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Figure 5. Inhibition of migration and modulation of RON splicing by compounds IS1 and IS4 in SUIT-2 cells. (A) (Top) Representative pictures of scratch areas in untreated (control) and treated cells during the wound healing assay. Original magnification 5×. (Bottom) Percentage of migration over time (0, 8 and 24 h) of SUIT-2 cells treated with the compounds IS1 and IS4 at concentrations of 4 × IC₅₀. **P < 0.01, ***P < 0.005. (B) (Top) Schemes of RON pre-mRNA variant structures with predicted PCR products are shown on the left. (Bottom) Representative picture of PCR splicing pattern assessment of RON in SUIT-2 cells after 24 h of drug exposure. Original magnification 5×.