fig5

Figure 5. Mediation analysis. (A) hsCRP as a mediator in the relationship between eGDR and incident stroke; (B) eGDR as a mediator in the relationship between hsCRP and incident stroke. Adjustment variables included: age, sex, education level, marital status, work status, disability, smoking, alcohol consumption, BMI, hyperlipidemia, DM, HD, lipid-lowering medication, glucose-lowering medication, and antihypertensive medication. Both eGDR and high-sensitivity C-reactive protein were dichotomized according to their median values. eGDR: Estimated glucose disposal rate; hsCRP: high-sensitivity C-reactive protein; BMI: body mass index; DM: diabetes mellitus; HD: heart disease. IE: indirect effect; DE: direct effect; TE: total effect