REFERENCES
1. The Global Cancer Observatory, Europe Globocan 2018, (2020) 1-2. Available from: https://gco.iarc.fr/today/data/factsheets/populations/908-europe-fact-sheets.pdf. [Last accessed on 19 Nov 2020].
2. Ferlay J, Colombet M, Soerjomataram I, Dyba T, Randi G. Cancer incidence and mortality patterns in Europe: estimates for 40 countries and 25 major cancers in 2018. Eur J Cancer 2018;103:356-87.
3. Wang X, Zhang H, Chen X. Drug resistance and combating drug resistance in cancer. Cancer Drug Resist 2019;2:141-60.
4. Mansoori B, Mohammadi A, Davudian S, Shirjang S, Baradaran B. The different mechanisms of cancer drug resistance : a brief review. Tabriz Univ Med Sci 2017;7:339-48.
5. Longacre M, Snyder N, Sarkar S. Drug resistance in cancer : an overview. Cancers (Basel) 2014;6:1769-92.
6. Xue X, Liang XJ. Overcoming drug efflux-based multidrug resistance in cancer with nanotechnology. Chin J Cancer 2012;31:100-9.
7. Robey RW, Pluchino KM, Hall MD, Fojo AT, Bates SE, Gottesman MM. Revisiting the role of efflux pumps in multidrug-resistant cancer. Nat Rev Cancer 2018;18:452-64.
8. Gener P, Rafael DF, Fernández Y, et al. Cancer stem cells and personalized cancer nanomedicine. Nanomedicine (Lond) 2016;11:307-20.
9. Lepeltier E, Rijo P, Rizzolio F, et al. Nanomedicine to target multidrug resistant tumors. Drug Resist Updat 2020;52:100704.
10. Allocati N, Masulli M, Di Ilio C, Federici L. Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases. Oncogenesis 2018;7:8.
11. Westover D, Zugazagoitia J, Cho BC, Lovly CM, Paz-Ares L. Mechanisms of acquired resistance to first- and second-generation EGFR tyrosine kinase inhibitors. Ann Oncol 2018;29:i10-9.
12. Wu S, Shih J. Management of acquired resistance to EGFR TKI - targeted therapy in advanced non-small cell lung cancer. Mol Cancer 2018;17:1-14.
13. Wang S, Song Y, Liu D. EAI045: the fourth-generation EGFR inhibitor overcoming T790M and C797S resistance. Cancer Lett 2017;385:51-4.
14. Desai A, Yan Y, Gerson SL. Advances in therapeutic targeting of the DNA damage response in cancer. DNA Repair (Amst) 2018;66-67:24-9.
15. Hosoya N, Miyagawa K. Targeting DNA damage response in cancer therapy. Cancer Sci 2014;105:370-88.
16. Li D, Yang L. Olaparib nanoparticles potentiated radiosensitization effects on lung cancer. Int J Nanomedicine 2018;13:8461-72.
17. Mohammad RM, Muqbil I, Lowe L, et al. Broad targeting of resistance to apoptosis in cancer,. Semin Cancer Biol 2015;35:S78-103.
18. Zhou Y, Huang F, Yang Y, et al. Paraptosis-inducing nanomedicine overcomes cancer drug resistance for a potent cancer therapy. Small 2018;14:1702446.
19. Sepand MR, Ranjbar S, Kempson IM, et al. Targeting non-apoptotic cell death in cancer treatment by nanomaterials: Recent advances and future outlook. Nanomedicine 2020;29:102243.
20. Roberti A, Valdes AF, Torrecillas R, Fraga MF, Fernandez AF. Epigenetics in cancer therapy and nanomedicine. Clin Epigenetics 2019;11:1-18.
21. Fardi M, Solali S, Farshdousti Hagh M. Epigenetic mechanisms as a new approach in cancer treatment: an updated review. Genes Dis 2018;5:304-11.
22. Takeshima H, Ushijima T. Accumulation of genetic and epigenetic alterations in normal cells and cancer risk. NPJ Precis Oncol 2019;3:7.
23. Cheng Y, He C, Wang M, et al. Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials. Signal Transduct Target Ther 2019;4:62.
