Special Issue

Topic: Immunotherapeutic Approaches for Treatment of Brain Tumors
A Special Issue of Neuroimmunology and Neuroinflammation
ISSN 2349-6142 (Online) 2347-8659 (Print)
Submission deadline: 31 Jul 2018
Guest Editor
Special Issue Introduction
Antigenic differences between normal and malignant cells of the cancer patient form the rationale for clinical immunotherapeutic strategies. One emerging strategy in the treatment of tumors involves stimulation of an immunologic response against the neoplastic cells. Tumor cells may evade immune responses by losing expression of antigens or major histocompatiblity complex molecules or by producing immunosuppressive cytokines. A variety of strategies have been used to increase the immunogenetic properties of vaccine therapies for brain tumors. The immune response can be augmented by genetic modification of tumor cells to secrete cytokines including IL-2, GM-CSF and interferon-γ. Alternatively, one can genetically modify the tumor cells to express co-stimulatory molecules such as B7.
Modification of neoplastic cells taken directly from tumor-bearing patients may be difficult. An alternative cell type that can be used for therapeutic immunizations is the dendritic cell (DC), which is a specialized antigen presenting cell. Pre-clinical studies have indicated that immunization with DC pulsed with tumor cell antigens can stimulate a cytotoxic T cell response that is tumor-specific and engenders protective immunity against CNS tumors. Another strategy is to transfect genomic DNA from the malignant cells into a fibroblast cell line which results in stable integration and expression of the transferred DNA. Immunization of tumor-bearing mice with the DNA-based vaccine results in the induction of cell-mediated immunity directed toward the type of tumor from which the DNA was obtained along with prolongation of survival.
The ultimate goal of cancer therapy is the elimination of every remaining tumor cell from the patient. It is unlikely that a single form of therapy is capable of achieving this goal. However, immunotherapy in combination with surgery, radiation therapy and chemotherapy will likely find a place as a new and important means of treatment for patients with brain tumors. For this Special Issue, papers are being solicited that explore the potential of different immunotherapeutic strategies for the treatment of brain tumors along with related aspects of tumor immunotherapy.
Modification of neoplastic cells taken directly from tumor-bearing patients may be difficult. An alternative cell type that can be used for therapeutic immunizations is the dendritic cell (DC), which is a specialized antigen presenting cell. Pre-clinical studies have indicated that immunization with DC pulsed with tumor cell antigens can stimulate a cytotoxic T cell response that is tumor-specific and engenders protective immunity against CNS tumors. Another strategy is to transfect genomic DNA from the malignant cells into a fibroblast cell line which results in stable integration and expression of the transferred DNA. Immunization of tumor-bearing mice with the DNA-based vaccine results in the induction of cell-mediated immunity directed toward the type of tumor from which the DNA was obtained along with prolongation of survival.
The ultimate goal of cancer therapy is the elimination of every remaining tumor cell from the patient. It is unlikely that a single form of therapy is capable of achieving this goal. However, immunotherapy in combination with surgery, radiation therapy and chemotherapy will likely find a place as a new and important means of treatment for patients with brain tumors. For this Special Issue, papers are being solicited that explore the potential of different immunotherapeutic strategies for the treatment of brain tumors along with related aspects of tumor immunotherapy.
Keywords
Immunotherapy, brain tumors, tumor vaccine, immune suppression, tumor growth, gene therapy
Submission Deadline
31 Jul 2018
Submission Information
For Author Instructions, please refer to https://www.oaepublish.com/neurosciences/author_instructions
For Online Submission, please login at https://www.oaecenter.com/login?JournalId=neurosciences
Submission Deadline: 31 Jul 2018
Contacts: Nancy Ding, Assistant Editor, editor002@nnjournal.net
Published Articles
Immunotherapeutic approaches for treatment of brain tumors
Open Access Editorial 15 Jan 2019
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Immunotherapy and checkpoint inhibitors for gliomas
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Histone deacetylase enzymes and selective histone deacetylase inhibitors for antitumor effects and enhancement of antitumor immunity in glioblastoma
Open Access Review 11 Nov 2018
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Total tumor RNA pulsed dendritic cells plus adoptive transfer of ex-vivo enriched autologous T-lymphocytes in the treatment of children with primary brain tumors
Open Access Review 28 Oct 2018
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CAR-T cell therapy in neuro-oncology: applications and toxicity
Open Access Review 17 Oct 2018
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It takes two: potential therapies and insights involving microglia and macrophages in glioblastoma
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Glioma associated microglia/macrophages, a potential pharmacological target to promote antitumor inflammatory immune response in the treatment of glioblastoma
Open Access Review 19 Sep 2018
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The novel-molecule T11TS facilitated arousal of glioma-mediated dormancy of bone-marrow hematopoietic stem-cells
Open Access Original Article 29 Aug 2018
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Systemic therapy in patients with NSCLC with brain metastasis: the emerging role of immunotherapy
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Immunotherapy for pediatric brain tumors
Open Access Review 22 Jul 2018
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Photodynamic therapy mediated immune therapy of brain tumors
Open Access Review 9 Jul 2018
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Classification of brain tumor using devernay sub-pixel edge detection and k-nearest neighbours methodology
Open Access Technical Note 18 Jun 2018
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A concise review of immunotherapy for glioblastoma
Open Access Review 14 Jun 2018
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