REFERENCES
1. Zhao, Y.; Liu, S.; Shi, Z.; Zhu, H.; Li, M.; Yu, Q. Pathogen infection-responsive nanoplatform targeting macrophage endoplasmic reticulum for treating life-threatening systemic infection. Nano. Res. 2022, 15, 6243-55.
2. Guo, Z.; Chen, Y.; Wang, Y.; Jiang, H.; Wang, X. Advances and challenges in metallic nanomaterial synthesis and antibacterial applications. J. Mater. Chem. B. 2020, 8, 4764-77.
4. Hou, J.; Long, X.; Wang, X.; et al. Global trend of antimicrobial resistance in common bacterial pathogens in response to antibiotic consumption. J. Hazard. Mater. 2023, 442, 130042.
5. Zhou, Z.; Li, B.; Liu, X.; et al. Recent progress in photocatalytic antibacterial. ACS. Appl. Bio. Mater. 2021, 4, 3909-36.
6. Rappuoli, R.; Bloom, D. E.; Black, S. Deploy vaccines to fight superbugs. Nature 2017, 552, 165-7.
7. Lemire, J. A.; Harrison, J. J.; Turner, R. J. Antimicrobial activity of metals: mechanisms, molecular targets and applications. Nat. Rev. Microbiol. 2013, 11, 371-84.
8. Lucky, S. S.; Soo, K. C.; Zhang, Y. Nanoparticles in photodynamic therapy. Chem. Rev. 2015, 115, 1990-2042.
9. Yang, Z.; Liu, Z. W.; Allaker, R. P.; et al. A review of nanoparticle functionality and toxicity on the central nervous system. J. R. Soc. Interface. 2010, 7 Suppl 4, S411-22.
10. Wang, T. Y.; Zhu, X. Y.; Wu, F. G. Antibacterial gas therapy: Strategies, advances, and prospects. Bioact. Mater. 2023, 23, 129-55.
11. Alves, S. R.; Calori, I. R.; Tedesco, A. C. Photosensitizer-based metal-organic frameworks for highly effective photodynamic therapy. Mater. Sci. Eng. C. Mater. Biol. Appl. 2021, 131, 112514.
12. Saxena, V.; Sadoqi, M.; Shao, J. Degradation kinetics of indocyanine green in aqueous solution. J. Pharm. Sci. 2003, 92, 2090-7.
13. Quek, J.; Uroro, E.; Goswami, N.; Vasilev, K. Design principles for bacteria-responsive antimicrobial nanomaterials. Mater. Today. Chem. 2022, 23, 100606.
14. Hall-Stoodley, L.; Costerton, J. W.; Stoodley, P. Bacterial biofilms: from the natural environment to infectious diseases. Nat. Rev. Microbiol. 2004, 2, 95-108.
15. Townsley, L.; Shank, E. A. Natural-product antibiotics: cues for modulating bacterial biofilm formation. Trends. Microbiol. 2017, 25, 1016-26.
16. Yan, L.; Gopal, A.; Kashif, S.; et al. Metal organic frameworks for antibacterial applications. Chem. Eng. J. 2022, 435, 134975.
17. Lu, X.; Ye, J.; Zhang, D.; et al. Silver carboxylate metal-organic frameworks with highly antibacterial activity and biocompatibility. J. Inorg. Biochem. 2014, 138, 114-21.
18. Wei, Y.; Chen, C.; Zhai, S.; et al. Enrofloxacin/florfenicol loaded cyclodextrin metal-organic-framework for drug delivery and controlled release. Drug. Delivery. 2021, 28, 372-9.
19. Wang, H.; Wu, Y.; Wang, Y.; Zou, H.; Wang, H.; Zhou, M. Vancomycin-loaded porphyrinic MOF nanoparticles for killing pathogenic bacteria. ACS. Appl. Nano. Mater. 2023, 6, 9874-83.