24. Gener P, Seras-franzoso J, Callejo PG, et al. Review article dynamism, sensitivity, and consequences of mesenchymal and stem-like phenotype of cancer cells. Stem Cells Int 2018;2018:4516454.
25. LeBleu VS, Kalluri R. A peek into cancer-associated fibroblasts: origins, functions and translational impact. Dis Model Mech 2018;11:dmm029447.
26. Roma-Rodrigues C, Mendes R, Baptista PV, Fernandes AR. Targeting Tumor Microenvironment for Cancer Therapy. Int J Mol Sci 2019;20:840.
27. Tomita H, Tanaka K, Tanaka T, Hara A. Aldehyde dehydrogenase 1A1 in stem cells and cancer. Oncotarget 2016;7:11018-32.
28. Gener P, Callejo PG, Seras-Franzoso J, et al. The potential of nanomedicine to alter cancer stem cell dynamics: the impact of extracellular vesicles. Nanomedicine (Lond) 2020. doi: 10.2217/nnm-2020-0099
29. Yu AM, Jian C, Yu AH, Tu MJ. RNA therapy: are we using the right molecules? Pharmacol Ther 2019;196:91-104.
30. Gómez-Aguado I, Rodríguez-Castejón J, Vicente-Pascual M, Rodríguez-Gascón A, Solinís MÁ, Del Pozo-Rodríguez A. Nanomedicines to deliver mRNA: state of the art and future perspectives. Nanomaterials (Basel) 2020;10:364.
31. Vaughan HJ, Green JJ, Tzeng SY. Cancer-targeting nanoparticles for combinatorial nucleic acid delivery. Adv Mater 2020;32:e1901081.
32. Rafael D, Gener P, Andrade F, et al. AKT2 siRNA delivery with amphiphilic-based polymeric micelles show efficacy against cancer stem cells. Drug Deliv 2018;25:961-72.
33. Gener P, Rafael D, Seras-Franzoso J, et al. Pivotal Role of AKT2 during Dynamic Phenotypic Change of Breast Cancer Stem Cells. Cancers (Basel) 2019;11:1058.
34. Davis ME, Zuckerman JE, Choi CH, et al. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 2010;464:1067-70.
35. Pearce AK, O’Reilly RK. Insights into Active Targeting of Nanoparticles in Drug Delivery: Advances in Clinical Studies and Design Considerations for Cancer Nanomedicine. Bioconjug Chem 2019;30:2300-11.
36. Tabernero J, Shapiro GI, LoRusso PM, et al. First-in-humans trial of an RNA interference therapeutic targeting VEGF and KSP in cancer patients with liver involvement. Cancer Discov 2013;3:406-17.
37. Schultheis B, Strumberg D, Santel A, et al. First-in-human phase I study of the liposomal RNA interference therapeutic Atu027 in patients with advanced solid tumors. J Clin Oncol 2014;32:4141-8.
38. Wagner MJ, Mitra R, McArthur MJ, et al. Preclinical Mammalian Safety Studies of EPHARNA (DOPC Nanoliposomal EphA2-Targeted siRNA). Mol Cancer Ther 2017;16:1114-23.
39. Demeure MJ, Armaghany T, Ejadi S, et al. A phase I/II study of TKM-080301, a
40. Jo DH, Kim JH, Lee TG, Kim JH. Size, surface charge, and shape determine therapeutic effects of nanoparticles on brain and retinal diseases. Nanomedicine 2015;11:1603-11.
41. Wicki A, Witzigmann D, Balasubramanian V, Huwyler J. Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications. J Control Release 2015;200:138-57.
42. Boyles M, Powell L, Kermanizadeh A, et al. An overview of nanoparticle biocompatibility for their use in nanomedicine. 2017. Available from: https://www.researchgate.net/publication/312334531_An_Overview_of_Nanoparticle_Biocompatibility_for_Their_Use_in_Nanomedicine_Innovation_and_Production. [Last accessed on 19 Nov 2020].
43. Mishra P, Nayak B, Dey R. PEGylation in anti-cancer therapy: an overview. Asian J Pharm Sci 2016;11:337-48.
44. Tran S, DeGiovanni PJ, Piel B, Rai P. Cancer nanomedicine: a review of recent success in drug delivery. Clin Transl Med 2017;6:44.
