Volume 7, Issue 1 (2026) – 21 articles
Cover Picture: This cover artwork features the wild goose (a traditional symbol of long-distance communication in Chinese culture) as its central visual element, representing the essential role of extracellular vesicles as intercellular messengers. The goose's body is vertically divided by a golden beam of light into red-gold and blue-silver halves, symbolizing the dual role of extracellular vesicles in disease. The warm-toned left side represents the "good" aspect as a therapeutic vehicle, with vesicles cascading like golden starlight. A healer, depicted as a fusion of a traditional herbalist and a modern physician, receives these vesicles, symbolizing healing and the preservation of life. The cool-toned right side represents the "evil" aspect as a disease biomarker, with vesicles drifting like fireflies in the night and being captured by a scientist for early diagnosis. The "suitcase" held in the goose's beak symbolizes the ability of extracellular vesicles to package cargo and transmit information across biological boundaries. The cargo inside glows half gold and half blue, metaphorically illustrating how "a single moment of thought" determines the divergent destinies of good and evil. The "Dome of Light" formed above by the goose's wings, together with the "River of Time" below reflecting 80 years of scientific milestones, creates a narrative space where science and culture intertwine. The red seal at the center of the composition, inscribed "The Two-Faced Messenger," along with the inscriptions on both sides - "Goodness: Healing the World" and "Evil: Revealing the Truth" - echoes the interplay between opposing roles. The design integrates the aesthetics of Chinese negative space and the symbolic duality found in Peking Opera masks into the context of modern science, offering a visual interpretation of extracellular vesicles as a "two-faced messenger shaped by a single thought."
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Back Cover Picture: This cover artwork features the Peking Opera mask as its central visual motif. The mask is vertically divided into red and white halves by a golden beam of light, symbolizing the dual role of extracellular vesicles in disease - where "a single moment of thought" determines the opposing extremes of good and evil. The red half represents loyalty, courage, and righteousness, corresponding to the therapeutic functions of extracellular vesicles. Its surface is composed of hexagonal lipid bilayer structures embedded with luminous therapeutic cargo, including nanomedicines, microRNAs, and proteins. Vesicles cascade downward like golden starlight and are received by a modern medical researcher, symbolizing healing and life-saving intervention. The white half represents cunning, treachery, and caution, corresponding to the diagnostic value of extracellular vesicles as disease biomarkers. Its surface features microscopic symbolic elements - microscopes, detection chips, and DNA strands. Vesicles drift downward like fireflies in the night and are captured by a scientist for early diagnosis. At the center of the mask's forehead, where the red and white halves meet, lies a luminous "courier pouch," symbolizing the fundamental role of extracellular vesicles in packaging cargo and transmitting information across biological boundaries. Inside the pouch, the cargo glows half gold and half blue, illustrating the dual destinies carried by a single messenger. Above the mask, pheasant feathers (Lingzi, a distinctive ornamental element in Peking Opera costumes) intertwine with vesicles to form a "Dome of Light," metaphorically representing the authority and far-reaching influence of extracellular vesicles as mediators of intercellular communication. Below flows the "River of Time," reflecting key milestones from 80 years of research and symbolizing the continuous accumulation of knowledge. At the top center, the title "Extracellular Vesicles" appears in large, bold lettering, with the calligraphic inscription "A Moment of Thought" positioned above it. On the left and right sides, smaller inscriptions read "Goodness: Healing the World" and "Evil: Revealing the Truth," echoing the red and white halves. At the center of the forehead, a circular red seal inscribed "The Two-Faced Messenger" highlights the central theme. The design integrates the dualistic philosophy of Eastern aesthetics with cutting-edge scientific exploration.
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