20. Soltani, B.; Nabipour, H.; Nasab, N. A. Efficient storage of gentamicin in nanoscale zeolitic imidazolate framework-8 nanocarrier for pH-responsive drug release. J. Inorg. Organomet. Polym. Mater. 2017, 28, 1090-7.
21. Amer, T. A. M.; Palanisamy, S.; So, P. B.; et al. Sustained releasable copper and zinc biogenic ions Co-assembled in metal-organic frameworks reinforced bacterial eradication and wound mitigation in diabetic mice. Bioconjugate. Chem. 2023, 34, 1688-703.
22. Duan, F.; Feng, X.; Jin, Y.; et al. Metal-carbenicillin framework-based nanoantibiotics with enhanced penetration and highly efficient inhibition of MRSA. Biomaterials 2017, 144, 155-65.
23. Chen, M.; Long, Z.; Dong, R.; et al. Titanium incorporation into Zr-porphyrinic metal-organic frameworks with enhanced antibacterial activity against multidrug-resistant pathogens. Small 2020, 16, e1906240.
24. Acharya, A. P.; Sezginel, K. B.; Gideon, H. P.; et al. In silico identification and synthesis of a multi-drug loaded MOF for treating tuberculosis. J. Control. Release. 2022, 352, 242-55.
25. Redfern, J.; Geerts, L.; Seo, J. W.; Verran, J.; Tosheva, L.; Wee, L. H. Toxicity and antimicrobial properties of ZnO@ZIF-8 embedded silicone against planktonic and biofilm catheter-associated pathogens. ACS. Appl. Nano. Mater. 2018, 1, 1657-65.
26. Yi, J.; Pei, C.; Zhang, T.; et al. Nanoscale multipatterning Zn,Co-ZIF@FeOOH for eradication of multidrug-resistant bacteria and antibacterial treatment of wounds. ACS. Appl. Mater. Interfaces. 2024, 16, 58217-25.
27. Li, H.; Li, B.; Lv, D.; Li, W.; Lu, Y.; Luo, G. Biomaterials releasing drug responsively to promote wound healing via regulation of pathological microenvironment. Adv. Drug. Delivery. Rev. 2023, 196, 114778.
28. Xiang, Y. L.; Tang, D. Y.; Yan, L. L.; et al. Poly-l-lysine modified MOF nanoparticles with pH/ROS sensitive CIP release and CUR triggered photodynamic therapy against drug-resistant bacterial infection. Int. J. Biol. Macromol. 2024, 266, 131330.
29. Zhang, Y.; Sun, P.; Zhang, L.; et al. Silver-infused porphyrinic metal-organic framework: surface-adaptive, on-demand nanoplatform for synergistic bacteria killing and wound disinfection. Adv. Funct. Mater. 2019, 29, 1808594.
30. Ding, N.; Qin, M.; Sun, Y.; et al. Universal near-infrared fluorescent nanoprobes for detection and real-time imaging of ATP in real food samples, living cells, and bacteria. J. Agric. Food. Chem. 2023, 71, 12070-9.
31. Qiao, E.; Qiu, F.; Guo, X.; et al. Biomaterial-mediated modulation of tumor microenvironment and therapeutic sensitization. EngMedicine 2025, 2, 100092.
32. Sobotta, L.; Skupin-Mrugalska, P.; Piskorz, J.; Mielcarek, J. Porphyrinoid photosensitizers mediated photodynamic inactivation against bacteria. Eur. J. Med. Chem. 2019, 175, 72-106.
33. Tian, J.; Huang, B.; Nawaz, M. H.; Zhang, W. Recent advances of multi-dimensional porphyrin-based functional materials in photodynamic therapy. Coord. Chem. Rev. 2020, 420, 213410.
34. Sies, H.; Belousov, V. V.; Chandel, N. S.; et al. Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology. Nat. Rev. Mol. Cell. Biol. 2022, 23, 499-515.
35. Lan, G.; Ni, K.; Lin, W. Nanoscale metal-organic frameworks for phototherapy of cancer. Coord. Chem. Rev. 2019, 379, 65-81.