45. Fülöp T, Kozma GT, Vashegyi I, et al. Liposome-induced hypersensitivity reactions: Risk reduction by design of safe infusion protocols in pigs. J Control Release 2019;309:333-8.
46. Campos J, Severino P, Santini A, et al. Solid lipid nanoparticles (SLN). Nanopharmaceuticals. Elsevier; 2020. pp. 1-15.
47. Bakhtiary Z, Barar J, Aghanejad A, et al. Microparticles containing erlotinib-loaded solid lipid nanoparticles for treatment of non-small cell lung cancer. Drug Dev Ind Pharm 2017;43:1244-53.
48. Soni N, Soni N, Pandey H, Maheshwari R, Kesharwani P, Tekade RK. Augmented delivery of gemcitabine in lung cancer cells exploring mannose anchored solid lipid nanoparticles. J Colloid Interface Sci 2016;481:107-16.
49. Gener P, Montero S, Xandri-Monje H, et al. Zileuton™ loaded in polymer micelles effectively reduce breast cancer circulating tumor cells and intratumoral cancer stem cells. Nanomedicine 2020;24:102106.
50. Yu X, Di Y, Xie C, et al. An in vitro and in vivo study of gemcitabine-loaded albumin nanoparticles in a pancreatic cancer cell line. Int J Nanomedicine 2015;10:6825-34.
51. Zhou Y, Yang J, Rhim JS, Kopeček J. HPMA copolymer-based combination therapy toxic to both prostate cancer stem/progenitor cells and differentiated cells induces durable anti-tumor effects. J Control Release 2013;172:946-53.
52. Ventola CL. Progress in nanomedicine: approved and investigational nanodrugs progress in nanomedicine. Pharmacol Ther 2017;42:742-55.
53. Li Y, Zhang H. Nanoparticle-based drug delivery systems for enhanced tumor-targeting treatment. J Biomed Nanotechnol 2019;15:1-27.
54. Watermann A, Brieger J. Mesoporous Silica nanoparticles as drug delivery vehicles in cancer. Nanomaterials (Basel) 2017;7:189.
55. Gabizon A, Catane R, Uziely B, et al. Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes 1. Cancer Res 1994;54:987-92.
56. Miele E, Spinelli GP, Miele E, Tomao F, Tomao S. Albumin-bound formulation of paclitaxel (Abraxane ® ABI-007) in the treatment of breast cancer. Int J Nanomedicine 2009;4:99-106.
57. Hamad I, Moghimi SM. Critical issues in site-specific targeting of solid tumours: the carrier, the tumour barriers and the bioavailable drug. Expert Opin Drug Deliv 2008;5:205-19.
58. Heo YA, Syed YY, Keam SJ. Pegaspargase: a review in acute lymphoblastic leukaemia. Drugs 2019;79:767-77.
59. Choi YH, Han H. Nanomedicines: current status and future perspectives in aspect of drug delivery and pharmacokinetics. J Pharm Invest 2018;48:43-60.
60. Louie AC. CPX-351: a nanoscale liposomal co-formulation of daunorubicin and cytarabine with unique biodistribution and tumor cell uptake properties. Int J Nanomedicine 2019;14:3819-30.
61. Liu B, Chen Z. Co-delivery of paclitaxel and TOS-cisplatin via TAT-targeted solid lipid nanoparticles with synergistic antitumor activity against cervical cancer. Int J Nanomedicine 2017;12:955-68.
62. Katiyar SS, Muntimadugu E, Rafeeqi TA, Domb AJ, Khan W. Co-delivery of rapamycin- and piperine-loaded polymeric nanoparticles for breast cancer treatment. Drug Deliv 2016;23:2608-16.
63. Khaledi S, Jafari S, Hamidi S, Molavi O, Davaran S. Preparation and characterization of PLGA-PEG-PLGA polymeric nanoparticles for co-delivery of 5-Fluorouracil and Chrysin. J Biomater Sci Polym Ed 2020;31:1107-26.
