fig1

Figure 1. Metabolic pathways involved in ferroptotic cell death. Green, yellow, brown, purple, blue and gray boxes indicate glycolysis and OXPHOS, PPP, glutaminolysis, energy stress, antioxidant, and ferroptosis pathways, respectively. αKG: α-ketoglutarate; AMPK: AMP-activated protein kinase; G6P: glucose 6-phosphate; GLUT1/SLC2A1: glucose transporter 1; GPX4: glutathione peroxidase 4; GSH: glutathione; HIF: hypoxia-inducible factor; LDH: lactate dehydrogenase; NADPH: nicotinamide adenine dinucleotide phosphate; NRF2: NF-E2-related factor 2; OXPHOS: oxidative phosphorylation; PDH: pyruvate dehydrogenase; PDK: pyruvate dehydrogenase kinase; PPP: pentose phosphate pathway; ROS: reactive oxygen species; SLC7A11: solute carrier family 7 member 11; TCA: tricarboxylic acid; xCT: cystine/glutamate antiporter SLC7A11.