Special Issue

Topic: Genetics and Genomics of Cancer

A Special Issue of Journal of Translational Genetics and Genomics

ISSN 2578-5281 (Online)

Submission deadline: 30 Apr 2019

Guest Editor(s)

David N. Cooper, PhD
Professor of Human Molecular Genetics, Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, UK.

Special Issue Introduction

Tumorigenesis is a multistep process that begins with the transformation of a single cell which acquires one or more of the “hallmarks of cancer”. Cells acquire these characteristics through numerous somatic mutations caused by errors of DNA replication, the action of exogenous mutagens or endogenous DNA damage, leading to the activation of oncogenes and the inactivation of tumour suppressors. Different tumours differ with respect to their mutational spectra and these patterns of mutation are often characteristic of the tumour in question. Genetic susceptibility to cancer is also conferred by inherited variants of cancer predisposition genes. As whole exome/genome sequencing becomes commonplace in a clinical genetics/personalised genomics setting, we are gradually developing an understanding of the role of both inherited and acquired variants in tumorigenesis. We plan to publish reviews of the molecular genetics of human cancers which we hope will allow the reader to compare and contrast some of the 100+ different human cancers in terms of their underlying mutational spectra.

Keywords

Cancer genetics, genomics, genome, mutation, mutational spectra, personalized medicine

Submission Deadline

30 Apr 2019

Submission Information

For Author Instructions, please refer to https://oaepublish.com/jtgg/author_instructions
For Online Submission, please login at https://oaemesas.com/login?JournalId=jtgg
Submission Deadline: 30 Apr 2019
Contacts: Lucia Liu, Assistant Editor, editor001@jtggjournal.com

Published Articles

Open Access Review

Overview of liposarcomas and their genomic landscape

This article belongs to the Special Issue Genetics and Genomics of Cancer
J Transl Genet Genom 2019;3:8.
DOI: 10.20517/jtgg.2019.03
Available online: 21 May 2019
Open Access Review

Genomics of cutaneous melanoma: focus on next-generation sequencing approaches and bioinformatics

This article belongs to the Special Issue Genetics and Genomics of Cancer
J Transl Genet Genom 2019;3:7.
DOI: 10.20517/jtgg.2018.33
Available online: 1 Apr 2019
Open Access Review

Evolution of the prostate cancer genome towards resistance

This article belongs to the Special Issue Genetics and Genomics of Cancer
J Transl Genet Genom 2019;3:5.
DOI: 10.20517/jtgg.2019.01
Available online: 11 Mar 2019
Open Access Review

The somatic clinico-genomics of localized, non-indolent prostate cancer

This article belongs to the Special Issue Genetics and Genomics of Cancer
J Transl Genet Genom 2018;2:21.
DOI: 10.20517/jtgg.2018.27
Available online: 17 Dec 2018
Open Access Review

Genomics and genetics of clear cell renal cell carcinoma: a mini-review

This article belongs to the Special Issue Genetics and Genomics of Cancer
J Transl Genet Genom 2018;2:17.
DOI: 10.20517/jtgg.2018.28
Available online: 5 Nov 2018
Open Access Review

Radiogenomics of medulloblastoma: imaging surrogates of molecular biology

This article belongs to the Special Issue Genetics and Genomics of Cancer
J Transl Genet Genom 2018;2:15.
DOI: 10.20517/jtgg.2018.21
Available online: 23 Oct 2018
Open Access Review

Clinical and therapeutic implications of melanoma genomics

This article belongs to the Special Issue Genetics and Genomics of Cancer
J Transl Genet Genom 2018;2:14.
DOI: 10.20517/jtgg.2018.25
Available online: 27 Sep 2018
Open Access Review

Molecular genetics of Ewing sarcoma, model systems and finding novel (immuno-) therapeutic targets

This article belongs to the Special Issue Genetics and Genomics of Cancer
J Transl Genet Genom 2018;2:10.
DOI: 10.20517/jtgg.2018.09
Available online: 15 Jul 2018
Open Access Review

Parathyroid carcinoma

This article belongs to the Special Issue Genetics and Genomics of Cancer
J Transl Genet Genom 2018;2:5.
DOI: 10.20517/jtgg.2018.08
Available online: 21 May 2018
Journal of Translational Genetics and Genomics
ISSN 2578-5281 (Online)
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All published articles are preserved here permanently:

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