64. Gabizon AA, Tahover E, Golan T, et al. Pharmacokinetics of mitomycin-c lipidic prodrug entrapped in liposomes and clinical correlations in metastatic colorectal cancer patients. Invest New Drugs 2020;38:1411-20.
65. Chao J, Lin J, Frankel P, et al. Pilot trial of CRLX101 in patients with advanced, chemotherapy-refractory gastroesophageal cancer. J Gastrointest Oncol 2017;8:962-9.
66. Golombek SK, May J, Theek B, Appold L. Tumor targeting via EPR: strategies to enhance patient responses. Adv Drug Deliv Rev 2018;130:17-38.
67. Islam W, Fang J, Imamura T, et al. Augmentation of the enhanced permeability and retention effect with nitric oxide-generating agents improves the therapeutic effects of nanomedicines. Mol Cancer Ther 2018;17:2643-53.
68. Azzopardi EA, Ferguson EL, Thomas DW. The enhanced permeability retention effect: a new paradigm for drug targeting in infection. J Antimicrob Chemother 2013;68:257-74.
69. Xu X, Ho W, Zhang X, et al. Cancer nanomedicine: from targeted delivery to combination therapy. Trends Mol Med 2016;21:223-32.
70. Salvioni L, Rizzuto MA, Bertolini JA, Pandolfi L, Colombo M, Prosperi D. Thirty years of cancer nanomedicine: success, frustration, and hope. Cancers (Basel) 2019;11:1855.
71. Adamo G, Campora S, Ghersi G. Chapter 3 - functionalization of nanoparticles in specific targeting and mechanism release. Elsevier Inc.; 2017. doi: 10.1016/B978-0-323-46142-9/00003-7
72. Subbiah R, Veerapandian M, Yun KS. Nanoparticles: functionalization and multifunctional applications in biomedical sciences. Curr Med Chem 2010;17:4559-77.
73. Thiruppathi R, Mishra S, Ganapathy M, Padmanabhan P, Gulyás B. Nanoparticle functionalization and its potentials for molecular imaging. Adv Sci (Weinh) 2017;4:1600279.
74. Mout R, Moyano DF, Rana S, Rotello VM. Surface functionalization of nanoparticles for nanomedicine. Chem Soc Rev 2012;41:2539-44.
75. Gonda A, Zhao N, Shah JV, et al. Engineering tumor-targeting nanoparticles as vehicles for precision nanomedicine. Med One 2019;4.
76. Valle JW, Armstrong A, Newman C, et al. A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction. Invest New Drugs 2011;29:1029-37.
77. Attia MF, Anton N, Wallyn J, Omran Z, Vandamme TF. An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites. J Pharm Pharmacol 2019;71:1185-98.
78. Zununi Vahed S, Fathi N, Samiei M, Maleki Dizaj S, Sharifi S. Targeted cancer drug delivery with aptamer-functionalized polymeric nanoparticles. J Drug Target 2019;27:292-9.
79. Autio KA, Dreicer R, Anderson J, et al. Safety and Efficacy of BIND-014, a Docetaxel Nanoparticle Targeting Prostate-Specific Membrane Antigen for Patients With Metastatic Castration-Resistant Prostate Cancer: A Phase 2 Clinical Trial. JAMA Oncol 2018;4:1344-51.
80. Lopez S, Perrone E, Bellone S, et al. Preclinical activity of sacituzumab govitecan (IMMU-132 ) in uterine and ovarian carcinosarcomas. Oncotarget 2020;11:560-70.
81. Munster P, Krop IE, LoRusso P, et al. Safety and pharmacokinetics of MM-302, a HER2-targeted antibody-liposomal doxorubicin conjugate, in patients with advanced HER2-positive breast cancer: a phase 1 dose-escalation study. Br J Cancer 2018;119:1086-93.
82. Gener P, Gouveia LP, Sabat GR, et al. Fluorescent CSC models evidence that targeted nanomedicines improve treatment sensitivity of breast and colon cancer stem cells. Nanomedicine 2015;11:1883-92.
83. Souto EB, Doktorovova S, Campos JR, Martins-Lopes P, Silva AM. Surface-tailored anti-HER2/neu-solid lipid nanoparticles for site-specific targeting MCF-7 and BT-474 breast cancer cells. Eur J Pharm Sci 2019;128:27-35.
