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Figure 2. Pathologic alterations in IS-associated serum EVs in the discovery subset using proteomics. Human serum samples in the discovery subset were subjected to LC-MS/MS. DEPros were considered with P-value < 0.05 and |log2foldchange| ≥ 1.0 between the IS and HC groups. (A and B) Heatmap clustering and volcano plot of DEPros screened from MS proteomics; (C and D) GO term analysis. Enrichment in the biological process and cellular component categories, revealing the main pathological pathways of stroke rehabilitation. IS: Ischemic stroke; HC: healthy control; DEPros: differentially expressed proteins; GO: Gene Ontology; BP: biological process; CC: cellular component.