REFERENCES
2. Waddington CH. The Epigenotype Endeavour 1942. pp. 18-20.
5. Yang Q, Yang Y, Zhou N, Tang K, Lau WB, et al. Epigenetics in ovarian cancer: premise, properties, and perspectives. Mol Cancer 2018;17:109.
6. Rosenberg B, Vancamp L, Krigas T. Inhibition of cell division in escherichia coli by electrolysis products from a platinum electrode. Nature 1965;205:698-9.
7. Rosenberg B, VanCamp L. The successful regression of large solid sarcoma 180 tumors by platinum compounds. Cancer Res 1970;30:1799-802.
8. Wilting RH, Dannenberg JH. Epigenetic mechanisms in tumorigenesis, tumor cell heterogeneity and drug resistance. Drug Resist Updat 2012;15:21-38.
9. Dawson MA, Kouzarides T, Huntly BJ. Targeting epigenetic readers in cancer. N Engl J Med 2012;367:647-57.
10. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, et al. Molecular biology of the cell. 5th ed. New York: Garland Science Publishing, Taylor & Francis Group; 2008.
11. Baylin SB, Ohm JE. Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat Rev Cancer 2006;6:107-16.
12. Esteller M, Silva JM, Dominguez G, Bonilla F, Matias-Guiu X, et al. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J Natl Cancer Inst 2000;92:564-9.
13. Catteau A, Harris WH, Xu CF, Solomon E. Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics. Oncogene 1999;18:1957-65.
14. Gozzi G, Chelbi ST, Manni P, Alberti L, Fonda S, et al. Promoter methylation and downregulated expression of the TBX15 gene in ovarian carcinoma. Oncol Lett 2016;12:2811-9.
15. Li Q, Xue X, Li W, Wang Q, Han L, et al. Heterogeneous DNA methylation status in same-cell subpopulations of ovarian cancer tissues. Tumour Biol 2017;39:1010428317701650.
16. Losi L, Fonda S, Saponaro S, Chelbi ST, Lancellotti C, et al. Distinct DNA methylation profiles in ovarian tumors: opportunities for novel biomarkers. Int J Mol Sci 2018;19.
17. Choi JD, Lee JS. Interplay between epigenetics and genetics in cancer. Genomics Inform 2013;11:164-73.
18. Yang SD, Ahn SH, Kim JI. 3-Oxoacid CoA transferase 1 as a therapeutic target gene for cisplatin-resistant ovarian cancer. Oncol Lett 2018;15:2611-8.
19. Lund RJ, Huhtinen K, Salmi J, Rantala J, Nguyen EV, et al. DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer. Sci Rep 2017;7:1469.
20. Han X, Zhou Y, You Y, Lu J, Wang L, et al. TET1 promotes cisplatin-resistance via demethylating the vimentin promoter in ovarian cancer. Cell Biol Int 2017;41:405-14.
21. Fang F, Munck J, Tang J, Taverna P, Wang Y, et al. The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer. Clin Cancer Res 2014;20:6504-16.
22. Zeller C, Dai W, Steele NL, Siddiq A, Walley AJ, et al. Candidate DNA methylation drivers of acquired cisplatin resistance in ovarian cancer identified by methylome and expression profiling. Oncogene 2012;31:4567-76.
23. Strathdee G, MacKean MJ, Illand M, Brown R. A role for methylation of the hMLH1 promoter in loss of hMLH1 expression and drug resistance in ovarian cancer. Oncogene 1999;18:2335-41.
24. Matei D, Fang F, Shen C, Schilder J, Arnold A, et al. Epigenetic resensitization to platinum in ovarian cancer. Cancer Res 2012;72:2197-205.
25. Ha YN, Sung HY, Yang SD, Chae YJ, Ju W, et al. Epigenetic modification of alpha-N-acetylgalactosaminidase enhances cisplatin resistance in ovarian cancer. Korean J Physiol Pharmacol 2018;22:43-51.
26. Jin C, Yu W, Lou X, Zhou F, Han X, et al. UCHL1 is a putative tumor suppressor in ovarian cancer cells and contributes to cisplatin resistance. J Cancer 2013;4:662-70.
27. Yu W, Jin C, Lou X, Han X, Li L, et al. Global analysis of DNA methylation by Methyl-Capture sequencing reveals epigenetic control of cisplatin resistance in ovarian cancer cell. PLoS One 2011;6:e29450.
28. Olopade OI, Wei M. FANCF methylation contributes to chemoselectivity in ovarian cancer. Cancer Cell 2003;3:417-20.
29. D'Andrea AD. The Fanconi Anemia/BRCA signaling pathway: disruption in cisplatin-sensitive ovarian cancers. Cell Cycle 2003;2:290-2.
