochondral lesions of the ankle. Eur. J. Radiol. 2011, 80, e132-9.
206. Levingstone, T. J.; Thompson, E.; Matsiko, A.; Schepens, A.; Gleeson, J. P.; O’brien, F. J. Multi-layered collagen-based scaffolds for osteochondral defect repair in rabbits. Acta. Biomater. 2016, 32, 149-60.
207. Xu, J.; Ji, J.; Jiao, J.; et al. 3D printing for bone-cartilage interface regeneration. Front. Bioeng. Biotechnol. 2022, 10, 828921.
208. Ma, T.; Xu, G.; Gao, T.; et al. Engineered exosomes with ATF5-modified mRNA loaded in injectable thermogels alleviate osteoarthritis by targeting the mitochondrial unfolded protein response. ACS. Appl. Mater. Interfaces. 2024, 16, 21383-99.
209. Liu, Y.; Lin, S.; Xu, Z.; et al. High‐performance hydrogel-encapsulated engineered exosomes for supporting endoplasmic reticulum homeostasis and boosting diabetic bone regeneration. Adv. Sci. 2024, 11, 2309491.
210. Xu, H.; Feng, J.; Dai, N.; et al. Self-assembling peptide hydrogel scaffold integrating stem cell-derived exosomes for infected bone defects. J. Biomater. Sci. Polym. Ed. 2024, 35, 1511-22.
211. Lotz, M. K.; Caramés, B. Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA. Nat. Rev. Rheumatol. 2011, 7, 579-87.
212. Contreras-naranjo, J. C.; Wu, H.; Ugaz, V. M. Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine. Lab. Chip. 2017, 17, 3558-77.
213. Biswas, A. A.; Dhondale, M. R.; Agrawal, A. K.; Serrano, D. R.; Mishra, B.; Kumar, D. Advancements in microneedle fabrication techniques: artificial intelligence assisted 3D-printing technology. Drug. Deliv. Transl. Res. 2024, 14, 1458-79.
214. Jangam, T. C.; Desai, S. A.; Patel, V. P.; Pagare, N. B.; Raut, N. D. Exosomes as therapeutic and diagnostic tools: advances, challenges, and future directions. Cell. Biochem. Biophys. 2025, 83, 2805-29.
215. Batrakova, E. V.; Kim, M. S. Development and regulation of exosome‐based therapy products. WIREs. Nanomed. Nanobiotechnol. 2016, 8, 744-57.
216. Verma, N.; Arora, S. Navigating the global regulatory landscape for exosome-based therapeutics: challenges, strategies, and future directions. Pharmaceutics 2025, 17, 990.
