Topic: Role of Neuroinflammation in Multiple Sclerosis

The concept of neuroinflammation in multiple sclerosis (MS) includes several components of both adaptive and innate immune responses as well as inflammatory responses of brain and spinal cord cells. The main inflammatory processes involve: infiltrating lymphocytes and myeloid cells; activated microglia, astrocytes, oligodendrocytes; alterations of blood–brain barrier integrity; cytokine/chemokine signaling. Most of these events remain compartmentalized within the CNS of MS patients possibly mediating the persistence of chronic inflammation and the accumulation of motor and cognitive disability. The current Special Issue has the purpose to examine and discuss recent insights into MS neuroinflammation cell and molecular mechanisms and the identification of potential, new MS-specific inflammatory biomarkers in order to provide a comprehensive overall view of MS neuropathology and neuroimmunology.

Multiple sclerosis, neuroinflammation, neurodegeneration, cerebrospinal fluid, intrathecal inflammation

31 Aug 2020