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From: 6-PPD quinone-inhibited retinoic acid synthesis mediates toxicity through feedback loop between ALH-3/DHS-19-SEX-1 axis and intestinal signals in Caenorhabditis elegans

6-PPD quinone-inhibited retinoic acid synthesis mediates toxicity through feedback loop between ALH-3/DHS-19-SEX-1 axis and intestinal signals in <i>Caenorhabditis elegans</i>

Figure 3. Effect of intestinal RNAi of alh-3 and dhs-19 on 6-PPDQ toxicity. (A) Effect of intestinal RNAi of alh-3 and dhs-19 on 6-PPDQ toxicity in inducing ROS generation. ^**P < 0.01; (B) Effect of intestinal RNAi of alh-3 and dhs-19 on 6-PPDQ toxicity in reducing brood size. ^**P < 0.01; (C) Effect of intestinal RNAi of alh-3 and dhs-19 on retinoic acid content in 6-PPDQ-exposed nematodes. ^**P < 0.01 vs. VP303 (L4440). Exposure concentration of 6-PPDQ was 10 μg/L. RNA interference; 6-PPDQ: N’-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine quinone; ROS: reactive oxygen species.

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Committee on Publication Ethics

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Committee on Publication Ethics

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