fig3

Figure 3. Correlations between clinical features and FA_score in HCC patients. FA-associated DEGs were used to establish an FA scoring system. (A) FA_score was higher in patients with advanced AJCC stage (Stage III+IV) compared with early stage (Stage I+II); (B) Patients with high FA_score had shorter OS than those with low FA_score; (C) High-frequency mutated genes in low and high FA_score groups, with TP53 and MUC16 ranking highest in both groups; (D) TMB was higher in the low FA_score group compared with the high FA_score group; (E and F) Patients stratified into four groups based on TMB and FA_score; the H-TMB L-FA_score cohort showed prolonged OS compared with the L-TMB H-FA_score cohort; (G) Immune cell infiltration patterns validated between low and high FA_score groups. FA: Fatty acid; FA_score: fatty acid-related score; HCC: hepatocellular carcinoma; DEGs: differentially expressed genes; AJCC: American Joint Committee on Cancer; OS: overall survival; TMB: tumor mutation burden; H: high; L: low.