36. Zhou, Z.; Song, J.; Nie, L.; Chen, X. Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy. Chem. Soc. Rev. 2016, 45, 6597-626.
37. Sun, J.; Song, L.; Fan, Y.; et al. Synergistic photodynamic and photothermal antibacterial nanocomposite membrane triggered by single NIR light source. ACS. Appl. Mater. Interfaces. 2019, 11, 26581-9.
38. Agostinis, P.; Berg, K.; Cengel, K. A.; et al. Photodynamic therapy of cancer: an update. CA. Cancer. J. Clin. 2011, 61, 250-81.
39. Chen, Y.; Gao, Y.; Chen, Y.; Liu, L.; Mo, A.; Peng, Q. Nanomaterials-based photothermal therapy and its potentials in antibacterial treatment. J. Control. Release. 2020, 328, 251-62.
40. Du, J.; Jia, T.; Zhang, J.; Chen, G. Heterostructures combining upconversion nanoparticles and metal-organic framework: fundamental, classification, and theranostic applications. Adv. Opt. Mater. 2023, 11, 2202122.
41. Tan, C.; Li, X.; Li, Z.; et al. Near-infrared-responsive nanoplatforms integrating dye-sensitized upconversion and heavy-atom effect for enhanced photodynamic therapy efficacy. Nano. Today. 2024, 54, 102089.
42. Huang, J.; Feng, X.; Zhao, Y.; et al. Coral-like AgNPs hybrided MOFs modulated with biopolymer polydopamine for synergistic antibacterial and biofilm eradication. Int. J. Biol. Macromol. 2024, 282, 137080.
43. Huo, J.; Jia, Q.; Huang, H.; et al. Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections. Chem. Soc. Rev. 2021, 50, 8762-89.
44. Yang, Q.; Zhao, J.; Muhammad, A.; et al. Biopolymer coating for particle surface engineering and their biomedical applications. Mater. Today. Bio. 2022, 16, 100407.
45. Li, H.; Yin, D.; Li, W.; Tang, Q.; Zou, L.; Peng, Q. Polydopamine-based nanomaterials and their potentials in advanced drug delivery and therapy. Colloids. Surf. B. Biointerfaces. 2021, 199, 111502.
46. Jin, A.; Wang, Y.; Lin, K.; Jiang, L. Nanoparticles modified by polydopamine: working as "drug" carriers. Bioact. Mater. 2020, 5, 522-41.
47. He, Y.; Wang, X.; Zhang, C.; Sun, J.; Xu, J.; Li, D. Near-infrared light-mediated cyclodextrin metal-organic frameworks for synergistic antibacterial and anti-biofilm therapies. Small 2023, 19, e2300199.
48. Fang, L.; Chen, Y.; Shan, W.; et al. HKUST-1 loaded few-layer Ti3C2Tx for synergistic chemo-photothermal effects to enhance antibacterial activity. J. Mater. Chem. B. 2023, 11, 3929-40.
49. Pan, X.; Wang, W.; Huang, Z.; et al. MOF-derived double-layer hollow nanoparticles with oxygen generation ability for multimodal imaging-guided sonodynamic therapy. Angew. Chem. Int. Ed. 2020, 59, 13557-61.
50. Son, S.; Kim, J. H.; Wang, X.; et al. Multifunctional sonosensitizers in sonodynamic cancer therapy. Chem. Soc. Rev. 2020, 49, 3244-61.
51. Wang, R.; Liu, Q.; Gao, A.; et al. Recent developments of sonodynamic therapy in antibacterial application. Nanoscale 2022, 14, 12999-3017.
52. Xiao, Z.; Chen, Q.; Yang, Y.; et al. State of the art advancements in sonodynamic therapy (SDT): metal-Organic frameworks for SDT. Chem. Eng. J. 2022, 449, 137889.
53. Zhang, H.; Shi, R.; Xie, A.; et al. Novel TiO2/PEGDA hybrid hydrogel prepared in situ on tumor cells for effective photodynamic therapy. ACS. Appl. Mater. Interfaces. 2013, 5, 12317-22.
