fig1

Figure 1. TFEB-mediated adaptation to hypertrophic stress. In response to hypertrophic stimuli, cardiomyocyte TFEB coordinates lysosomal and mitochondrial programs that contribute to limiting hypertrophic growth and preserving cardiac energetics and function. Dashed lines and question marks indicate potential mechanistic links between lysosomal function, AMPK signaling, mitochondrial homeostasis, and cardiac adaptation that remain unresolved and warrant further investigation. Created in BioRender. Santin Y (2026) https://BioRender.com/t8m2g29. TFEB: Transcription factor EB; TAC: transverse aortic constriction; PE: phenylephrine; AMPK: AMP-activated protein kinase; PGC-1α-b: peroxisome proliferator-activated receptor gamma coactivator 1-alpha-b.