Special Issue

Topic: Epidemiology and Natural History of Non-Alcoholic Liver Disease
A Special Issue of Hepatoma Research
ISSN 2454-2520 (Online) 2394-5079 (Print)
Submission deadline: 31 Aug 2020
Guest Editor(s)
Special Issue Introduction
Non-Alcoholic Liver Disease (NAFLD) is an emerging chronic liver disease correlated to insulin resistance and dysmetabolic disease worldwide. The global epidemiology is almost well-designed as far as concerning the prevalence but not for the incidence and the natural history. NAFLD/NASH (non-alcoholic steato-hepatitis) is the second indication for liver transplant in USA nowadays. We know that the liver-correlated cause of mortality of patients with NAFLD is only the third leading cause of death, the first cause is cardiovascular diseases and the second is colonic cancer in men and breast cancer in women.
The scientific community still does not have in his hands all the appropriate tools to make a correct non-invasive diagnosis to identify patients with NAFLD who can evolve in NASH or to understand who is going to progress more or less rapidly towards fibrosis/cirrhosis and/or hepatocellular carcinoma (HCC) or towards cardiovascular disease or cancer.
A lot of work must be still done both in the definition and classification of NAFLD and NASH and in identifying patients at risk to evolve towards a more aggressive form of liver disease or to die. Surveillance policy for population at risk is not yet applicable in the real practice. Finally, no effective treatments are still on the market even if more than 250 clinical trials on new drugs are ongoing worldwide.
In this Special Issue of Hepatoma Research, the real Global Epidemiology and Natural History, and new updated insights especially in the actual incidence and future trends of this new epidemic burden will be discussed by the major experts in this field.
Potential topics include, but are not limited to the following titles.
1. The global Prevalence of NAFLD and NASH
2. It is time for a New Definition of NAFLD/NASH?
3. The global Incidence of NAFLD/NASH and trend for the future
4. The "Juvenile NASH": fact or fiction?
5. The Natural History of NAFLD patients evolving to Cardiovascular Diseases (CVD)
6. The Natural History of NAFLD patients evolving to not-liver related Cancer
7. The Natural History of NAFLD patients evolving to end-stage liver diseases
8. The prevalence of Hepatocellular Carcinoma (HCC) in patients with NASH
9. The prevalence of HCC in patients with Diabetes or Obesity
10. The future trend of NAFLD/NASH: global burden epidemic or fake-news?
11. Future prospective for a better diagnosis and prognosis of NASH/NAFLD
The scientific community still does not have in his hands all the appropriate tools to make a correct non-invasive diagnosis to identify patients with NAFLD who can evolve in NASH or to understand who is going to progress more or less rapidly towards fibrosis/cirrhosis and/or hepatocellular carcinoma (HCC) or towards cardiovascular disease or cancer.
A lot of work must be still done both in the definition and classification of NAFLD and NASH and in identifying patients at risk to evolve towards a more aggressive form of liver disease or to die. Surveillance policy for population at risk is not yet applicable in the real practice. Finally, no effective treatments are still on the market even if more than 250 clinical trials on new drugs are ongoing worldwide.
In this Special Issue of Hepatoma Research, the real Global Epidemiology and Natural History, and new updated insights especially in the actual incidence and future trends of this new epidemic burden will be discussed by the major experts in this field.
Potential topics include, but are not limited to the following titles.
1. The global Prevalence of NAFLD and NASH
2. It is time for a New Definition of NAFLD/NASH?
3. The global Incidence of NAFLD/NASH and trend for the future
4. The "Juvenile NASH": fact or fiction?
5. The Natural History of NAFLD patients evolving to Cardiovascular Diseases (CVD)
6. The Natural History of NAFLD patients evolving to not-liver related Cancer
7. The Natural History of NAFLD patients evolving to end-stage liver diseases
8. The prevalence of Hepatocellular Carcinoma (HCC) in patients with NASH
9. The prevalence of HCC in patients with Diabetes or Obesity
10. The future trend of NAFLD/NASH: global burden epidemic or fake-news?
11. Future prospective for a better diagnosis and prognosis of NASH/NAFLD
Submission Deadline
31 Aug 2020
Submission Information
For Author Instructions, please refer to https://oaepublish.com/hr/author_instructions
For Online Submission, please login at https://oaemesas.com/login?JournalId=hr&SpecialIssueId=402
Submission Deadline: 31 Aug 2020
Contacts: Victoria Lee, Assistant Editor, editor_Victoria@hrjournal.net
Published Articles
Open Access Review
Role of CD4+ T-cells in the pathology of non-alcoholic fatty liver disease and related diseases
This article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver Disease
Hepatoma Res 2021;7:46.
Published on: 23 May 2021
Open Access Opinion

Mechanisms of protective effects of astaxanthin in nonalcoholic fatty liver disease
This article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver Disease
Hepatoma Res 2021;7:30.
Published on: 8 Apr 2021
Open Access Perspective
Prospects for a better diagnosis and prognosis of NAFLD: a pathologist´s view
This article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver Disease
Hepatoma Res 2021;7:27.
Published on: 8 Apr 2021
Open Access Systematic review
Systematic review of existing guidelines for NAFLD assessment
This article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver Disease
Hepatoma Res 2021;7:25.
Published on: 6 Apr 2021
Open Access Review
Clinical implications of hepatic progenitor cell activation in non-alcoholic fatty liver disease
This article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver Disease
Hepatoma Res 2021;7:15.
Published on: 2 Feb 2021
Open Access Original Article
Steatosis/steatohepatitis: how sustainable is the non-invasive instrumental differential diagnosis in clinical practice?
This article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver Disease
Hepatoma Res 2021;7:14.
Published on: 2 Feb 2021
Open Access Review

Novel high-throughput applications for NAFLD diagnostics and biomarker discovery
This article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver Disease
Hepatoma Res 2021;7:2.
Published on: 6 Jan 2021
Open Access Review
Genetic risk factors associated with NAFLD
This article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver Disease
Hepatoma Res 2020;6:85.
Published on: 4 Dec 2020
Open Access Review
Nonalcoholic fatty liver disease in lean subjects: is it all metabolic-associated fatty liver disease?
This article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver Disease
Hepatoma Res 2020;6:84.
Published on: 4 Dec 2020
Open Access Review
Sex disparity in hepatocellular carcinoma owing to NAFLD and non-NAFLD etiology: epidemiological findings and pathobiological mechanisms
This article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver Disease
Hepatoma Res 2020;6:83.
Published on: 4 Dec 2020
Open Access Review

Diabetes and NAFLD: a high-risk cohort with definite therapeutic potential
This article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver Disease
Hepatoma Res 2020;6:82.
Published on: 4 Dec 2020
Open Access Review
Prevalence and incidence of intra- and extrahepatic complications of NAFLD in patients with type 2 diabetes mellitus
This article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver Disease
Hepatoma Res 2020;6:78.
Published on: 5 Nov 2020
Open Access Original Article
The transcontinental variability of nonalcoholic fatty liver disease
This article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver Disease
Hepatoma Res 2020;6:72.
Published on: 11 Oct 2020
Open Access Commentary
From nonalcoholic fatty liver disease to metabolic dysfunction-associated fatty liver disease: is it time for a change of terminology?
This article belongs to the Special Issue Epidemiology and Natural History of Non-Alcoholic Liver Disease
Hepatoma Res 2020;6:64.
Published on: 11 Sep 2020