54. Zhou, Y.; Wang, M.; Dai, Z. The molecular design of and challenges relating to sensitizers for cancer sonodynamic therapy. Mater. Chem. Front. 2020, 4, 2223-34.
55. Ouyang, J.; Tang, Z.; Farokhzad, N.; et al. Ultrasound mediated therapy: recent progress and challenges in nanoscience. Nano. Today. 2020, 35, 100949.
56. Geng, X.; Chen, Y.; Chen, Z.; Wei, X.; Dai, Y.; Yuan, Z. Oxygen-carrying biomimetic nanoplatform for sonodynamic killing of bacteria and treatment of infection diseases. Ultrason. Sonochem. 2022, 84, 105972.
57. Wang, H.; Mu, N.; He, Y.; et al. Ultrasound-controlled MXene-based Schottky heterojunction improves anti-infection and osteogenesis properties. Theranostics 2023, 13, 1669-83.
58. Fu, C.; Zhou, H.; Tan, L.; et al. Microwave-activated Mn-doped zirconium metal-organic framework nanocubes for highly effective combination of microwave dynamic and thermal therapies against cancer. ACS. Nano. 2018, 12, 2201-10.
59. Majdzadeh-Ardakani, K.; Banaszak, Holl. M. M. Nanostructured materials for microwave receptors. Prog. Mater. Sci. 2017, 87, 221-45.
60. Du, Y.; Zhou, J.; He, F.; et al. A bright future: advanced nanotechnology-assisted microwave therapy. Nano. Today. 2023, 52, 101963.
61. Qiao, Y.; Wu, S.; Zheng, Y.; et al. Enhancing microwave dynamic effects via surface states of ultrasmall 2D MOF triggered by interface confinement for antibiotics-free therapy. Adv. Sci. 2023, 10, e2300084.
62. Wu, Q.; Xia, N.; Long, D.; et al. Dual-functional supernanoparticles with microwave dynamic therapy and microwave thermal therapy. Nano. Lett. 2019, 19, 5277-86.
63. Zheng, Q.; Liu, X.; Mao, C.; et al. Tribovoltaic effect strengthened microwave catalytic antibacterial composite hydrogel. Adv. Healthc. Mater. 2024, 13, e2402266.
64. Wei, S.; Qiao, Y.; Wu, Z.; et al. Na+ inserted metal-organic framework for rapid therapy of bacteria-infected osteomyelitis through microwave strengthened Fenton reaction and thermal effects. Nano. Today. 2021, 37, 101090.
65. Tan, L.; Li, J.; Liu, X.; et al. Rapid biofilm eradication on bone implants using red phosphorus and near-infrared light. Adv. Mater. 2018, 30, e1801808.
66. Ke, Q.; Jiang, K.; Li, H.; Zhang, L.; Chen, B. Hierarchically micro-, meso-, and macro-porous MOF Nanosystems for localized cross-scale dual-biomolecule loading and guest-carrier cooperative anticancer therapy. ACS. Nano. 2024, 18, 21911-24.
67. Wang, J.; Li, L.; Hu, X.; Zhou, L.; Hu, J. pH-responsive on-demand release of eugenol from metal-organic frameworks for synergistic bacterial killing. Dalton. Trans. 2024, 53, 2826-32.
68. Deng, J.; Wang, K.; Wang, M.; Yu, P.; Mao, L. Mitochondria targeted nanoscale zeolitic imidazole framework-90 for ATP imaging in live cells. J. Am. Chem. Soc. 2017, 139, 5877-82.
69. Jiang, Z.; Wang, Y.; Sun, L.; et al. Dual ATP and pH responsive ZIF-90 nanosystem with favorable biocompatibility and facile post-modification improves therapeutic outcomes of triple negative breast cancer in vivo. Biomaterials 2019, 197, 41-50.
70. Ding, N.; Zhang, B.; Khan, I. M.; et al. Dual pH- and ATP-responsive antibacterial nanospray: on-demand release of antibacterial factors, imaging monitoring, and accelerated healing of bacteria-infected wounds under NIR activation. ACS. Appl. Mater. Interfaces. 2024, 16, 30728-41.
