fig8

FGFR1 overexpression promotes resistance to PI3K inhibitor alpelisib in luminal breast cancer cells through receptor tyrosine kinase signaling-mediated activation of the estrogen receptor

Figure 8. FGFR1 overexpression confers alpelisib resistance in T47D cells. (A) Immunoblot analysis of FGFR1 overexpression in T47D/FGFR1 and control T47D/C cells; (B) Dose-response curves of T47D/C and T47D/FGFR1 cells measured with CCK-8 assays; (C) Quantification of IC50 values derived from the dose-response assays in panel B. Statistical differences in IC50 values between the two groups were analyzed using Welch’s t-test. **P < 0.01; (D and E) Clonogenic survival assays of T47D/C (control) and T47D/FGFR1 cells treated with indicated concentrations of alpelisib, performed using the same methodology as in Figure 1D and E. **P < 0.01.

Cancer Drug Resistance
ISSN 2578-532X (Online)

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