Special Issue

Topic: Genetics and Genomics of Cancer
A Special Issue of Journal of Translational Genetics and Genomics
ISSN 2578-5281 (Online)
Submission deadline: 30 Apr 2019
Guest Editor
Special Issue Introduction
Tumorigenesis is a multistep process that begins with the transformation of a single cell which acquires one or more of the “hallmarks of cancer”. Cells acquire these characteristics through numerous somatic mutations caused by errors of DNA replication, the action of exogenous mutagens or endogenous DNA damage, leading to the activation of oncogenes and the inactivation of tumour suppressors. Different tumours differ with respect to their mutational spectra and these patterns of mutation are often characteristic of the tumour in question. Genetic susceptibility to cancer is also conferred by inherited variants of cancer predisposition genes. As whole exome/genome sequencing becomes commonplace in a clinical genetics/personalised genomics setting, we are gradually developing an understanding of the role of both inherited and acquired variants in tumorigenesis. We plan to publish reviews of the molecular genetics of human cancers which we hope will allow the reader to compare and contrast some of the 100+ different human cancers in terms of their underlying mutational spectra.
Keywords
Cancer genetics, genomics, genome, mutation, mutational spectra, personalized medicine
Submission Deadline
30 Apr 2019
Submission Information
For Author Instructions, please refer to https://www.oaepublish.com/jtgg/author_instructions
For Online Submission, please login at https://www.oaecenter.com/login?JournalId=jtgg
Submission Deadline: 30 Apr 2019
Contacts: Lucia Liu, Assistant Editor, editor001@jtggjournal.com
Published Articles
Overview of liposarcomas and their genomic landscape
Open Access Review 21 May 2019
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Genomics of cutaneous melanoma: focus on next-generation sequencing approaches and bioinformatics
Open Access Review 1 Apr 2019
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Evolution of the prostate cancer genome towards resistance
Open Access Review 11 Mar 2019
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The somatic clinico-genomics of localized, non-indolent prostate cancer
Open Access Review 17 Dec 2018
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Genomics and genetics of clear cell renal cell carcinoma: a mini-review
Open Access Review 5 Nov 2018
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Radiogenomics of medulloblastoma: imaging surrogates of molecular biology
Open Access Review 23 Oct 2018
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Clinical and therapeutic implications of melanoma genomics
Open Access Review 27 Sep 2018
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Molecular genetics of Ewing sarcoma, model systems and finding novel (immuno-) therapeutic targets
Open Access Review 15 Jul 2018
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