fig1

Figure 1. HBV life cycle. The HBV life cycle and the sites of action of entry inhibitors, NAs, RNAi therapeutic agents, CAMs, and NAPs are shown. HBV: Hepatitis B virus; NAs: nucleos(t)ide analog; RNAi: RNA interference; CAMs: capsid assembly modulators; NAPs: nucleic-acid polymers; NTCP: sodium taurocholate cotransporting polypeptide; SVPs: subviral particles; HBsAg: hepatitis B surface antigen; HBeAg: hepatitis B e antigen; ER: endoplasmic reticulum; rcDNA: relaxed circular DNA; cccDNA: covalently closed circular DNA.