fig3

Figure 3. Transcriptional activation of hypertrophic gene expression in the LV and RV in response to Kv1.5 KO. (A) Brain natriuretic peptide (BNP) expression in the LV was upregulated in KO males and unchanged in females. (B) Atrial natriuretic factor (ANF) expression in the LV was upregulated in KO males and unchanged in female KO mice. (C) α-myosin heavy chain (α-MHC) expression in the LV was unchanged in male and female KO mice. (D) β- myosin heavy chain (β-MHC) expression was upregulated in KO males and unchanged in female KO mice. (E) BNP expression in the RV was unchanged. (F) ANF expression was upregulated in KO males and unchanged in females. (G) α-MHC expression in the RV was unchanged. (H) β-MHC expression in the RV was upregulated in KO male and female mice. *P < 0.05 by Student’s t-test to compare within-sex differences between KO and Con. Data are expressed as mean ± SEM. Blue: male (M), red: female (F).