fig5

Figure 5. Regulation of lipophagy in macrophages. The binding of ASIC1 to RIP1 leads to the phosphorylation of TFEB, which prevents its nuclear translocation and ultimately inhibits lipophagy. LAL: Lysosomal acid lipase; Wnt1: wnt family member 1; Sirt6: sirtuin 6; TFEB: transcription factor EB; ASIC1: acid-sensing ion channel 1; P62: Sequestosome-1; RIP1: receptor-interacting protein 1; SQSTM1: Sequestosome-1; OPTN: optineurin; NBR1: Neighbor of BRCA1 gene 1 protein; CMA: chaperone-mediated autophagy; ACSL1: acyl-CoA synthetase 1; SCARB2: scavenger receptor class B member 2; HMGB1/2: high mobility group box proteins 1 and 2; HSPA5: heat shock protein family A member 5. AUP1: ancient ubiquitous protein 1; UBE2G2: ubiquitin conjugating enzyme E2 G2.