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Figure 2. Extracellular matrix remodeling across physiological aging and major cardiac disease contexts. Schematic overview of dynamic extracellular matrix (ECM) remodeling and associated changes in myocardial stiffness under physiological and pathological conditions, including aging, myocardial infarction (MI), heart failure (HF), and inherited cardiomyopathies (e.g., hypertrophic cardiomyopathy, HCM).
