fig1

Figure 1. Kinetics of emergence of the C797S (G>C) somatic mutant variant during osimertinib treatment cycle. Results are shown as %MVF. For timepoints 0 and 42 C797S was ND. Although results were obtained for del19 and T790M for the day-164 specimen, the remaining specimen QNS for C797S testing at this time point. ND: not detected; QNS: quantity was not sufficient; %MVF: percent minor variant frequency