fig2

Figure 2. Exosomal LYPLAL1-DT promotes the malignant phenotype of SCLC cells. Various SCLC cell lines were treated with H446 OE-Exo or H446 OC-Exo. (A-C) The expression level of LYPLAL1-DT was significantly higher in the OE-Exo-treated group compared to the OC-Exo-treated group; (D and E) Cellular proliferation of H446 and DMS114 cells was significantly enhanced in the OE-Exo-treated group relative to their respective controls; (F) Cell invasion and migration were significantly increased in the OE-Exo-treated group (scale bar: 200 μm). Data are presented as mean ± SD. Differences between the two groups were analyzed by Student’s t-test, while comparisons among more than two groups were analyzed by one-way ANOVA. (^*P < 0.05; ^**P < 0.01; ^***P < 0.001; ^****P < 0.0001). LYPLAL1-DT: LYPLAL1 divergent transcript; SCLC: small cell lung cancer; OE-Exo: exosomes derived from LYPLAL1-DT-overexpressing cells; OC-Exo: exosomes derived from overexpression control cells; SD: standard deviation; ANOVA: analysis of variance.