30. Taniguchi T, Tischkowitz M, Ameziane N, Hodgson SV, Mathew CG, et al. Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors. Nat Med 2003;9:568-74.
31. Bonito NA, Borley J, Wilhelm-Benartzi CS, Ghaem-Maghami S, Brown R. Epigenetic regulation of the homeobox gene MSX1 associates with platinum-resistant disease in high-grade serous epithelial ovarian cancer. Clin Cancer Res 2016;22:3097-104.
32. Cui L, Liang B, Yang Y, Zhu M, Kwong J, et al. Inhibition of coiled coil domain containing protein 69 enhances platinum-induced apoptosis in ovarian cancer cells. Oncotarget 2017;8:101634-48.
33. de Leon M, Cardenas H, Vieth E, Emerson R, Segar M, Liu Y, Nephew K, Matei D. Transmembrane protein 88 (TMEM88) promoter hypomethylation is associated with platinum resistance in ovarian cancer. Gynecol Oncol 2016;142:539-47.
34. Lum E, Vigliotti M, Banerjee N, Cutter N, Wrzeszczynski KO, et al. Loss of DOK2 induces carboplatin resistance in ovarian cancer via suppression of apoptosis. Gynecol Oncol 2013;130:369-76.
35. Fang F, Cardenas H, Huang H, Jiang G, Perkins SM, et al. Genomic and epigenomic signatures in ovarian cancer associated with resensitization to platinum drugs. Cancer Res 2018;78:631-44.
36. Coley HM, Safuwan NA, Chivers P, Papacharalbous E, Giannopoulos T, et al. The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer. Br J Cancer 2012;106:482-9.
37. Syed N, Coley HM, Sehouli J, Koensgen D, Mustea A, et al. Polo-like kinase Plk2 is an epigenetic determinant of chemosensitivity and clinical outcomes in ovarian cancer. Cancer Res 2011;71:3317-27.
38. Iramaneerat K, Rattanatunyong P, Khemapech N, Triratanachat S, Mutirangura A. HERV-K hypomethylation in ovarian clear cell carcinoma is associated with a poor prognosis and platinum resistance. Int J Gynecol Cancer 2011;21:51-7.
39. Su HY, Lai HC, Lin YW, Liu CY, Chen CK, et al. Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway. Int J Cancer 2010;127:555-67.
40. Nogales V, Reinhold WC, Varma S, Martinez-Cardus A, Moutinho C, et al. Epigenetic inactivation of the putative DNA/RNA helicase SLFN11 in human cancer confers resistance to platinum drugs. Oncotarget 2016;7:3084-97.
41. Nicholson LJ, Smith PR, Hiller L, Szlosarek PW, Kimberley C, et al. Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer. Int J Cancer 2009;125:1454-63.
42. Olkhov-Mitsel E, Bapat B. Strategies for discovery and validation of methylated and hydroxymethylated DNA biomarkers. Cancer Med 2012;1:237-60.
43. Kurdyukov S, Bullock M. DNA methylation analysis: choosing the right method. Biology (Basel) 2016;5:E3.
44. Guilleret I, Losi L, Chelbi ST, Fonda S, Bougel S, et al. DNA methylation profiling of esophageal adenocarcinoma using methylation ligation-dependent macroarray (MLM). Biochem Biophys Res Commun 2016;479:231-7.
45. Kagohara LT, Stein-O'Brien GL, Kelley D, Flam E, Wick HC, et al. Epigenetic regulation of gene expression in cancer: techniques, resources and analysis. Brief Funct Genomics 2018;17:49-63.
46. Cock-Rada A, Weitzman JB. The methylation landscape of tumour metastasis. Biol Cell 2013;105:73-90.
47. Deng J, Wang L, Chen H, Hao J, Ni J, et al. Targeting epithelial-mesenchymal transition and cancer stem cells for chemoresistant ovarian cancer. Oncotarget 2016;7:55771-88.
48. Surana R, Sikka S, Cai W, Shin EM, Warrier SR, et al. Secreted frizzled related proteins: Implications in cancers. Biochim Biophys Acta 2014;1845:53-65.
49. Carnero A, Blanco-Aparicio C, Renner O, Link W, Leal JF. The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications. Curr Cancer Drug Targets 2008;8:187-98.
50. Fazio C, Ricciardiello L. Inflammation and Notch signaling: a crosstalk with opposite effects on tumorigenesis. Cell Death Dis 2016;7:e2515.
51. Volarevic V, Djokovic B, Jankovic MG, Harrell CR, Fellabaum C, et al. Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity. J Biomed Sci 2019;26:25.
