fig7

6-PPD quinone-inhibited retinoic acid synthesis mediates toxicity through feedback loop between ALH-3/DHS-19-SEX-1 axis and intestinal signals in <i>Caenorhabditis elegans</i>

Figure 7. Effect of treatment with retinoic acid (15 μM) on toxicity of 6-PPDQ (10 μg/L) in wild-type nematodes. (A) Effect of treatment with retinoic acid on 6-PPDQ toxicity in inducing ROS generation in wild-type nematodes; (B) Effect of treatment with retinoic acid on 6-PPDQ toxicity in decreasing locomotion in wild-type nematodes; (C) Effect of treatment with retinoic acid on 6-PPDQ toxicity in reducing brood size wild-type nematodes; (D) Effect of treatment with retinoic acid on sex-1 expression in 6-PPDQ-exposed nematodes. **P < 0.01. 6-PPDQ: N’-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine quinone; ROS: reactive oxygen species.

Journal of Environmental Exposure Assessment
ISSN 2771-5949 (Online)

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