fig1

Figure 1. Multiparametric therapeutic hierarchy and clinical therapeutic intents. The concept of the converse therapeutic hierarchy is depicted with a dashed and faded arrow, as the evidence supporting this concept remains weak. Adapted from Vitale et al.^[5]. © 2023 Elsevier. Adapted with permission. All rights reserved. AFP: Alpha-fetoprotein; PIVKA-II: protein induced by vitamin K absence II; LDLT: living donor liver transplantation; DCD: donor after circulatory death; DBD: donor after brain death; MELD: model for end-stage liver disease; CRPH: clinically relevant portal hypertension; TACE: transarterial chemoembolisation; PVT: portal vein thrombosis; PS: performance status; SD: stable disease; PD: progressive disease.