71. Fulaz, S.; Vitale, S.; Quinn, L.; Casey, E. Nanoparticle-biofilm interactions: the role of the EPS matrix. Trends. Microbiol. 2019, 27, 915-26.
72. Flemming, H. C.; Wuertz, S. Bacteria and archaea on Earth and their abundance in biofilms. Nat. Rev. Microbiol. 2019, 17, 247-60.
73. Skvortsova, A.; Kocianova, A.; Guselnikova, O.; et al. Self-activated antibacterial MOF-based coating on medically relevant polypropylene. Appl. Surf. Sci. 2023, 623, 157048.
74. Guo, W.; Wang, Y.; Zhang, K.; et al. Near-infrared light-propelled MOF@Au nanomotors for enhanced penetration and sonodynamic therapy of bacterial biofilms. Chem. Mater. 2023, 35, 6853-64.
75. Hu, H.; Kang, X.; Shan, Z.; et al. A DNase-mimetic artificial enzyme for the eradication of drug-resistant bacterial biofilm infections. Nanoscale 2022, 14, 2676-85.
76. Chen, Z.; Ji, H.; Liu, C.; Bing, W.; Wang, Z.; Qu, X. A multinuclear metal complex based DNase-mimetic artificial enzyme: matrix cleavage for combating bacterial biofilms. Angew. Chem. 2016, 128, 10890-4.
77. Gokhale, K. M.; Patravale, V.; Pingale, R.; Pandey, P.; Vavilala, S. L. Se-functionalized ZIF-8 nanoparticles: synthesis, characterization and disruption of biofilms and quorum sensing inSerratia marcescens. Biomed. Mater. 2024, 19, 055020.
78. Jia, D.; Zou, Y.; Zhang, Y.; et al. A self-supplied hydrogen peroxide and nitric oxide-generating nanoplatform enhances the efficacy of chemodynamic therapy for biofilm eradication. J. Colloid. Interface. Sci. 2025, 678, 20-9.
79. Ye, J.; Fan, Y.; Niu, G.; Zhou, B.; Kang, Y.; Ji, X. Intelligent micro/nanomotors: fabrication, propulsion, and biomedical applications. Nano. Today. 2024, 55, 102212.
80. Yang, C.; Luo, Y.; Shen, H.; et al. Inorganic nanosheets facilitate humoral immunity against medical implant infections by modulating immune co-stimulatory pathways. Nat. Commun. 2022, 13, 4866.
81. Hu, X.; Ma, R.; Zhang, P.; et al. Biomimetic metal-organic framework combats biofilm-associated infections via hyperthermia-enhanced bacterial metabolic interference and autophagy-promoted adaptive immunity. Adv. Funct. Mater. 2023, 34, 2310509.
82. Thurlow, L. R.; Hanke, M. L.; Fritz, T.; et al. Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivo. J. Immunol. 2011, 186, 6585-96.
83. Arciola, C. R.; Campoccia, D.; Montanaro, L. Implant infections: adhesion, biofilm formation and immune evasion. Nat. Rev. Microbiol. 2018, 16, 397-409.
84. Su, Z.; Kong, L.; Mei, J.; et al. Enzymatic bionanocatalysts for combating peri-implant biofilm infections by specific heat-amplified chemodynamic therapy and innate immunomodulation. Drug. Resist. Updat. 2023, 67, 100917.
85. Luo, Z.; Lu, R.; Shi, T.; et al. Enhanced bacterial cuproptosis-like death via reversal of hypoxia microenvironment for biofilm infection treatment. Adv. Sci. 2024, 11, e2308850.
86. Wolfson, S. J.; Hitchings, R.; Peregrina, K.; et al. Bacterial hydrogen sulfide drives cryptic redox chemistry in gut microbial communities. Nat. Metab. 2022, 4, 1260-70.