52. Rabik CA, Dolan ME. Molecular mechanisms of resistance and toxicity associated with platinating agents. Cancer Treat Rev 2007;33:9-23.
53. Dasari S, Tchounwou PB. Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol 2014;740:364-78.
54. Stewart DJ. Mechanisms of resistance to cisplatin and carboplatin. Crit Rev Oncol Hematol 2007;63:12-31.
55. Holzer AK, Katano K, Klomp LW, Howell SB. Cisplatin rapidly down-regulates its own influx transporter hCTR1 in cultured human ovarian carcinoma cells. Clin Cancer Res 2004;10:6744-9.
56. Howell SB, Safaei R, Larson CA, Sailor MJ. Copper transporters and the cellular pharmacology of the platinum-containing cancer drugs. Mol Pharmacol 2010;77:887-94.
57. Godwin AK, Meister A, O'Dwyer PJ, Huang CS, Hamilton TC, et al. High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. Proc Natl Acad Sci U S A 1992;89:3070-4.
58. Jendzelovsky R, Jendzelovska Z, Hilovska L, Koval J, Mikes J, et al. Proadifen sensitizes resistant ovarian adenocarcinoma cells to cisplatin. Toxicol Lett 2016;243:56-66.
59. Damia G, Broggini M. Platinum resistance in ovarian cancer: role of DNA repair. Cancers (Basel) 2019;11:E119.
60. Nie J, Liu L, Li X, Han W. Decitabine, a new star in epigenetic therapy: the clinical application and biological mechanism in solid tumors. Cancer Lett 2014;354:12-20.
61. Derissen EJ, Beijnen JH, Schellens JH. Concise drug review: azacitidine and decitabine. Oncologist 2013;18:619-24.
62. Li M, Balch C, Montgomery JS, Jeong M, Chung JH, et al. Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer. BMC Med Genomics 2009;2:34.
63. Singh V, Sharma P, Capalash N. DNA methyltransferase-1 inhibitors as epigenetic therapy for cancer. Curr Cancer Drug Targets 2013;13:379-99.
64. Samudio-Ruiz SL, Hudson LG. Increased DNA methyltransferase activity and DNA methylation following epidermal growth factor stimulation in ovarian cancer cells. Epigenetics 2012;7:216-24.
65. Granados ML, Hudson LG, Samudio-Ruiz SL. Contributions of the epidermal growth factor receptor to acquisition of platinum resistance in ovarian cancer cells. PLoS One 2015;10:e0136893.
66. Zhao Y, Li Q, Wu X, Chen P. Upregulation of p27Kip1 by demethylation sensitizes cisplatin-resistant human ovarian cancer SKOV3 cells. Mol Med Rep 2016;14:1659-66.
67. Kritsch D, Hoffmann F, Steinbach D, Jansen L, Mary Photini S, et al. Tribbles 2 mediates cisplatin sensitivity and DNA damage response in epithelial ovarian cancer. Int J Cancer 2017;141:1600-14.
68. Salome M, Campos J, Keeshan K. TRIB2 and the ubiquitin proteasome system in cancer. Biochem Soc Trans 2015;43:1089-94.
69. Zhang S, Xie C. The role of OXCT1 in the pathogenesis of cancer as a rate-limiting enzyme of ketone body metabolism. Life Sci 2017;183:110-5.
70. Berchuck A, Iversen ES, Luo J, Clarke JP, Horne H, et al. Microarray analysis of early stage serous ovarian cancers shows profiles predictive of favorable outcome. Clin Cancer Res 2009;15:2448-55.
71. Lee PS, Teaberry VS, Bland AE, Huang Z, Whitaker RS, et al. Elevated MAL expression is accompanied by promoter hypomethylation and platinum resistance in epithelial ovarian cancer. Int J Cancer 2010;126:1378-89.
72. Yamamoto N, Naraparaju VR, Moore M, Brent LH. Deglycosylation of serum vitamin D3-binding protein by alpha-N-acetylgalactosaminidase detected in the plasma of patients with systemic lupus erythematosus. Clin Immunol Immunopathol 1997;82:290-8.
73. Fang Y, Shen X. Ubiquitin carboxyl-terminal hydrolases: involvement in cancer progression and clinical implications. Cancer Metastasis Rev 2017;36:669-82.
74. Garcia MJ, Benitez J. The Fanconi anaemia/BRCA pathway and cancer susceptibility. Searching for new therapeutic targets. Clin Transl Oncol 2008;10:78-84.
75. Kang MH, Reynolds CP. Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy. Clin Cancer Res 2009;15:1126-32.
76. Karaca B, Atmaca H, Bozkurt E, Kisim A, Uzunoglu S, et al. Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells. Mol Biol Rep 2013;40:3925-33.
