fig3

Figure 3. Synovial fluids of patients with aseptic endoprosthesis loosening contain significantly more CD9⁺ and significantly fewer CD82⁺ EVs than those of PJI patients. Aliquots of marginally preprocessed synovial fluids were individually labeled with anti-CD9, anti-CD63, anti-CD66b, anti-CD82, and anti-HLA-DR antibodies and analyzed by IFCM as depicted in Figure 1. The concentration of recorded EVs is provided as objects/mL synovial fluid. Data are presented as dot plots with median and range. Significances were determined using the Mann-Whitney test. Drawing Software: GraphPad. EV: Extracellular vesicle; PJI: periprosthetic joint infection; IFCM: imaging flow cytometry. ^**P < 0.01; ^****P < 0.0001.