84. Li F, Lu J, Liu J, et al. A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer. Nat Commun 2017;8:1390.
85. Boondireke S, Léonard M, Durand A, Thanomsub Wongsatayanon B. Encapsulation of monomyristin into polymeric nanoparticles improved its in vitro antiproliferative activity against cervical cancer cells. Colloids Surf B Biointerfaces 2019;176:9-17.
86. Ni W, Li Z, Liu Z, et al. Dual-targeting nanoparticles: codelivery of curcumin and 5-fluorouracil for synergistic treatment of hepatocarcinoma. J Pharm Sci 2019;108:1284-95.
87. van der Meel R, Lammers T, Hennink WE. Cancer nanomedicines: oversold or underappreciated? Expert Opin Drug Deliv 2017;14:1-5.
88. Sepantafar M, Maheronnaghsh R, Mohammadi H, et al. Engineered hydrogels in cancer therapy and diagnosis. Trends Biotechnol 2017;35:1074-87.
89. Villaverde G, Baeza A. Targeting strategies for improving the efficacy of nanomedicine in oncology. Beilstein J Nanotechnol 2019;10:168-81.
90. Tambe V, Maheshwari R, Chourasiya Y, Choudhury H, Gorain B, Tekade RK. Clinical aspects and regulatory requirements for nanomedicines. Basic Fundamentals of Drug Delivery. Elsevier; 2019. pp. 733-52.
91. Miao L, Newby JM, Lin CM, et al. The binding site barrier elicited by tumor associated fibroblasts interferes disposition of nanoparticles in the stroma-vessel type tumors. ACS Nano 2016;10:9243-58.
92. Libutti SK, Tamarkin L, Nilubol N. Targeting the invincible barrier for drug delivery in solid cancers: interstitial fluid pressure. Oncotarget 2018;9:35723-5.
93. Szebeni J, Simberg D, González-Fernández Á, Barenholz Y, Dobrovolskaia MA. Roadmap and strategy for overcoming infusion reactions to nanomedicines. Nat Nanotechnol 2018;13:1100-8.
94. Dobrovolskaia MA, Shurin M, Shvedova AA. Current understanding of interactions between nanoparticles and the immune system. Toxicol Appl Pharmacol 2016;299:78-89.
95. Murayama T, Gotoh N. Patient-derived xenograft models of breast cancer and their application. Cells 2019;8.
96. Gazdar AF, Hirsch FR, Minna JD. From mice to men and back: an assessment of preclinical model systems for the study of lung cancers. J Thorac Oncol 2016;11:287-99.
97. Lammers T, Kiessling F, Ashford M, Hennink W, Crommelin D, Storm G. Cancer nanomedicine: Is targeting our target? Nat Rev Mater 2016;1:16069.
99. Hu H, Lin Z, He B, et al. A novel localized co-delivery system with lapatinib microparticles and paclitaxel nanoparticles in a peritumorally injectable in situ hydrogel. J Control Release 2015;220:189-200.
100. Guo DD, Hong SH, Jiang HL, et al. Synergistic effects of Akt1 shRNA and paclitaxel-incorporated conjugated linoleic acid-coupled poloxamer thermosensitive hydrogel on breast cancer. Biomaterials 2012;33:2272-81.
101. Ruivo CF, Adem B, Silva M, Melo SA. The biology of cancer exosomes: insights and new perspectives. Cancer Res 2017;77:6480-8.
102. Steinbichler TB, Dudás J, Riechelmann H, Skvortsova II. The role of exosomes in cancer metastasis. Semin Cancer Biol 2017;44:170-81.
103. Kim J, Kim TY, Lee MS, Mun JY, Ihm C, Kim SA. Exosome cargo reflects TGF-β1-mediated epithelial-to-mesenchymal transition (EMT) status in A549 human lung adenocarcinoma cells. Biochem Biophys Res Commun 2016;478:643-8.
104. Kosaka N. Decoding the secret of cancer by means of extracellular vesicles. J Clin Med 2016;5:22.
105. Kim MS, Haney MJ, Zhao Y, et al. Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells. Nanomedicine 2016;12:655-64.