77. Geisler JP, Hatterman-Zogg MA, Rathe JA, Buller RE. Frequency of BRCA1 dysfunction in ovarian cancer. J Natl Cancer Inst 2002;94:61-7.
78. Patch AM, Christie EL, Etemadmoghadam D, Garsed DW, George J, et al. Whole-genome characterization of chemoresistant ovarian cancer. Nature 2015;521:489-94.
79. Fang F, Balch C, Schilder J, Breen T, Zhang S, et al. A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer. Cancer 2010;116:4043-53.
80. Fu S, Hu W, Iyer R, Kavanagh JJ, Coleman RL, et al. Phase 1b-2a study to reverse platinum resistance through use of a hypomethylating agent, azacitidine, in patients with platinum-resistant or platinum-refractory epithelial ovarian cancer. Cancer 2011;117:1661-9.
81. Li S, Wei X, He J, Tian X, Yuan S, et al. Plasminogen activator inhibitor-1 in cancer research. Biomed Pharmacother 2018;105:83-94.
82. Pan JX, Qu F, Wang FF, Xu J, Mu LS, et al. Aberrant SERPINE1 DNA methylation is involved in carboplatin induced epithelial-mesenchymal transition in epithelial ovarian cancer. Arch Gynecol Obstet 2017;296:1145-52.
83. Glasspool RM, Brown R, Gore ME, Rustin GJ, McNeish IA, et al. A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer. Br J Cancer 2014;110:1923-9.
85. Delage B, Fennell DA, Nicholson L, McNeish I, Lemoine NR, et al. Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer. Int J Cancer 2010;126:2762-72.
86. Byrne C, Divekar SD, Storchan GB, Parodi DA, Martin MB. Metals and breast cancer. J Mammary Gland Biol Neoplasia 2013;18:63-73.
87. Aebi S, Christen R, Naredi P, Cenni B, Fink D, et al. Synergy between cisplatin and an inhibitor of S-adenosylmethionine dependent transmethylation in human ovarian adenocarcinoma cells. Int J Oncol 1997;11:869-74.
89. Maradeo ME, Cairns P. Translational application of epigenetic alterations: ovarian cancer as a model. FEBS Lett 2011;585:2112-20.
90. Nguyen HT, Tian G, Murph MM. Molecular epigenetics in the management of ovarian cancer: are we investigating a rational clinical promise? Front Oncol 2014;4:71.
91. Wischnewski F, Pantel K, Schwarzenbach H. Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells. Mol Cancer Res 2006;4:339-49.
92. Cacan E, Ali MW, Boyd NH, Hooks SB, Greer SF. Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance. PLoS One 2014;9:e87455.
93. Steele N, Finn P, Brown R, Plumb JA. Combined inhibition of DNA methylation and histone acetylation enhances gene re-expression and drug sensitivity in vivo. Br J Cancer 2009;100:758-63.
94. Liu X, Yu Y, Zhang J, Lu C, Wang L, et al. HDAC1 silencing in ovarian cancer enhances the chemotherapy response. Cell Physiol Biochem 2018;48:1505-18.
95. Cacan E. Histone Deacetylase-1-mediated Suppression of FAS in Chemoresistant Ovarian Cancer Cells. Anticancer Res 2016;36:2819-26.
96. Hulin-Curtis SL, Davies JA, Jones R, Hudson E, Hanna L, et al. Histone deacetylase inhibitor trichostatin A sensitises cisplatin-resistant ovarian cancer cells to oncolytic adenovirus. Oncotarget 2018;9:26328-41.
97. Falchook GS, Fu S, Naing A, Hong DS, Hu W, et al. Methylation and histone deacetylase inhibition in combination with platinum treatment in patients with advanced malignancies. Invest New Drugs 2013;31:1192-200.
99. Piletic K, Kunej T. MicroRNA epigenetic signatures in human disease. Arch Toxicol 2016;90:2405-19.
100. Calin GA, Croce CM. MicroRNA-cancer connection: the beginning of a new tale. Cancer Res 2006;66:7390-4.
101. Moreno-Moya JM, Vilella F, Simon C. MicroRNA: key gene expression regulators. Fertil Steril 2014;101:1516-23.
102. Kloosterman WP, Plasterk RH. The diverse functions of microRNAs in animal development and disease. Dev Cell 2006;11:441-50.
103. Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A 2007;104:15805-10.
104. Garzon R, Liu S, Fabbri M, Liu Z, Heaphy CE, et al. MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood 2009;113:6411-8.
105. Zhang S, Lu Z, Unruh AK, Ivan C, Baggerly KA, et al. Clinically relevant microRNAs in ovarian cancer. Mol Cancer Res 2015;13:393-401.
