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Figure 4. Identification of DhMRs with Trending Expression Changes and Functional Annotations. (A) Distribution of 5hmC in PLGC and healthy individuals at different pathological stages, including CAG/IM, Dys, and Healthy; (B) Clustering analysis to identify clusters with continuous expression changes across healthy, CAG/IM, and Dys states; (C) Enrichment analysis of biological processes for upregulated and downregulated DhMGs. DhMR: Differentially hydroxymethylated region; 5hmC: 5-hydroxymethylcytosine; PLGC: precancerous lesion of gastric cancer; CAG: chronic atrophic gastritis; IM: intestinal metaplasia; Dys: dysplasia; DhMG: differentially hydroxymethylated gene.