fig2

Figure 2. Conceptual evolution in HCC management, progressing from stage (monoparametric) to therapeutic (multiparametric) hierarchy. The various versions of the BCLC algorithm are shown as years in green. HCC: Hepatocellular carcinoma; BCLC: Barcelona Clinic Liver Cancer; ESMO: European Society of Medical Oncology; AASLD: American Association for the Study of the Liver; EASL: European Association for the Study of the Liver.