87. Yang, Y.; Huang, K.; Yuan, K.; et al. A novel antibacterial immune activator: Bi-MOF acts as H2S scavenger to suppress HIF-1α S-sulfhydration and alleviate implant-associated infection. Nano. Today. 2024, 57, 102334.
88. Barayeu, U.; Schilling, D.; Eid, M.; et al. Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals. Nat. Chem. Biol. 2023, 19, 28-37.
89. Lewis, M. L.; Surewaard, B. G. J. Neutrophil evasion strategies by Streptococcus pneumoniae and Staphylococcus aureus. Cell. Tissue. Res. 2018, 371, 489-503.
90. Ge, M.; Zhu, W.; Mei, J.; et al. Piezoelectric-enhanced nanocatalysts trigger neutrophil N1 polarization against bacterial biofilm by disrupting redox homeostasis. Adv. Mater. 2025, 37, e2409633.
91. Si, Y.; Liu, H.; Yu, H.; Jiang, X.; Sun, D. MOF-derived CuO@ZnO modified titanium implant for synergistic antibacterial ability, osteogenesis and angiogenesis. Colloids. Surf. B. Biointerfaces. 2022, 219, 112840.
92. Shen, X.; Zhang, Y.; Ma, P.; et al. Fabrication of magnesium/zinc-metal organic framework on titanium implants to inhibit bacterial infection and promote bone regeneration. Biomaterials 2019, 212, 1-16.
93. Chen, X. B.; Li, Y. C.; Hodgson, P. D.; Wen, C. The importance of particle size in porous titanium and nonporous counterparts for surface energy and its impact on apatite formation. Acta. Biomater. 2009, 5, 2290-302.
94. Chen, J.; Zhang, X.; Huang, C.; et al. Osteogenic activity and antibacterial effect of porous titanium modified with metal-organic framework films. J. Biomed. Mater. Res. A. 2017, 105, 834-46.
95. Wen, X.; Liu, Y.; Xi, F.; Zhang, X.; Kang, Y. Micro-arc oxidation (MAO) and its potential for improving the performance of titanium implants in biomedical applications. Front. Bioeng. Biotechnol. 2023, 11, 1282590.
96. Teng, W.; Zhang, Z.; Wang, Y.; et al. Iodine immobilized metal-organic framework for NIR-triggered antibacterial therapy on orthopedic implants. Small 2021, 17, e2102315.
97. Si, Y.; Liu, H.; Li, M.; Jiang, X.; Yu, H.; Sun, D. An efficient metal-organic framework-based drug delivery platform for synergistic antibacterial activity and osteogenesis. J. Colloid. Interface. Sci. 2023, 640, 521-39.
98. Cheng, Y.; Yang, H.; Yang, Y.; et al. Progress in TiO2 nanotube coatings for biomedical applications: a review. J. Mater. Chem. B. 2018, 6, 1862-86.
99. Yu, Y.; Ran, Q.; Shen, X.; Zheng, H.; Cai, K. Enzyme responsive titanium substrates with antibacterial property and osteo/angio-genic differentiation potentials. Colloids. Surf. B. Biointerfaces. 2020, 185, 110592.
100. Wang, L.; Dai, F.; Yang, Y.; Zhang, Z. Zeolitic imidazolate framework-8 with encapsulated naringin synergistically improves antibacterial and osteogenic properties of Ti implants for osseointegration. ACS. Biomater. Sci. Eng. 2022, 8, 3797-809.
101. Zhao, X.; Chen, Z.; Zhang, S.; et al. Application of metal-organic frameworks in infectious wound healing. J. Nanobiotechnol. 2024, 22, 387.
102. Parizi, M. K.; Doll, K.; Rahim, M. I.; Mikolai, C.; Winkel, A.; Stiesch, M. Antibacterial and cytocompatible: combining silver nitrate with strontium acetate increases the therapeutic window. Int. J. Mol. Sci. 2022, 23, 8058.
