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Figure 1. Detailed Experimental Procedure of this Study. (A) Clinical Retrospective Study Workflow. Clinical retrospective analysis comparing the degrees of hepatic inflammation, fibrosis, and steatosis among 161 colorectal cancer liver metastasis patients in the OCG and NCG groups; (B) Animal Experimental Workflow. Mice were randomized into Control, OXA, and OCordy groups. Acute DIFLD was induced by OXA injection, with cordycepin administered orally. Liver injury was evaluated via histopathology, serum biochemistry, oxidative stress markers, and integrated metabolomics and proteomics to elucidate therapeutic mechanisms. CCG: Chemotherapy group; OCG: Oxaliplatin chemotherapy group; NCG: Non-chemotherapy group; OXA: Oxaliplatin; OCordy: Oxaliplatin plus cordycepin; CRC: colorectal cancer; CRLM: colorectal cancer liver metastasis; DIFLD: drug-induced fatty liver disease; SPSS: Statistical Package for the Social Sciences.