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Figure 4. Oncogenic Mutations and Glucose Metabolic Dysregulation in CCA: Therapeutic Targets and Metabolic Shifts. This figure illustrates the upregulation of key glycolytic enzymes (highlighted in red) and the associated metabolites involved in the metabolic alterations observed in cholangiocarcinoma. Additionally, it depicts common oncogenic mutations that modulate glucose metabolic reprogramming in CCA. The dotted arrows represent the regulation of glycolytic enzyme alterations and glucose metabolism dysregulation driven by common oncogenic mutations in CCA. Therapeutic targets are indicated adjacent to each corresponding oncogenic mutation to highlight potential intervention points. Created in BioRender.