106. Vera O, Jimenez J, Pernia O, Rodriguez-Antolin C, Rodriguez C, et al. DNA methylation of miR-7 is a mechanism involved in platinum response through MAFG overexpression in cancer cells. Theranostics 2017;7:4118-34.
107. Boyerinas B, Park SM, Hau A, Murmann AE, Peter ME. The role of let-7 in cell differentiation and cancer. Endocr Relat Cancer 2010;17:F19-36.
108. Cai J, Yang C, Yang Q, Ding H, Jia J, et al. Deregulation of let-7e in epithelial ovarian cancer promotes the development of resistance to cisplatin. Oncogenesis 2013;2:e75.
109. Xiao M, Cai J, Cai L, Jia J, Xie L, et al. Let-7e sensitizes epithelial ovarian cancer to cisplatin through repressing DNA double strand break repair. J Ovarian Res 2017;10:24.
110. Zhao HM, Wei W, Sun YH, Gao JH, Wang Q, et al. MicroRNA-9 promotes tumorigenesis and mediates sensitivity to cisplatin in primary epithelial ovarian cancer cells. Tumour Biol 2015;36:6867-73.
111. Sun C, Li N, Yang Z, Zhou B, He Y, et al. MiR-9 regulation of BRCA1 and ovarian cancer sensitivity to cisplatin and PARP inhibition. J Natl Cancer Inst 2013;105:1750-8.
112. Pink RC, Samuel P, Massa D, Caley DP, Brooks SA, et al. The passenger strand, miR-21-3p, plays a role in mediating cisplatin resistance in ovarian cancer cells. Gynecol Oncol 2015;137:143-51.
113. Jin AH, Wei ZL. Molecular mechanism of increased sensitivity of cisplatin to ovarian cancer by inhibition of microRNA-23a expression. Int J Clin Exp Med 2015;8:13329-34.
114. Samuel P, Pink RC, Caley DP, Currie JM, Brooks SA, Carter DR. Over-expression of miR-31 or loss of KCNMA1 leads to increased cisplatin resistance in ovarian cancer cells. Tumour Biol 2016;37:2565-73.
115. Lv T, Song K, Zhang L, Li W, Chen Y, et al. MiRNA-34a decreases ovarian cancer cell proliferation and chemoresistance by targeting HDAC1. Biochem Cell Biol 2018;96:663-71.
116. Li B, Chen H, Wu N, Zhang WJ, Shang LX. Deregulation of miR-128 in ovarian cancer promotes cisplatin resistance. Int J Gynecol Cancer 2014;24:1381-8.
117. Yang C, Cai J, Wang Q, Tang H, Cao J, et al. Epigenetic silencing of miR-130b in ovarian cancer promotes the development of multidrug resistance by targeting colony-stimulating factor 1. Gynecol Oncol 2012;124:325-34.
118. Zhao H, Liu S, Wang G, Wu X, Ding Y, et al. Expression of miR-136 is associated with the primary cisplatin resistance of human epithelial ovarian cancer. Oncol Rep 2015;33:591-8.
119. Kodahl AR, Lyng MB, Binder H, Cold S, Gravgaard K, et al. Novel circulating microRNA signature as a potential non-invasive multi-marker test in ER-positive early-stage breast cancer: a case control study. Mol Oncol 2014;8:874-83.
120. Cazzoli R, Buttitta F, Di Nicola M, Malatesta S, Marchetti A, et al. MicroRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer. J Thorac Oncol 2013;8:1156-62.
121. Miles GD, Seiler M, Rodriguez L, Rajagopal G, Bhanot G. Identifying microRNA/mRNA dysregulations in ovarian cancer. BMC Res Notes 2012;5:164.
122. Jiang Y, Jiang J, Jia H, Qiao Z, Zhang J. Recovery of miR-139-5p in ovarian cancer reverses cisplatin resistance by targeting C-Jun. Cell Physiol Biochem 2018;51:129-41.
123. Fabrizio FP, Sparaneo A, Trombetta D, Muscarella LA. Epigenetic versus genetic deregulation of the KEAP1/NRF2 axis in solid tumors: focus on methylation and noncoding RNAs. Oxid Med Cell Longev 2018;2018:2492063.
124. van Jaarsveld MT, Helleman J, Boersma AW, van Kuijk PF, van Ijcken WF, et al. MiR-141 regulates KEAP1 and modulates cisplatin sensitivity in ovarian cancer cells. Oncogene 2013;32:4284-93.
125. Deng Y, Zhao F, Hui L, Li X, Zhang D, et al. Suppressing miR-199a-3p by promoter methylation contributes to tumor aggressiveness and cisplatin resistance of ovarian cancer through promoting DDR1 expression. J Ovarian Res 2017;10:50.
