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Figure 10. FGFR1 inhibition enhances alpelisib efficacy and synergizes with alpelisib + fluvastatin in T47D cells. (A and B) Synergistic interaction between alpelisib (ALP) and AZD4547 (AZD) in T47D/C and T47D/FGFR1 cells. Combination index (CI) values were calculated using the Chou-Talalay method (as described in Figure 4), with CI < 1 indicating synergism; (C and D) Effect of the alpelisib and AZD4547 combination on colony formation in T47D/C and T47D/FGFR1 cells. The combination treatment led to enhanced inhibition of colony formation; (E and F) Synergy analysis of AZD4547 in combination with alpelisib and fluvastatin. The triple combination (ALP + Fluvastatin + AZD) significantly suppressed cell proliferation, particularly in T47D/FGFR1 cells.