fig7
From: The role of selective autophagy in cardiovascular diseases: mechanisms and therapeutic potential
Figure 7. Mechanism of reticulophagy. Three types of reticulophagy: macro-reticulophagy, micro-reticulophagy, and LC3-associated vesicle transport. The inset below illustrates the reticulophagy receptors identified in mammals, which tether the ER to LC3 on the phagophore, including FAM134A/B/C, RTN3L, ATL3, TEX264, SEC62, CCPG1, CALCOCO1, C53, and p62. LC3: microtubule-associated proteins 1A/1B light chain 3B; ER: endoplasmic reticulum; P62: Sequestosome-1; FAM134: family with sequence similarity 134; CCPG1: cell-cycle progression gene 1; TEX264: testis-expressed protein 264; ATL3: atlastin gtpase 3; RTN3L: the long isoform of reticulon 3; CALCOCO1: calcium binding and coiled-coil domain 1; SEC62: secretory 62 homolog.