126. Zhao H, Bi T, Qu Z, Jiang J, Cui S, et al. Expression of miR-224-5p is associated with the original cisplatin resistance of ovarian papillary serous carcinoma. Oncol Rep 2014;32:1003-12.
127. Zhou Y, Chen Q, Qin R, Zhang K, Li H. MicroRNA-449a reduces cell survival and enhances cisplatin-induced cytotoxicity via downregulation of NOTCH1 in ovarian cancer cells. Tumour Biol 2014;35:12369-78.
128. Arrighetti N, Cossa G, De Cecco L, Stucchi S, Carenini N, et al. PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells. Toxicol Appl Pharmacol 2016;310:9-19.
129. Chen W, Zeng W, Li X, Xiong W, Zhang M, et al. MicroRNA-509-3p increases the sensitivity of epithelial ovarian cancer cells to cisplatin-induced apoptosis. Pharmacogenomics 2016;17:187-97.
130. Chen W, Du J, Li X, Su J, Huang Y, et al. MiR-509-3p promotes cisplatin-induced apoptosis in ovarian cancer cells through the regulation of anti-apoptotic genes. Pharmacogenomics 2017;18:1671-82.
131. Niu L, Ni H, Hou Y, Du Q, Li H. MiR-509-3p enhances platinum drug sensitivity in ovarian cancer. Gene 2019;686:63-7.
132. Zhang J, Liu L, Sun Y, Xiang J, Zhou D, et al. MicroRNA-520g promotes epithelial ovarian cancer progression and chemoresistance via DAPK2 repression. Oncotarget 2016;7:26516-34.
133. Ottevanger PB. Ovarian cancer stem cells more questions than answers. Semin Cancer Biol 2017;44:67-71.
134. Wei Z, Liu Y, Wang Y, Zhang Y, Luo Q, et al. Downregulation of Foxo3 and TRIM31 by miR-551b in side population promotes cell proliferation, invasion, and drug resistance of ovarian cancer. Med Oncol 2016;33:126.
135. Fuss JO, Tainer JA. XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase. DNA Repair (Amst) 2011;10:697-713.
136. Zhao H, Yu X, Ding Y, Zhao J, Wang G, et al. MiR-770-5p inhibits cisplatin chemoresistance in human ovarian cancer by targeting ERCC2. Oncotarget 2016;7:53254-68.
137. Bruchim I, Werner H. Targeting IGF-1 signaling pathways in gynecologic malignancies. Expert Opin Ther Targets 2013;17:307-20.
138. Zhang Y, Huang S, Guo Y, Li L. MiR-1294 confers cisplatin resistance in ovarian Cancer cells by targeting IGF1R. Biomed Pharmacother 2018;106:1357-63.
139. Stuckrath I, Rack B, Janni W, Jager B, Pantel K, et al. Aberrant plasma levels of circulating miR-16, miR-107, miR-130a and miR-146a are associated with lymph node metastasis and receptor status of breast cancer patients. Oncotarget 2015;6:13387-401.
140. Wilczyński M, Zytko E, Szymanska B, Dzieniecka M, Nowak M, et al. Expression of miR-146a in patients with ovarian cancer and its clinical significance. Oncol Lett 2017;14:3207-14.
141. Benson EA, Skaar TC, Liu Y, Nephew KP, Matei D. Carboplatin with decitabine therapy, in recurrent platinum resistant ovarian cancer, alters circulating mirnas concentrations: a pilot study. PLoS One 2015;10:e0141279.
142. Schwarzenbach H. The clinical relevance of circulating, exosomal miRNAs as biomarkers for cancer. Expert Rev Mol Diagn 2015;15:1159-69.
143. Kuhlmann JD, Chebouti I, Kimmig R, Buderath P, Reuter M, et al. Extracellular vesicle-associated miRNAs in ovarian cancer - design of an integrated NGS-based workflow for the identification of blood-based biomarkers for platinum-resistance. Clin Chem Lab Med 2018; doi: 10.1515/cclm-2018-1048.
144. Wiedemeyer WR, Beach JA, Karlan BY. Reversing platinum resistance in high-grade serous ovarian carcinoma: targeting BRCA and the homologous recombination system. Front Oncol 2014;4:34.
145. Fell VL, Schild-Poulter C. The Ku heterodimer: function in DNA repair and beyond. Mutat Res Rev Mutat Res 2015;763:15-29.
146. Choi YE, Meghani K, Brault ME, Leclerc L, He YJ, et al. Platinum and PARP inhibitor resistance due to overexpression of MicroRNA-622 in BRCA1-mutant ovarian cancer. Cell Rep 2016;14:429-39.
