fig7

Chronic in utero oxycodone exposure alters placental small EV proteome and fetal cardiomyopathy-linked pathways

Figure 7. KEGG pathway enrichment of downregulated proteins. Dot plot displaying the top 20 significantly enriched KEGG pathways associated with downregulated sEV proteins. Notable pathways include fatty acid degradation, citrate cycle (TCA), and N-glycan biosynthesis, indicating disrupted energy metabolism and glycosylation. Dot size represents gene ratio, and color reflects -log10 P-value. KEGG: Kyoto Encyclopedia of Genes and Genomes; sEV: small extracellular vesicle; TCA: tricarboxylic acid.

Extracellular Vesicles and Circulating Nucleic Acids
ISSN 2767-6641 (Online)
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