103. Cecotto, L.; Stapels, D. A. C.; van, Kessel. K. P. M.; et al. Evaluation of silver bio-functionality in a multicellular in vitro model: towards reduced animal usage in implant-associated infection research. Front. Cell. Infect. Microbiol. 2023, 13, 1186936.
104. Zhu, T.; Ni, Q.; Wang, W.; et al. Cu-MOF-decorated 3D-printed scaffolds for infection control and bone regeneration. J. Funct. Biomater. 2025, 16, 83.
105. Desai, S. S.; Deepika, Roy. K. A.; Abishad, P.; et al. Harnessing in vitro cytotoxicity and antibacterial potential of a novel silver-DABCO framework against multi-drug-resistant pathogens. RSC. Adv. 2025, 15, 8180-8.
106. Yu, Z.; Lepoitevin, M.; Serre, C. Iron-MOFs for biomedical applications. Adv. Healthc. Mater. 2025, 14, e2402630.
107. Zhou, F.; Xu, Z.; Wang, Q.; et al. Nitric oxide-driven copper homeostasis and osteogenesis in cranial defect regeneration using l-arginine-loaded HKUST-1. Biomaterials 2026, 325, 123557.
108. Wu, M. X.; Yang, Y. W. Metal-organic framework (MOF)-based drug/cargo delivery and cancer therapy. Adv. Mater. 2017, 29, 1606134.
109. Ouyang, B.; Ouyang, P.; Shi, M.; et al. Low toxicity of metal-organic framework MOF-199 to bacteria Escherichia coli and Staphylococcus aureus. J. Hazard. Mater. Adv. 2021, 1, 100002.
110. Ettlinger, R.; Lächelt, U.; Gref, R.; et al. Toxicity of metal-organic framework nanoparticles: from essential analyses to potential applications. Chem. Soc. Rev. 2022, 51, 464-84.
111. Zhao, F.; Wan, X.; Liang, Y.; et al. Prospects, advances, and applications of BioMOF-based platforms. Top. Curr. Chem. 2025, 383, 34.
112. Luo, Z.; Ma, J.; Wang, Y.; et al. Application of Mg-MOF-loaded gelatin microspheres with osteogenic, angiogenic, and ROS scavenging capabilities in bone defect repair. Int. J. Biol. Macromol. 2024, 280, 135721.
113. Huang, L.; Guo, R.; Mao, Y.; Xu, Z.; Chi, Y. In situ encapsulation of capsaicinoids in MIL-88A as a food-grade nanopreservative for meat safety. Food. Chem. 2024, 460, 140738.
114. Sahiner, N.; Guven, O.; Demirci, S.; et al. Tannic acid-based bio-MOFs with antibacterial and antioxidant properties acquiring non-hemolytic and non-cytotoxic characteristics. Colloids. Surf. B. Biointerfaces. 2025, 252, 114669.
115. Si, Y.; Luo, H.; Zhang, P.; et al. CD-MOFs: from preparation to drug delivery and therapeutic application. Carbohydr. Polym. 2024, 323, 121424.
116. Hu, Z.; He, F.; Liu, A.; et al. Engineering a biocompatible chitosan/MOF aerogel for hyperbilirubinemia treatment in liver failure. J. Mater. Chem. B. 2025, 13, 11210-23.
117. Obaid, E. A. M. S.; Yu, C.; Ma, Y.; Yang, H.; Fu, Z. Exploring the efficacy of pH-responsive vancomycin/Ag/ZIF-8 nanoparticles modified with hyaluronic acid for enhanced antibacterial therapy and wound healing. ACS. Appl. Mater. Interfaces. 2024, 16, 65942-54.
118. Chakraborty, D.; Yurdusen, A.; Mouchaham, G.; Nouar, F.; Serre, C. Large-scale production of metal-organic frameworks. Adv. Funct. Mater. 2023, 34, 2309089.
119. Dai, Q.; Walkey, C.; Chan, W. C. Polyethylene glycol backfilling mitigates the negative impact of the protein corona on nanoparticle cell targeting. Angew. Chem. Int. Ed. 2014, 53, 5093-6.