147. Yu X, Chen Y, Tian R, Li J, Li H, et al. MiRNA-21 enhances chemoresistance to cisplatin in epithelial ovarian cancer by negatively regulating PTEN. Oncol Lett 2017;14:1807-10.
148. Chan JK, Blansit K, Kiet T, Sherman A, Wong G, et al. The inhibition of miR-21 promotes apoptosis and chemosensitivity in ovarian cancer. Gynecol Oncol 2014;132:739-44.
149. Liu S, Fang Y, Shen H, Xu W, Li H. Berberine sensitizes ovarian cancer cells to cisplatin through miR-21/PDCD4 axis. Acta Biochim Biophys Sin (Shanghai) 2013;45:756-62.
150. Liu W, Wang S, Zhou S, Yang F, Jiang W, et al. A systems biology approach to identify microRNAs contributing to cisplatin resistance in human ovarian cancer cells. Mol Biosyst 2017;13:2268-76.
151. Yu PN, Yan MD, Lai HC, Huang RL, Chou YC, et al. Downregulation of miR-29 contributes to cisplatin resistance of ovarian cancer cells. Int J Cancer 2014;134:542-51.
152. Han X, Zhen S, Ye Z, Lu J, Wang L, et al. A feedback loop between miR-30a/c-5p and DNMT1 mediates cisplatin resistance in ovarian cancer cells. Cell Physiol Biochem 2017;41:973-86.
153. Liu J, Wu X, Liu H, Liang Y, Gao X, et al. Expression of microRNA-30a-5p in drug-resistant and drug-sensitive ovarian cancer cell lines. Oncol Lett 2016;12:2065-70.
154. Srivastava AK, Han C, Zhao R, Cui T, Dai Y, et al. Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells. Proc Natl Acad Sci U S A 2015;112:4411-6.
155. Liu L, Guo J, Yu L, Cai J, Gui T, et al. MiR-101 regulates expression of EZH2 and contributes to progression of and cisplatin resistance in epithelial ovarian cancer. Tumour Biol 2014;35:12619-26.
156. Li H, Xu H, Shen H, Li H. MicroRNA-106a modulates cisplatin sensitivity by targeting PDCD4 in human ovarian cancer cells. Oncol Lett 2014;7:183-8.
157. Rao YM, Shi HR, Ji M, Chen CH. MiR-106a targets Mcl-1 to suppress cisplatin resistance of ovarian cancer A2780 cells. J Huazhong Univ Sci Technolog Med Sci 2013;33:567-72.
158. Kong F, Sun C, Wang Z, Han L, Weng D, et al. MiR-125b confers resistance of ovarian cancer cells to cisplatin by targeting pro-apoptotic Bcl-2 antagonist killer 1. J Huazhong Univ Sci Technolog Med Sci 2011;31:543.
159. Li N, Yang L, Wang H, Yi T, Jia X, et al. MiR-130a and MiR-374a Function as Novel Regulators of Cisplatin Resistance in Human Ovarian Cancer A2780 Cells. PLoS One 2015;10:e0128886.
160. Zhang X, Huang L, Zhao Y, Tan W. Downregulation of miR-130a contributes to cisplatin resistance in ovarian cancer cells by targeting X-linked inhibitor of apoptosis (XIAP) directly. Acta Biochim Biophys Sin (Shanghai) 2013;45:995-1001.
161. Yang L, Li N, Wang H, Jia X, Wang X, et al. Altered microRNA expression in cisplatin-resistant ovarian cancer cells and upregulation of miR-130a associated with MDR1/P-glycoprotein-mediated drug resistance. Oncol Rep 2012;28:592-600.
162. Sorrentino A, Liu CG, Addario A, Peschle C, Scambia G, et al. Role of microRNAs in drug-resistant ovarian cancer cells. Gynecol Oncol 2008;111:478-86.
163. Zong C, Wang J, Shi TM. MicroRNA 130b enhances drug resistance in human ovarian cancer cells. Tumour Biol 2014;35:12151-6.
164. Chen S, Jiao JW, Sun KX, Zong ZH, Zhao Y. MicroRNA-133b targets glutathione S-transferase pi expression to increase ovarian cancer cell sensitivity to chemotherapy drugs. Drug Des Devel Ther 2015;9:5225-35.
165. Li X, Chen W, Jin Y, Xue R, Su J, et al. MiR-142-5p enhances cisplatin-induced apoptosis in ovarian cancer cells by targeting multiple anti-apoptotic genes. Biochem Pharmacol 2019;161:98-112.
