fig5

Figure 5. NRF2 modulators with anticancer activity. Small molecule compound or drugs that directly or indirectly modulate NRF2 activity by either activating or inhibiting NRF2 activity and functions. The benefits and risks of modulating NRF2 pathway activity in patients are not fully captured and understood. However, the development of novel NRF2 inhibitors used in combination with existing anticancer drugs could be rational strategy to arrest and mitigate the emergence of chemoresistance to anticancer agents. NRF2: nuclear factor E2-related factor 2