fig1

Figure 1. Disease progression of MAFLD and the immune landscape of associated HCC. Created in BioRender. Han, H. (2025) https://BioRender.com/qwm30hm. MAFLD: Metabolic-associated fatty liver disease; HCC: hepatocellular carcinoma; NKT: natural killer T; LIGHT: tumor necrosis factor superfamily member 14; CD4⁺: cluster of differentiation 4 positive; IFNγ: interferon gamma; GZMB: granzyme B; CD8⁺: cluster of differentiation 8 positive; Treg: regulatory T cell; CXCR2: C-X-C motif chemokine receptor 2; NETs: neutrophil extracellular traps; TREM1/2: triggering receptor expressed on myeloid cells 1/2; MDSCs: myeloid-derived suppressor cells; cDCs: conventional dendritic cells; XCR1: X-C motif chemokine receptor 1; MASH: metabolic-associated steatohepatitis.