fig1

Figure 1. Fitness evaluation within the multiparametric therapeutic hierarchy. Proposal for modifying the original algorithm to provide a more detailed assessment of patient fitness across various treatment stages. At each stage, the impact of fitness on treatment choices varies depending on the radicality/invasiveness of the intervention - higher in liver transplantation, moderate in liver resection, and low/marginal in locoregional/systemic therapies. (Modified from Vitale et al.^[5]). CCI: Charlson comorbidity index.