REFERENCES
1. Rahib L, Coffin T, Kenner B. Factors driving pancreatic cancer survival rates. Pancreas. 2025;54:e530-6.
2. Sturm N, Ettrich TJ, Perkhofer L. The impact of biomarkers in pancreatic ductal adenocarcinoma on diagnosis, surveillance and therapy. Cancers. 2022;14:217.
3. Wang S, Zheng Y, Yang F, et al. The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives. Signal Transduct Target Ther. 2021;6:249.
4. Ambrosini G, Dalla Pozza E, Fanelli G, et al. Progressively de-differentiated pancreatic cancer cells shift from glycolysis to oxidative metabolism and gain a quiescent stem state. Cells. 2020;9:1572.
5. Valle S, Martin-Hijano L, Alcalá S, Alonso-Nocelo M, Sainz B Jr. The ever-evolving concept of the cancer stem cell in pancreatic cancer. Cancers. 2018;10:33.
6. Zhao Y, Qin C, Zhao B, et al. Pancreatic cancer stemness: dynamic status in malignant progression. J Exp Clin Cancer Res. 2023;42:122.
7. Lee H, Kim B, Park J, et al. Cancer stem cells: landscape, challenges and emerging therapeutic innovations. Signal Transduct Target Ther. 2025;10:248.
8. Chen CF, Chen Y, Dai K, Chen PL, Riley DJ, Lee WH. A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock. Mol Cell Biol. 1996;16:4691-9.
9. Yoshida S, Tsutsumi S, Muhlebach G, et al. Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis. Proc Natl Acad Sci U S A. 2013;110:E1604-12.
10. Mathieu C, Branco JR, Zancan P, et al. Inhibition of TRAP1 in the C-terminal domain influences mitochondria properties and breast cancer cell metabolism. Biomed Pharmacother. 2026;196:119060.
11. Ramos Rego I, Santos Cruz B, Ambrósio AF, Alves CH. TRAP1 in oxidative stress and neurodegeneration. Antioxidants. 2021;10:1829.
12. Cannino G, Urbani A, Gaspari M, et al. The mitochondrial chaperone TRAP1 regulates F-ATP synthase channel formation. Cell Death Differ. 2022;29:2335-46.
13. Liu D, Hu J, Agorreta J, et al. Tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates genes involved in cell cycle and metastases. Cancer Lett. 2010;296:194-205.
14. Gutierrez A, Archdeacon J, Blagg BSJ. TRAP1 and its therapeutic potential. Bioorg Med Chem Lett. 2025;129:130395.
15. Shan S, Wang T, Sun F, Zhao L, Liang S, Wang Z. Comprehensive pan-cancer analysis of TRAP1 and its experimental validation in hepatocellular carcinoma. Discov Oncol. 2025;17:152.
16. Carmona-Carmona CA, Dalla Pozza E, Ambrosini G, et al. Mitochondrial elongation and OPA1 play crucial roles during the stemness acquisition process in pancreatic ductal adenocarcinoma. Cancers. 2022;14:3432.
17. Sciacovelli M, Guzzo G, Morello V, et al. The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase. Cell Metab. 2013;17:988-99.
18. Cogliati S, Frezza C, Soriano ME, et al. Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell. 2013;155:160-71.
19. Tilokani L, Nagashima S, Paupe V, Prudent J. Mitochondrial dynamics: overview of molecular mechanisms. Essays Biochem. 2018;62:341-60.
20. Zhang X, Qi B, Chen J. Clinical application and drug resistance mechanism of gemcitabine. Front Cell Dev Biol. 2025;13:1702720.
21. Ray B, Gupta B, Mehrotra R. Binding of platinum derivative, oxaliplatin to deoxyribonucleic acid: structural insight into antitumor action. J Biomol Struct Dyn. 2019;37:3838-47.
22. Bæk SØ, Keuper K, Milletti G, et al. Stepwise DNA damage and repair mechanisms at replication forks in response to topoisomerase I inhibition. DNA Repair. 2026;157:103914.
23. Chalabi-Dchar M, Fenouil T, Machon C, et al. A novel view on an old drug, 5-fluorouracil: an unexpected RNA modifier with intriguing impact on cancer cell fate. NAR Cancer. 2021;3:zcab032.
24. Mohamet L, Lea ML, Ward CM. Abrogation of E-cadherin-mediated cellular aggregation allows proliferation of pluripotent mouse embryonic stem cells in shake flask bioreactors. PLoS One. 2010;5:e12921.
25. Turano M, Vicidomini R, Cammarota F, et al. The epithelial to mesenchymal transition in colorectal cancer progression: the emerging role of succinate dehydrogenase alterations and succinate accumulation. Biomedicines. 2023;11:1428.
26. Zhang L, Luo Y, Lv L, Chen S, Liu G, Zhao T. TRAP1 inhibits MARCH5-mediated MIC60 degradation to alleviate mitochondrial dysfunction and apoptosis of cardiomyocytes under diabetic conditions. Cell Death Differ. 2023;30:2336-50.
27. Zhang L, Su N, Luo Y, Chen S, Zhao T. TRAP1 inhibits MIC60 ubiquitination to mitigate the injury of cardiomyocytes and protect mitochondria in extracellular acidosis. Cell Death Discov. 2021;7:389.
28. Faienza F, Lambrughi M, Rizza S, et al. S-nitrosylation affects TRAP1 structure and ATPase activity and modulates cell response to apoptotic stimuli. Biochem Pharmacol. 2020;176:113869.
29. Pridgeon JW, Olzmann JA, Chin LS, Li L. PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol. 2007;5:e172.