166. Xu M, Xiao J, Chen M, Yuan L, Li J, et al. MiR1495p promotes chemotherapeutic resistance in ovarian cancer via the inactivation of the Hippo signaling pathway. Int J Oncol 2018;52:815-27.
167. He J, Yu JJ, Xu Q, Wang L, Zheng JZ, et al. Downregulation of ATG14 by EGR1-MIR152 sensitizes ovarian cancer cells to cisplatin-induced apoptosis by inhibiting cyto-protective autophagy. Autophagy 2015;11:373-84.
168. Xiang Y, Ma N, Wang D, Zhang Y, Zhou J, et al. MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine. Oncogene 2014;33:378-86.
169. Sun KX, Jiao JW, Chen S, Liu BL, Zhao Y. MicroRNA-186 induces sensitivity of ovarian cancer cells to paclitaxel and cisplatin by targeting ABCB1. J Ovarian Res 2015;8:80.
170. Zhu X, Shen H, Yin X, Long L, Xie C, et al. MiR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin. Oncogene 2016;35:323-32.
171. Cui Y, Wu F, Tian D, Wang T, Lu T, et al. MiR-199a-3p enhances cisplatin sensitivity of ovarian cancer cells by targeting ITGB8. Oncol Rep 2018;39:1649-57.
172. Wang Z, Ting Z, Li Y, Chen G, Lu Y, et al. MicroRNA-199a is able to reverse cisplatin resistance in human ovarian cancer cells through the inhibition of mammalian target of rapamycin. Oncol Lett 2013;6:789-94.
173. Liu MX, Siu MK, Liu SS, Yam JW, Ngan HY, et al. Epigenetic silencing of microRNA-199b-5p is associated with acquired chemoresistance via activation of JAG1-Notch1 signaling in ovarian cancer. Oncotarget 2014;5:944-58.
174. Zhu X, Shen H, Yin X, Long L, Chen X, et al. IL-6R/STAT3/miR-204 feedback loop contributes to cisplatin resistance of epithelial ovarian cancer cells. Oncotarget 2017;8:39154-66.
175. Lin M, Xia B, Qin L, Chen H, Lou G. S100A7 regulates ovarian cancer cell metastasis and chemoresistance through MAPK signaling and is targeted by miR-330-5p. DNA Cell Biol 2018;37:491-500.
176. Liu R, Guo H, Lu S. MiR-335-5p restores cisplatin sensitivity in ovarian cancer cells through targeting BCL2L2. Cancer Med 2018;7:4598-609.
177. Cao L, Wan Q, Li F, Tang CE. MiR-363 inhibits cisplatin chemoresistance of epithelial ovarian cancer by regulating snail-induced epithelial-mesenchymal transition. BMB Rep 2018;51:456-61.
178. Ye G, Fu G, Cui S, Zhao S, Bernaudo S, et al. MicroRNA 376c enhances ovarian cancer cell survival by targeting activin receptor-like kinase 7: implications for chemoresistance. J Cell Sci 2011;124:359-68.
179. Zou J, Liu L, Wang Q, Yin F, Yang Z, et al. Downregulation of miR-429 contributes to the development of drug resistance in epithelial ovarian cancer by targeting ZEB1. Am J Transl Res 2017;9:1357-68.
180. Wu H, Xiao Z, Zhang H, Wang K, Liu W, et al. MiR-489 modulates cisplatin resistance in human ovarian cancer cells by targeting Akt3. Anticancer Drugs 2014;25:799-809.
181. Tian J, Xu YY, Li L, Hao Q. MiR-490-3p sensitizes ovarian cancer cells to cisplatin by directly targeting ABCC2. Am J Transl Res 2017;9:1127-38.
182. Xu S, Fu GB, Tao Z, OuYang J, Kong F, et al. MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1. Oncotarget 2015;6:26457-71.
183. van Jaarsveld MT, van Kuijk PF, Boersma AW, Helleman J, van IWF, et al. MiR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway. Mol Cancer 2015;14:196.
184. Qin X, Sun L, Wang J. Restoration of microRNA-708 sensitizes ovarian cancer cells to cisplatin via IGF2BP1/Akt pathway. Cell Biol Int 2017;41:1110-8.
185. Wu DD, Li XS, Meng XN, Yan J, Zong ZH. MicroRNA-873 mediates multidrug resistance in ovarian cancer cells by targeting ABCB1. Tumour Biol 2016;37:10499-506.
186. Brozovic A, Duran GE, Wang YC, Francisco EB, Sikic BI. The miR-200 family differentially regulates sensitivity to paclitaxel and carboplatin in human ovarian carcinoma OVCAR-3 and MES-OV cells. Mol Oncol 2015;9:1678-93.